ID   A0A091N579_CARIC        Unreviewed;       842 AA.
AC   A0A091N579;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   27-MAR-2024, entry version 24.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN   ORFNames=N322_03310 {ECO:0000313|EMBL:KFP68865.1};
OS   Cariama cristata (Red-legged seriema).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Cariamiformes; Cariamidae; Cariama.
OX   NCBI_TaxID=54380 {ECO:0000313|EMBL:KFP68865.1, ECO:0000313|Proteomes:UP000054116};
RN   [1] {ECO:0000313|EMBL:KFP68865.1, ECO:0000313|Proteomes:UP000054116}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BGI_N322 {ECO:0000313|EMBL:KFP68865.1};
RA   Zhang G., Li C.;
RT   "Genome evolution of avian class.";
RL   Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-ATPase), a
CC       multimeric enzyme that catalyzes the translocation of protons across
CC       the membranes. Required for assembly and activity of the V-ATPase.
CC       {ECO:0000256|RuleBase:RU361189}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|ARBA:ARBA00009904, ECO:0000256|RuleBase:RU361189}.
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DR   EMBL; KK528091; KFP68865.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A091N579; -.
DR   Proteomes; UP000054116; Unassembled WGS sequence.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0046961; F:proton-transporting ATPase activity, rotational mechanism; IEA:InterPro.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629:SF26; V-TYPE PROTON ATPASE 116 KDA SUBUNIT A 4; 1.
DR   PANTHER; PTHR11629; VACUOLAR PROTON ATPASES; 1.
DR   Pfam; PF01496; V_ATPase_I; 1.
DR   PIRSF; PIRSF001293; ATP6V0A1; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Hydrogen ion transport {ECO:0000256|ARBA:ARBA00022781,
KW   ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW   ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361189};
KW   Reference proteome {ECO:0000313|Proteomes:UP000054116};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM        398..427
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   TRANSMEM        447..466
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   TRANSMEM        545..566
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   TRANSMEM        572..596
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   TRANSMEM        641..662
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   TRANSMEM        773..798
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   REGION          673..711
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          51..120
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        686..711
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   842 AA;  96256 MW;  8395AE11FEEFC082 CRC64;
     MASVFRSEEM SLMQLFLQVE AAYCCVAELG ELGLVQFRDL NVNVNSFQRK FVNEVRRCES
     LERILRFLEN EMEDNVDIVK LKKYPETPLP REMIDMETVL EKLEAELLEA NQNQQTLKQN
     FLELTELKHL LKKTQDFFEA ETNLPDDFFS EDTSGLLELR STPAAAAAKL GFTAGVIKRE
     RMIPFERLLW RACRGNIYLR YTEMDTPLED PVTREEVKKN VFIIFYQGEQ LKQKIKKICD
     GFRATVYPCP ESATERREML DGVNTRIEDL NTVITQTESH RQRLLHEAAA NLWSWGIKVK
     KIKAIYHILN CCNIDVTQQC VIAEIWFPVA DAGRIKRSLH QGMERSGSTI APILTAIHTR
     MAPPTFNRTN KFTAGFQNIV DAYGVGNYRE MNPAPYTIIT FPFLFAVMFG DCGHGAVMLG
     FALWMVINEK SLLAQKSTNE IWNTFFSGRY LILLMGIFSM YTGFIYNDCF SKSFNIFGSS
     WHIIPMFKNS TWNKDVLLDN TVLQLDPAVP GVYSGNPYPF GIDPIWNVAS NKLTFLNSYK
     MKMSVVIGIV HMIFGVILSL FNHIYFKKYI NIILQFIPEM IFIVSLFGYL VFMIIFKWCH
     FDVHSSQSAP SILIHFINMF LFNYGDTSNA PLYLHQKEVQ SFLVIFALIA VPWMLLIKPF
     ILRANHQKAQ RMAQAISGNP GGEDEVDVPE TNHSKKASQG DHSVGHGGHE DDDEEFNFGD
     TFVHQAIHTI EYCLGCISNT ASYLRLWALS LAHAQLSEVL WTMVMHNGFN NSGWAGLIVI
     FIIFAAFAVL TVAILLVMEG LSAFLHALRL HWVEFQNKFY VGAGYKFSPF SFKHIIDGTA
     EE
//