ID   A0A091LN37_CARIC        Unreviewed;       553 AA.
AC   A0A091LN37;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   24-JAN-2024, entry version 24.
DE   SubName: Full=Mucolipin-3 {ECO:0000313|EMBL:KFP60903.1};
DE   Flags: Fragment;
GN   ORFNames=N322_09496 {ECO:0000313|EMBL:KFP60903.1};
OS   Cariama cristata (Red-legged seriema).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Cariamiformes; Cariamidae; Cariama.
OX   NCBI_TaxID=54380 {ECO:0000313|EMBL:KFP60903.1, ECO:0000313|Proteomes:UP000054116};
RN   [1] {ECO:0000313|EMBL:KFP60903.1, ECO:0000313|Proteomes:UP000054116}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BGI_N322 {ECO:0000313|EMBL:KFP60903.1};
RA   Zhang G., Li C.;
RT   "Genome evolution of avian class.";
RL   Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Endosome membrane
CC       {ECO:0000256|ARBA:ARBA00004337}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004337}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
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DR   EMBL; KK504607; KFP60903.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A091LN37; -.
DR   Proteomes; UP000054116; Unassembled WGS sequence.
DR   GO; GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005261; F:monoatomic cation channel activity; IEA:InterPro.
DR   CDD; cd21072; ELD_TRPML3; 1.
DR   Gene3D; 1.10.287.70; -; 1.
DR   InterPro; IPR049134; MCLN_ECD.
DR   InterPro; IPR047317; MCOLN3_ELD.
DR   InterPro; IPR039031; Mucolipin.
DR   InterPro; IPR013122; PKD1_2_channel.
DR   PANTHER; PTHR12127; MUCOLIPIN; 1.
DR   PANTHER; PTHR12127:SF5; MUCOLIPIN-3; 1.
DR   Pfam; PF21381; MCLN_ECD; 1.
DR   Pfam; PF08016; PKD_channel; 1.
PE   4: Predicted;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Endosome {ECO:0000256|ARBA:ARBA00022753};
KW   Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW   Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000054116};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT   TRANSMEM        287..308
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        340..358
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        370..392
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        412..434
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        480..501
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          87..270
FT                   /note="Mucolipin extracytosolic"
FT                   /evidence="ECO:0000259|Pfam:PF21381"
FT   DOMAIN          372..508
FT                   /note="Polycystin cation channel PKD1/PKD2"
FT                   /evidence="ECO:0000259|Pfam:PF08016"
FT   REGION          1..26
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         553
FT                   /evidence="ECO:0000313|EMBL:KFP60903.1"
SQ   SEQUENCE   553 AA;  63919 MW;  E6CE19A366C0BFC9 CRC64;
     MENPEVAVSS CSAHDDENLC SPKRQPSVSQ EGLLEDQLRR KLKFFFMNPC EKFWARGRKP
     WKLGIQLLKI AMVTVQLVVF GLSNQMVVAF KEENTVAFKH LFLKGYMDRM DDTYAVYTQT
     DVYDQIFFAI NQYLQLPNIS VGNHAYEKRG AEETALAVCQ QFYKQGTICP GNDTFDIDPE
     IVTDCLYIEP MTPLDHTTVG KHNLNFTLDF HRLVTVQLMF NLKAINLQTV RHHELPDCYD
     FTLRIVFDNK AHSGRIKISL DNDIAIRECR DWHVSGSIQK NTHYMMIFDA FVILTCLASL
     ILCTRSVVKG IRLQREFVSF FLYYYKKEVS FSDQMEFVNG WYILIVVSDV LTIVGSTLKM
     EIQAKSLTSY DVCSILLGTS TLLVWLGVIR YLGFFQKYNI LILTLRAALP NVMRFCCCAA
     MIYLGYCFCG WIVLGPYHVK FRSLNMVSEC LFSLINGDDM FATFAKMQQK SYLVWLFSRI
     YLYSFISLFT YMVLSLFIAL ITDTYETVKH YQQDGFPETE LQRFISQCKD LPNSGRYRLE
     EESSASLFCC CNG
//