ID   A0A091M769_CATAU        Unreviewed;       543 AA.
AC   A0A091M769;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   24-JAN-2024, entry version 27.
DE   SubName: Full=2-hydroxyacyl-CoA lyase 1 {ECO:0000313|EMBL:KFP54366.1};
DE   Flags: Fragment;
GN   ORFNames=N323_05083 {ECO:0000313|EMBL:KFP54366.1};
OS   Cathartes aura (Turkey vulture) (Vultur aura).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Accipitriformes; Cathartidae; Cathartes.
OX   NCBI_TaxID=43455 {ECO:0000313|EMBL:KFP54366.1, ECO:0000313|Proteomes:UP000053745};
RN   [1] {ECO:0000313|EMBL:KFP54366.1, ECO:0000313|Proteomes:UP000053745}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BGI_N323 {ECO:0000313|EMBL:KFP54366.1};
RA   Zhang G., Li C.;
RT   "Genome evolution of avian class.";
RL   Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=2-hydroxyoctadecanoyl-CoA = formyl-CoA + heptadecanal;
CC         Xref=Rhea:RHEA:55196, ChEBI:CHEBI:57376, ChEBI:CHEBI:74116,
CC         ChEBI:CHEBI:138631; Evidence={ECO:0000256|ARBA:ARBA00000194};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:55197;
CC         Evidence={ECO:0000256|ARBA:ARBA00000194};
CC   -!- COFACTOR:
CC       Name=thiamine diphosphate; Xref=ChEBI:CHEBI:58937;
CC         Evidence={ECO:0000256|ARBA:ARBA00001964};
CC   -!- SIMILARITY: Belongs to the TPP enzyme family.
CC       {ECO:0000256|ARBA:ARBA00007812, ECO:0000256|RuleBase:RU362132}.
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DR   EMBL; KL318094; KFP54366.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A091M769; -.
DR   Proteomes; UP000053745; Unassembled WGS sequence.
DR   GO; GO:0016829; F:lyase activity; IEA:UniProtKB-KW.
DR   GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
DR   GO; GO:0030976; F:thiamine pyrophosphate binding; IEA:InterPro.
DR   CDD; cd02004; TPP_BZL_OCoD_HPCL; 1.
DR   CDD; cd07035; TPP_PYR_POX_like; 1.
DR   Gene3D; 3.40.50.970; -; 2.
DR   Gene3D; 3.40.50.1220; TPP-binding domain; 1.
DR   InterPro; IPR029035; DHS-like_NAD/FAD-binding_dom.
DR   InterPro; IPR045025; HACL1-like.
DR   InterPro; IPR029061; THDP-binding.
DR   InterPro; IPR012000; Thiamin_PyroP_enz_cen_dom.
DR   InterPro; IPR012001; Thiamin_PyroP_enz_TPP-bd_dom.
DR   InterPro; IPR011766; TPP_enzyme_TPP-bd.
DR   PANTHER; PTHR43710; 2-HYDROXYACYL-COA LYASE; 1.
DR   PANTHER; PTHR43710:SF2; 2-HYDROXYACYL-COA LYASE 1; 1.
DR   Pfam; PF02775; TPP_enzyme_C; 1.
DR   Pfam; PF00205; TPP_enzyme_M; 1.
DR   Pfam; PF02776; TPP_enzyme_N; 1.
DR   SUPFAM; SSF52467; DHS-like NAD/FAD-binding domain; 1.
DR   SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 2.
PE   3: Inferred from homology;
KW   Lyase {ECO:0000313|EMBL:KFP54366.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000053745};
KW   Thiamine pyrophosphate {ECO:0000256|RuleBase:RU362132}.
FT   DOMAIN          1..101
FT                   /note="Thiamine pyrophosphate enzyme N-terminal TPP-
FT                   binding"
FT                   /evidence="ECO:0000259|Pfam:PF02776"
FT   DOMAIN          168..297
FT                   /note="Thiamine pyrophosphate enzyme central"
FT                   /evidence="ECO:0000259|Pfam:PF00205"
FT   DOMAIN          366..522
FT                   /note="Thiamine pyrophosphate enzyme TPP-binding"
FT                   /evidence="ECO:0000259|Pfam:PF02775"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:KFP54366.1"
FT   NON_TER         543
FT                   /evidence="ECO:0000313|EMBL:KFP54366.1"
SQ   SEQUENCE   543 AA;  59365 MW;  F658E24DC40254AA CRC64;
     NIEYMFGIVG IPVTEIAIAA QAVGIKYVGM RNEQAACYAA SAVGYLTGRP GVCLVVSGPG
     FLHALGGMAN ATMNCWPLIV IGGSSDRNQE TMGAFQEFPQ VEAGRLYNKL SVRPSSLEAV
     RTSIYGRPGS CYIDIPGDFV NLQVNKSSVK HVECCLPPAI STAEHSAVSK AASIIARSKQ
     PLLIIGKGAA YSHAENNIRK LVDLCGLPFL PTPMAKGVVP DNHPNCVAAA RSTALQDADV
     IILLGARLNW ILHFGLPPRF RQDVKVIQID ICAEELGNNV RPAAILLGDI NAVTKQLLEE
     FSKRPLKYPS NSEWWKKLRE KIMTNEERSK GLALQKSLPM NYYTVFHHIR EQIPKDCILV
     SEGANTMDIG RTMLPNYYPR QRLDAGTFGT MGVGLGFAIA AAMVAKDRTP EKQVICIEGD
     SAFGFSGMEV ETICRYNLPI LIIIVNNNGI YTGLDADTWK EMLKFGDPAT CVPPVSLLPN
     SHYEEIMSAF GGKGYFVKTP EELQSALKAS MTDKQTPALI NVMIDPQSER KKQEFPWLTR
     SNL
//