ID   A0A091N629_CARIC        Unreviewed;      1063 AA.
AC   A0A091N629;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   13-SEP-2023, entry version 20.
DE   SubName: Full=Protein patched 1 {ECO:0000313|EMBL:KFP69175.1};
DE   Flags: Fragment;
GN   ORFNames=N322_10179 {ECO:0000313|EMBL:KFP69175.1};
OS   Cariama cristata (Red-legged seriema).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Cariamiformes; Cariamidae; Cariama.
OX   NCBI_TaxID=54380 {ECO:0000313|EMBL:KFP69175.1, ECO:0000313|Proteomes:UP000054116};
RN   [1] {ECO:0000313|EMBL:KFP69175.1, ECO:0000313|Proteomes:UP000054116}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BGI_N322 {ECO:0000313|EMBL:KFP69175.1};
RA   Zhang G., Li C.;
RT   "Genome evolution of avian class.";
RL   Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the patched family.
CC       {ECO:0000256|ARBA:ARBA00005585}.
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DR   EMBL; KK529034; KFP69175.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A091N629; -.
DR   Proteomes; UP000054116; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0008158; F:hedgehog receptor activity; IEA:InterPro.
DR   Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR   InterPro; IPR003392; Ptc/Disp.
DR   InterPro; IPR000731; SSD.
DR   InterPro; IPR004766; TM_rcpt_patched.
DR   NCBIfam; TIGR00918; 2A060602; 1.
DR   PANTHER; PTHR46022; PROTEIN PATCHED; 1.
DR   PANTHER; PTHR46022:SF5; PROTEIN PATCHED HOMOLOG 1; 1.
DR   Pfam; PF02460; Patched; 1.
DR   Pfam; PF12349; Sterol-sensing; 1.
DR   SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR   PROSITE; PS50156; SSD; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Receptor {ECO:0000256|ARBA:ARBA00023170};
KW   Reference proteome {ECO:0000313|Proteomes:UP000054116};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        313..332
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        344..369
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        375..397
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        418..441
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        447..470
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        624..641
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        900..921
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        927..949
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        956..982
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        994..1014
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        1026..1051
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          312..472
FT                   /note="SSD"
FT                   /evidence="ECO:0000259|PROSITE:PS50156"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:KFP69175.1"
FT   NON_TER         1063
FT                   /evidence="ECO:0000313|EMBL:KFP69175.1"
SQ   SEQUENCE   1063 AA;  119305 MW;  27E7D58695277ED0 CRC64;
     DIYPSVGGRV SRELNYTRQK IGEEAMFNPQ LMIQTPQEDG ANVLTTEALR QHLDSALQAS
     RVHVYMYNRQ WKLEHLCYKS GELITEAGYM DQIIEYLYPC LIITPLDCFW EGAKLQSGTA
     YLLGKPPLQW INFDPLEFLE ELKKINYQVE SWEEMLNKAE VGHGYMDRPC LNPADPDCPI
     TAPNKNSTKP LDVALVLSGG CYGLSRKYMH WQEELIIGGT VKNSSGKLVS AQALQTMFQL
     MTPKQMYEHF KGYEYVSHIN WNEDKAAAIL EAWQRMYVEV VHQSVAQNST QKVLSFTTTT
     LDDILKSFSD VSVIRVASGY LLMLAYACLT MLRWDCAKSQ GAVGLAGVLL VALSVAAGLG
     LCSLIGISFN AATTQVLPFL ALGVGVDDVF LLAHAFSETG QNKRIPFEDR TGECLKRTGA
     SVALTSISNV TAFFMAALIP IPALRAFSLQ AAVVVVFNFA MVLLIFPAIL SMDLYRREDR
     RLDIFCCFTS PCVTRVIQIE PQAYVENDNT CYSPPPPYSS HSFAHETQIT MQSTVQLRTE
     YDPHTQVYYT TAEPRSEISV QPVTVTQDNL SCQSPESTSS TRDLLSQFSD SSMHCLEPPC
     TKWTLSSFAE KHYAPFLLKP KAKIVVIFLF LGLLGLSLYG TTRVRDGLDL TDIVPRETRE
     YDFIAAQFKY FSFYNMYIVT QKADYPNVQH LLYELHRSFS NVTYVLLEED RQLPKMWLHY
     FRDWLQGLQD AFDSDWETGK ITYNNYKNGS DDAVLAYKLL VQTGNRAKPI DISQLTKQRL
     VDADGIINPN AFYIYLTAWV SNDPVAYAAS QANIRPHRPE WVHDKADYMP ETRLRIPAAE
     PIEYAQFPFY LNGLRETSDF VEAIEKVRAI CSNYTSLGIA SYPNGYPFLF WEQYIGLRHW
     LLLSISVVLA CTFLVCALFL LNPWTAGIIV VVLALMTVEL FGMMGLIGIK LSAVPVVILI
     ASVGIGVEFT VHVALAFLTA IGDRNHRAVL ALEHMFAPVL DGAVSTLLGV LMLAGSEFDF
     IVRYFFAVLA ILTILGVLNG LVLLPVLLSF FGPYPEVSKI NGE
//