ID A0A091MJ54_9PASS Unreviewed; 289 AA.
AC A0A091MJ54;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 03-MAY-2023, entry version 27.
DE RecName: Full=Sesquipedalian {ECO:0000256|RuleBase:RU369082};
DE Short=Ses {ECO:0000256|RuleBase:RU369082};
DE AltName: Full=PH domain-containing endocytic trafficking adaptor {ECO:0000256|RuleBase:RU369082};
DE Flags: Fragment;
GN ORFNames=N310_00526 {ECO:0000313|EMBL:KFP73737.1};
OS Acanthisitta chloris (rifleman).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Passeriformes; Acanthisittidae;
OC Acanthisitta.
OX NCBI_TaxID=57068 {ECO:0000313|EMBL:KFP73737.1, ECO:0000313|Proteomes:UP000053537};
RN [1] {ECO:0000313|EMBL:KFP73737.1, ECO:0000313|Proteomes:UP000053537}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N310 {ECO:0000313|EMBL:KFP73737.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Plays a role in endocytic trafficking. Required for receptor
CC recycling from endosomes, both to the trans-Golgi network and the
CC plasma membrane. {ECO:0000256|RuleBase:RU369082}.
CC -!- SUBCELLULAR LOCATION: Early endosome {ECO:0000256|RuleBase:RU369082}.
CC Recycling endosome {ECO:0000256|RuleBase:RU369082}. Golgi apparatus,
CC trans-Golgi network {ECO:0000256|RuleBase:RU369082}. Cytoplasmic
CC vesicle, clathrin-coated vesicle {ECO:0000256|RuleBase:RU369082}.
CC -!- SIMILARITY: Belongs to the sesquipedalian family.
CC {ECO:0000256|RuleBase:RU369082}.
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DR EMBL; KK827301; KFP73737.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A091MJ54; -.
DR Proteomes; UP000053537; Unassembled WGS sequence.
DR GO; GO:0030136; C:clathrin-coated vesicle; IEA:UniProtKB-SubCell.
DR GO; GO:0005829; C:cytosol; IEA:GOC.
DR GO; GO:0005769; C:early endosome; IEA:UniProtKB-SubCell.
DR GO; GO:0055037; C:recycling endosome; IEA:UniProtKB-SubCell.
DR GO; GO:0005802; C:trans-Golgi network; IEA:UniProtKB-UniRule.
DR GO; GO:0007032; P:endosome organization; IEA:UniProtKB-UniRule.
DR GO; GO:0001881; P:receptor recycling; IEA:UniProtKB-UniRule.
DR GO; GO:0042147; P:retrograde transport, endosome to Golgi; IEA:UniProtKB-UniRule.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR045188; Boi1/Boi2-like.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR22902:SF51; PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY A MEMBER 3; 1.
DR PANTHER; PTHR22902; SESQUIPEDALIAN; 1.
DR Pfam; PF00169; PH; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 3: Inferred from homology;
KW Cytoplasmic vesicle {ECO:0000256|RuleBase:RU369082};
KW Endosome {ECO:0000256|RuleBase:RU369082};
KW Golgi apparatus {ECO:0000256|RuleBase:RU369082};
KW Phosphoprotein {ECO:0000256|RuleBase:RU369082};
KW Reference proteome {ECO:0000313|Proteomes:UP000053537}.
FT DOMAIN 1..82
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 187..289
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 221..235
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 236..269
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFP73737.1"
FT NON_TER 289
FT /evidence="ECO:0000313|EMBL:KFP73737.1"
SQ SEQUENCE 289 AA; 32554 MW; 53F17734E9378589 CRC64;
LLGWQPRWFV LDNGILSYYD SQDDVCKGSK GSIKMAVCEI KVHATDNTRM ELIIPGEQHF
YMKAVNAAER QRWLVALGSA KACLADTRTK KEKEISETSE SLKTKMSELR LYCDLLMQQV
HTIQEFVHHD ETRSPPSIEN MNEASSLLSA TCNTFISTLE ECVKIANAKF KPEMFQLPQP
DPLVSPVSPS PVQMMKRSIS HPGPCYSERI NHPVKEPGSS LHRFSQRRRR TYSDTESYSD
TPSEDSQKSA HCSRSAVNGD VVSSTIPEEN KSLSKERSDL EETLSSFSS
//
