ID A0A091MV46_CARIC Unreviewed; 453 AA.
AC A0A091MV46;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 08-NOV-2023, entry version 39.
DE SubName: Full=Bone morphogenetic protein 5 {ECO:0000313|EMBL:KFP65355.1};
GN ORFNames=N322_11443 {ECO:0000313|EMBL:KFP65355.1};
OS Cariama cristata (Red-legged seriema).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Cariamiformes; Cariamidae; Cariama.
OX NCBI_TaxID=54380 {ECO:0000313|EMBL:KFP65355.1, ECO:0000313|Proteomes:UP000054116};
RN [1] {ECO:0000313|EMBL:KFP65355.1, ECO:0000313|Proteomes:UP000054116}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N322 {ECO:0000313|EMBL:KFP65355.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the TGF-beta family.
CC {ECO:0000256|ARBA:ARBA00006656, ECO:0000256|RuleBase:RU000354}.
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DR EMBL; KK517815; KFP65355.1; -; Genomic_DNA.
DR RefSeq; XP_009699116.1; XM_009700814.1.
DR AlphaFoldDB; A0A091MV46; -.
DR GeneID; 104162151; -.
DR KEGG; ccri:104162151; -.
DR CTD; 653; -.
DR OrthoDB; 2912454at2759; -.
DR Proteomes; UP000054116; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR CDD; cd19395; TGF_beta_BMP5; 1.
DR Gene3D; 2.60.120.970; -; 1.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR001839; TGF-b_C.
DR InterPro; IPR001111; TGF-b_propeptide.
DR InterPro; IPR015615; TGF-beta-rel.
DR InterPro; IPR017948; TGFb_CS.
DR PANTHER; PTHR11848:SF139; BONE MORPHOGENETIC PROTEIN 5; 1.
DR PANTHER; PTHR11848; TGF-BETA FAMILY; 1.
DR Pfam; PF00019; TGF_beta; 1.
DR Pfam; PF00688; TGFb_propeptide; 1.
DR SMART; SM00204; TGFB; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS00250; TGF_BETA_1; 1.
DR PROSITE; PS51362; TGF_BETA_2; 1.
PE 3: Inferred from homology;
KW Cleavage on pair of basic residues {ECO:0000256|ARBA:ARBA00022685};
KW Growth factor {ECO:0000256|ARBA:ARBA00023030,
KW ECO:0000256|RuleBase:RU000354};
KW Reference proteome {ECO:0000313|Proteomes:UP000054116};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..453
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5001877180"
FT DOMAIN 333..453
FT /note="TGF-beta family profile"
FT /evidence="ECO:0000259|PROSITE:PS51362"
FT REGION 317..345
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 326..345
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 453 AA; 51523 MW; 5F8D2E5B8B6D13D8 CRC64;
MNLTALKAFV GLLWNCWVLV GHAQGGLGDN HVHSSFIYRR LRNHERREIQ REILSILGLP
HRPRPFSPGK QAASAPLFML DLYNAMTNEE DTEELEYSLK GSMAGESRGI QKGYPASPNG
YSRRIQLSRM TPLTTQNPPL ASLHDTNFLN DADMVMSFVN LVERDKDFSH QRRHYKEFRF
DLTQIPHGEA VTAAEFRIYK DRSNSRFENE TIQISIYQII KEHPNRDADL FLLDTRKAQA
SDVGWFVFDI TVTSNHWVIN PQNNLGLQLC AETGDGRSIN VKSAGLIGRH GPQSKQPFMV
AFFKASEVLF RSVRAANNKR KNQSRNKSGS HQESSRMPSV ADYNTSEQKQ ACKKHELYVS
FRDLGWQDWI IAPEGYAAFY CDGECSFPLN AHMNATNHAI VQTLVHLMFP DHVPKPCCAP
TKLNAISVLY FDDSSNVILK KYRNMVVRSC GCH
//
