ID   A0A091L5C4_CATAU        Unreviewed;       974 AA.
AC   A0A091L5C4;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   27-MAR-2024, entry version 33.
DE   RecName: Full=Alpha-mannosidase {ECO:0000256|RuleBase:RU361199};
DE            EC=3.2.1.- {ECO:0000256|RuleBase:RU361199};
DE   Flags: Fragment;
GN   ORFNames=N323_11259 {ECO:0000313|EMBL:KFP50448.1};
OS   Cathartes aura (Turkey vulture) (Vultur aura).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Accipitriformes; Cathartidae; Cathartes.
OX   NCBI_TaxID=43455 {ECO:0000313|EMBL:KFP50448.1, ECO:0000313|Proteomes:UP000053745};
RN   [1] {ECO:0000313|EMBL:KFP50448.1, ECO:0000313|Proteomes:UP000053745}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BGI_N323 {ECO:0000313|EMBL:KFP50448.1};
RA   Zhang G., Li C.;
RT   "Genome evolution of avian class.";
RL   Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|RuleBase:RU361199};
CC       Note=Binds 1 zinc ion per subunit. {ECO:0000256|RuleBase:RU361199};
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 38 family.
CC       {ECO:0000256|ARBA:ARBA00009792, ECO:0000256|RuleBase:RU361199}.
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DR   EMBL; KL296313; KFP50448.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A091L5C4; -.
DR   Proteomes; UP000053745; Unassembled WGS sequence.
DR   GO; GO:0004559; F:alpha-mannosidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0030246; F:carbohydrate binding; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006013; P:mannose metabolic process; IEA:InterPro.
DR   Gene3D; 2.60.40.1360; -; 1.
DR   Gene3D; 3.20.110.10; Glycoside hydrolase 38, N terminal domain; 1.
DR   Gene3D; 1.20.1270.50; Glycoside hydrolase family 38, central domain; 1.
DR   Gene3D; 2.60.40.1180; Golgi alpha-mannosidase II; 1.
DR   InterPro; IPR011013; Gal_mutarotase_sf_dom.
DR   InterPro; IPR011330; Glyco_hydro/deAcase_b/a-brl.
DR   InterPro; IPR011682; Glyco_hydro_38_C.
DR   InterPro; IPR015341; Glyco_hydro_38_cen.
DR   InterPro; IPR037094; Glyco_hydro_38_cen_sf.
DR   InterPro; IPR000602; Glyco_hydro_38_N.
DR   InterPro; IPR027291; Glyco_hydro_38_N_sf.
DR   InterPro; IPR028995; Glyco_hydro_57/38_cen_sf.
DR   InterPro; IPR013780; Glyco_hydro_b.
DR   PANTHER; PTHR11607; ALPHA-MANNOSIDASE; 1.
DR   PANTHER; PTHR11607:SF28; EPIDIDYMIS-SPECIFIC ALPHA-MANNOSIDASE; 1.
DR   Pfam; PF09261; Alpha-mann_mid; 1.
DR   Pfam; PF07748; Glyco_hydro_38C; 1.
DR   Pfam; PF01074; Glyco_hydro_38N; 1.
DR   SMART; SM00872; Alpha-mann_mid; 1.
DR   SUPFAM; SSF88688; Families 57/38 glycoside transferase middle domain; 1.
DR   SUPFAM; SSF74650; Galactose mutarotase-like; 1.
DR   SUPFAM; SSF88713; Glycoside hydrolase/deacetylase; 1.
PE   3: Inferred from homology;
KW   Glycosidase {ECO:0000256|ARBA:ARBA00023295, ECO:0000256|RuleBase:RU361199};
KW   Hydrolase {ECO:0000256|RuleBase:RU361199};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW   ECO:0000256|RuleBase:RU361199};
KW   Reference proteome {ECO:0000313|Proteomes:UP000053745};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|RuleBase:RU361199}.
FT   DOMAIN          316..399
FT                   /note="Glycoside hydrolase family 38 central"
FT                   /evidence="ECO:0000259|SMART:SM00872"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:KFP50448.1"
FT   NON_TER         974
FT                   /evidence="ECO:0000313|EMBL:KFP50448.1"
SQ   SEQUENCE   974 AA;  111183 MW;  3EA1A7CD7D7470E4 CRC64;
     YVFFLQESMH AYAANVYTSV VEELMKGKQR KFIAVEQEFF RLWWDAVATD THKQQVHQLL
     QEGRLEFVIG GQVMHDEAVT LIDDQILQLT EGHGFLYETF GIRPRFSWHV DPFGASAATP
     TLFALAGFNA HLISRIDYDL KADMQKNKKL QFVWQGSPSL SERQEIFTHV MDQYSYCTPS
     QIPFSNRSGF YWNGIAAFPD PPKDGVYPNM SLPVTDTNIH LYAQTMVANI KERAAWFRTS
     DVLWPWGCDK QFFNASVQYS NMDLLLDYIN KHSDEFGVAV QYATVGDYFQ AVYSKNLIWE
     IRDSQDFLPY STEPFQAWTG FYTSRSTLKG IARRASSLLY AGESFFTQYV QKHPASSICK
     CGALRQLQSL RWAVSEVQHH DGITGTESPK VKDMYMNNLM YGMFNVKKLM ACIIFDMNSA
     KKNGEVYSSV YNKDSGIPDV DQYVVVYNPL AWNITTVVTV SVSHLAVSVY DELGHSVPAQ
     VQSSAESHST YDLYILVAIS GLSYRKYNVK PLNGKESAFI GRSVKYKRKG ITHVDQQSRQ
     FLPVVNNCYQ VLFDQSTNLM HSITERETNQ TVQLTQEFLE YRVNGDVTKG PISDNYLFAP
     NASAVPVSKA VGLEVVSGNL MTEIRQYFYS NVTARDYIYA VYTRMYTVPE GYDGKLLCHR
     IEQEYSVGPL ELNREAVLRT STNLNTRQLL YTDSNGYQIQ KRPFKAYVNN TVARNYYPMV
     QTAYIEDNTT RLMLLAERAH GVSSQGNGQV EVMLHRRLWN NLQWDLNYNL TLNDSSVVRP
     VIWLILGTKA VTNILYRTSG LALEHRPVVM FGALSGDKPK LPGQLQQNSV HGSPVTVPPN
     LHLQTLSIPG WRYSSNHAEQ VHSVRMGKQK QGDADFSRVL LRIRHLYEVG EDPVLSQPVM
     VNLKSLLKEL GSVMLVEERS LTGTWDVNTL KRWKWKTAQY PSKGFFNSTE TSENCIVTVH
     PREIRTFFVY FQGQ
//