ID A0A091MDU2_CARIC Unreviewed; 648 AA.
AC A0A091MDU2;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 24-JAN-2024, entry version 25.
DE RecName: Full=Macoilin {ECO:0000256|ARBA:ARBA00021882};
DE AltName: Full=Transmembrane protein 57 {ECO:0000256|ARBA:ARBA00031129};
DE Flags: Fragment;
GN ORFNames=N322_08749 {ECO:0000313|EMBL:KFP68942.1};
OS Cariama cristata (Red-legged seriema).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Cariamiformes; Cariamidae; Cariama.
OX NCBI_TaxID=54380 {ECO:0000313|EMBL:KFP68942.1, ECO:0000313|Proteomes:UP000054116};
RN [1] {ECO:0000313|EMBL:KFP68942.1, ECO:0000313|Proteomes:UP000054116}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N322 {ECO:0000313|EMBL:KFP68942.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Plays a role in the regulation of neuronal activity.
CC {ECO:0000256|ARBA:ARBA00003440}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004477}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004477}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}. Nucleus membrane
CC {ECO:0000256|ARBA:ARBA00004232}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004232}. Rough endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004269}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004269}.
CC -!- SIMILARITY: Belongs to the macoilin family.
CC {ECO:0000256|ARBA:ARBA00008298}.
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DR EMBL; KK528351; KFP68942.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A091MDU2; -.
DR Proteomes; UP000054116; Unassembled WGS sequence.
DR GO; GO:0031965; C:nuclear membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0030867; C:rough endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0023041; P:neuronal signal transduction; IEA:InterPro.
DR InterPro; IPR019130; Macoilin.
DR PANTHER; PTHR47464; MACOILIN; 1.
DR PANTHER; PTHR47464:SF2; MACOILIN; 1.
DR Pfam; PF09726; Macoilin; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000054116};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 47..69
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 90..108
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 128..148
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 307..359
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 367..535
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 577..604
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 307..335
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFP68942.1"
FT NON_TER 648
FT /evidence="ECO:0000313|EMBL:KFP68942.1"
SQ SEQUENCE 648 AA; 74331 MW; 04D3D6DFF921620C CRC64;
STFLYLKFLV VWALVLLADF VLEFRFEYLW PFWLFIRSVY DSFRYQGLAF SVFFVCVAFT
SNIICLLFIP IQWLFFAAST YVWVQYVWHT ERGVCLPTVS LWILFVYIEA AIRFKDLKNF
HVDLCRPFAA HCIGYPVVTL GFGFKSYVSY KMRLRKQKEV QKENEFYMQL LQQALPPEQQ
MLQRQEREAE EGNGFFFYFG IAAAKGLSDM DSSILLQHNG GIPANKKLSA TLPELEYREK
GKEKDKDAKK HNLGINNNIL QPVDSKIQEI EYMENHINSK RLNNDLVGST ENLLKEDSCT
ASSKNYKNVS GVVNSSPRSH SATNGSIPSS STKNEKKQKC ASKSPSTHKD LMENCIPNNQ
LSKPDALVRL EQDIKKLKAD LQASRQIEQE LRSQISSLTN TERGIRSEIG QLRQENELLQ
NKLHNAVQMK QKDKQMISQL EKKLKAEQEA RAFVEKQLME EKKRKKLEEA TAARAVAFAA
ATRGECTETL RNRIRELETE CKKLTIDIKL KEDQIRELEM KVQELRKYKE NEKDTEVLMS
ALSAMQDKTQ HLENSLSAET RIKLDLFSAL GDAKRQLEIA QGQIIQKDQE IKDLKQKIAE
VMAVMPSITY TAATSTLSPV SPHYSSKFVE TSPSGLDPNA SVYQPLKK
//
