ID A0A091LR14_9GRUI Unreviewed; 804 AA.
AC A0A091LR14;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE RecName: Full=Toll-like receptor 4 {ECO:0000256|ARBA:ARBA00040109};
DE Flags: Fragment;
GN ORFNames=N324_04944 {ECO:0000313|EMBL:KFP45211.1};
OS Chlamydotis macqueenii (Macqueen's bustard).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Gruiformes; Otididae; Chlamydotis.
OX NCBI_TaxID=187382 {ECO:0000313|EMBL:KFP45211.1, ECO:0000313|Proteomes:UP000053330};
RN [1] {ECO:0000313|EMBL:KFP45211.1, ECO:0000313|Proteomes:UP000053330}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N324 {ECO:0000313|EMBL:KFP45211.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell projection, ruffle
CC {ECO:0000256|ARBA:ARBA00004466}. Early endosome
CC {ECO:0000256|ARBA:ARBA00004412}. Endosome
CC {ECO:0000256|ARBA:ARBA00004177}. Membrane
CC {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the Toll-like receptor family.
CC {ECO:0000256|ARBA:ARBA00009634}.
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DR EMBL; KK761998; KFP45211.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A091LR14; -.
DR Proteomes; UP000053330; Unassembled WGS sequence.
DR GO; GO:0005769; C:early endosome; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0001726; C:ruffle; IEA:UniProtKB-SubCell.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR GO; GO:0002224; P:toll-like receptor signaling pathway; IEA:InterPro.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR017241; Toll-like_receptor.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR PANTHER; PTHR24365; TOLL-LIKE RECEPTOR; 1.
DR PANTHER; PTHR24365:SF521; TOLL-LIKE RECEPTOR 4; 1.
DR Pfam; PF00560; LRR_1; 1.
DR Pfam; PF13855; LRR_8; 2.
DR Pfam; PF01582; TIR; 1.
DR PIRSF; PIRSF037595; Toll-like_receptor; 5.
DR PRINTS; PR01537; INTRLKN1R1F.
DR SMART; SM00369; LRR_TYP; 8.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF52058; L domain-like; 2.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR PROSITE; PS50104; TIR; 1.
PE 3: Inferred from homology;
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Endosome {ECO:0000256|ARBA:ARBA00022753};
KW Immunity {ECO:0000256|ARBA:ARBA00022859};
KW Inflammatory response {ECO:0000256|ARBA:ARBA00023198};
KW Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000313|EMBL:KFP45211.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000053330};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 615..633
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 657..800
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFP45211.1"
FT NON_TER 804
FT /evidence="ECO:0000313|EMBL:KFP45211.1"
SQ SEQUENCE 804 AA; 91640 MW; 47146F511952E7EE CRC64;
DLLLLQVVPS KAFRCMGLNI SGVPAEVPNT TQNLDLSFSN LKSLESNYFS SVPELQLLDL
TRCHLHTIED NSFKDLNKLS TLILTANPLQ YLGTAAFYGL TSLKKLVLVE TNIASLTDLP
IGHLHTLQEL NLGHNNIASL KLPKYFTNLT SLRHLSFLFN KITYISKGDL DALREVNRLN
LTLVLSLNDI KFIEPGSFAK IHLGELVLRS SFENFNVMHA SLQGLTGLEV NRLIVGEFSD
RQRLVDFQSG LLSGLCQVHM QEFVLISFRE FENDTDTLFN CIGNVSSIRL VDLRLEEVSK
VPMFSQVKQL ECKKCKFKEM PAEKLSLFKE LRVLRIIKSK HLNSFRQKFK SLRNLEVADF
SENRLSFTGC CSRHFHECPN LKHLNLSFNS DISITGDFTN VKNLLYLDLQ HTKLFGPGSY
PVFLSLQKLI YLDISYTRTH VKSQCTFCGL NSLKVLKMAG NSFENNKLSN NFKNLSHLHT
LDISNCKLVQ VDQSTFDALS ELKELNISNN KLLSFDPVVY KPLQALTALD FSNNQLSVLL
DSALEILPDS LVLLDISQNL FECSCVHFNF LKWITDKQKL LQNKKLMICH TPAYLKNTSL
PVFALSSCRL KGSTVAFSVI MFLAVAVFLF LIYKYYFQLY YSLVLLSGCK HSAERGDTYD
AFVIHSSKDQ EWVMKELVEP LEGGTPPFQF CLYYRDFLPG VPIVTNIIQE GFLSSRNVIA
VISTDFLESK WCSFEFDIAQ SWQLVEGKAG IIMIVLEEVN KALLRQRLGL SRYLRRNTYL
EWKNKEISKH IFWRQLTGIL LEGK
//
