ID A0A091MF92_9PASS Unreviewed; 895 AA.
AC A0A091MF92;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 03-MAY-2023, entry version 34.
DE RecName: Full=hexokinase {ECO:0000256|ARBA:ARBA00012324};
DE EC=2.7.1.1 {ECO:0000256|ARBA:ARBA00012324};
DE Flags: Fragment;
GN ORFNames=N310_00833 {ECO:0000313|EMBL:KFP71643.1};
OS Acanthisitta chloris (rifleman).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Passeriformes; Acanthisittidae;
OC Acanthisitta.
OX NCBI_TaxID=57068 {ECO:0000313|EMBL:KFP71643.1, ECO:0000313|Proteomes:UP000053537};
RN [1] {ECO:0000313|EMBL:KFP71643.1, ECO:0000313|Proteomes:UP000053537}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N310 {ECO:0000313|EMBL:KFP71643.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + D-glucose = ADP + D-glucose 6-phosphate + H(+);
CC Xref=Rhea:RHEA:17825, ChEBI:CHEBI:4167, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:61548, ChEBI:CHEBI:456216; EC=2.7.1.1;
CC Evidence={ECO:0000256|ARBA:ARBA00000435};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:17826;
CC Evidence={ECO:0000256|ARBA:ARBA00000435};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + D-hexose = ADP + D-hexose 6-phosphate + H(+);
CC Xref=Rhea:RHEA:22740, ChEBI:CHEBI:4194, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:61567, ChEBI:CHEBI:456216; EC=2.7.1.1;
CC Evidence={ECO:0000256|ARBA:ARBA00000417};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:22741;
CC Evidence={ECO:0000256|ARBA:ARBA00000417};
CC -!- PATHWAY: Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-
CC phosphate and glycerone phosphate from D-glucose: step 1/4.
CC {ECO:0000256|ARBA:ARBA00004888}.
CC -!- PATHWAY: Carbohydrate metabolism; hexose metabolism.
CC {ECO:0000256|ARBA:ARBA00005028}.
CC -!- SIMILARITY: Belongs to the hexokinase family.
CC {ECO:0000256|ARBA:ARBA00009225}.
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DR EMBL; KK823721; KFP71643.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A091MF92; -.
DR UniPathway; UPA00109; UER00180.
DR UniPathway; UPA00242; -.
DR Proteomes; UP000053537; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0005536; F:glucose binding; IEA:InterPro.
DR GO; GO:0004396; F:hexokinase activity; IEA:UniProtKB-EC.
DR GO; GO:0006096; P:glycolytic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0019318; P:hexose metabolic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0001678; P:intracellular glucose homeostasis; IEA:InterPro.
DR CDD; cd00012; NBD_sugar-kinase_HSP70_actin; 2.
DR Gene3D; 3.30.420.40; -; 2.
DR Gene3D; 3.40.367.20; -; 2.
DR InterPro; IPR043129; ATPase_NBD.
DR InterPro; IPR001312; Hexokinase.
DR InterPro; IPR019807; Hexokinase_BS.
DR InterPro; IPR022673; Hexokinase_C.
DR InterPro; IPR022672; Hexokinase_N.
DR PANTHER; PTHR19443; HEXOKINASE; 1.
DR PANTHER; PTHR19443:SF28; HEXOKINASE HKDC1; 1.
DR Pfam; PF00349; Hexokinase_1; 2.
DR Pfam; PF03727; Hexokinase_2; 2.
DR PRINTS; PR00475; HEXOKINASE.
DR SUPFAM; SSF53067; Actin-like ATPase domain; 4.
DR PROSITE; PS00378; HEXOKINASE_1; 1.
DR PROSITE; PS51748; HEXOKINASE_2; 2.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Glycolysis {ECO:0000256|ARBA:ARBA00023152};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:KFP71643.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000053537};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 2..198
FT /note="Hexokinase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00349"
FT DOMAIN 205..438
FT /note="Hexokinase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03727"
FT DOMAIN 449..646
FT /note="Hexokinase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00349"
FT DOMAIN 652..886
FT /note="Hexokinase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03727"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFP71643.1"
FT NON_TER 895
FT /evidence="ECO:0000313|EMBL:KFP71643.1"
SQ SEQUENCE 895 AA; 99364 MW; 9DF8077B689263C5 CRC64;
QVDRYLYHLR LSDDVLLDVL ARFQAEMVKG LGRDTNPTAA VKMLPSFVRS LPDGSEKGDF
LAVDLGGSQF RAHQVKVFDD GKQSSQLESK FYPTPKEVTQ GNGAELFDYV ADCLLDFMAT
KNLKHKKLPL GFTFSFPCKQ TKLEEGVLLA WTKHFKVRGV QDTDVVSSLH KALQKHKANV
EVLALVNDTV GTMMTCGYDD PRCEVGLIIG TGTNACYMEE MRHIELVEGD EGRMCINTEW
GAFGDDGALD DLRTEFDREL DLGSLNPGKQ LFEKMISSLY LGELVRLILL KMAKEGLLFN
GKVSTALLTK GKIEMKHVSA MEKYKEGLSN AKEILTELSL FPSEEDCIAV QHVCTIVSFR
SANLCAAALA AILTRLRENK KLLRMRTTVG IDGGLYKTHP QYAKRLHKVV RRLVPNCDVR
FLLSVSGSGK GAAMVTAVAH RLVTQRKQID ATLAPFLLSL KTLREVKDKM RTELEYGLKR
ETQANATVKM LPTYVCGTPD GTEKGKFLAL DLGGTNFRVL LVKIRSGRRR SVQMYNKIFA
IPLEIMQGTG EELFDHIVQC IANFLDYMGI KGARLPLGFT FSFPCRQASI DKGTLVGWTK
GFKATGCEGE DVVDMLREAI RRRNEFDLDI VAVVNDTVGT MMTCGYEDPN CEIGLIAGTG
SNVCYMEDMK NIEIVEGNEG KMCINTEWGA FGDNGCIDNI RTKYDKEVDE GSLNPGKQRY
EKMTSGMYLG EIVRQILIDL TKQGLLFRGH ISESLRKRGI FETKFLSQIE SDRLALLQVR
QILRQLGLDS KCDDSIIVKE VCGVVSRRAA QLCGAGLAAV VEKKRENQGV EHLQITVGVD
GTLYKLHPHF SRILQETVKQ LAPQCDVTFM LSEDGSGKGA ALITAVAKRL HSVGQ
//
