ID A0A091L3D6_COLST Unreviewed; 342 AA.
AC A0A091L3D6;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 08-NOV-2023, entry version 36.
DE SubName: Full=Left-right determination factor 1 {ECO:0000313|EMBL:KFP34409.1};
DE Flags: Fragment;
GN ORFNames=N325_06617 {ECO:0000313|EMBL:KFP34409.1};
OS Colius striatus (Speckled mousebird).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Coliiformes; Coliidae; Colius.
OX NCBI_TaxID=57412 {ECO:0000313|EMBL:KFP34409.1, ECO:0000313|Proteomes:UP000053615};
RN [1] {ECO:0000313|EMBL:KFP34409.1, ECO:0000313|Proteomes:UP000053615}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N325 {ECO:0000313|EMBL:KFP34409.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the TGF-beta family.
CC {ECO:0000256|ARBA:ARBA00006656}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; KK553294; KFP34409.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A091L3D6; -.
DR Proteomes; UP000053615; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR GO; GO:0005160; F:transforming growth factor beta receptor binding; IEA:InterPro.
DR CDD; cd13758; TGF_beta_LEFTY1_2; 1.
DR Gene3D; 2.60.120.970; -; 1.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR003942; LRDF.
DR InterPro; IPR001839; TGF-b_C.
DR InterPro; IPR001111; TGF-b_propeptide.
DR InterPro; IPR015615; TGF-beta-rel.
DR PANTHER; PTHR11848:SF226; LEFT-RIGHT DETERMINATION FACTOR; 1.
DR PANTHER; PTHR11848; TGF-BETA FAMILY; 1.
DR Pfam; PF00688; TGFb_propeptide; 1.
DR PIRSF; PIRSF037402; TGFb4; 1.
DR PRINTS; PR01427; TGFBETA4.
DR SMART; SM00204; TGFB; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS51362; TGF_BETA_2; 1.
PE 3: Inferred from homology;
KW Growth factor {ECO:0000256|ARBA:ARBA00023030};
KW Reference proteome {ECO:0000313|Proteomes:UP000053615};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..342
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5001876250"
FT DOMAIN 299..339
FT /note="TGF-beta family profile"
FT /evidence="ECO:0000259|PROSITE:PS51362"
FT NON_TER 342
FT /evidence="ECO:0000313|EMBL:KFP34409.1"
SQ SEQUENCE 342 AA; 39325 MW; 94D54CA1F8E6CC01 CRC64;
MDARVTRMLY VLCLIITVQA FTQEGFKEVL LKQLGLSEVP TFHKRDLVDL VIPDHVTNRY
ISMLKRHRVK RRALPSLAGI LRGTPGNAAE AFYSDSTTRQ HLIFDMEGRI PKNSEVTMAE
LKLFKKPLDR ANLPVKQPHR PVSNARVSVY WVQRHHDGTN RTSLIDSRLV PIRESGWRNF
DVTQAVHYWL RNKRREPMFL EVWIEGERAG SHASEMAKAV HFTSQDPKDK ALGKPELVLY
TLDLEDYGGP GDCPEEAVAG KFTCCRQKHY ISFRELSWAQ HWIIERPPTR RRRFGYGERA
CAVAETSPLP MIYLVKRGNR TEIQVAEFPN MVVEKCSCVT NG
//
