ID A0A091NDJ3_9PASS Unreviewed; 1229 AA.
AC A0A091NDJ3;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 42.
DE RecName: Full=DNA polymerase {ECO:0000256|RuleBase:RU000442};
DE EC=2.7.7.7 {ECO:0000256|RuleBase:RU000442};
DE Flags: Fragment;
GN ORFNames=N310_00449 {ECO:0000313|EMBL:KFP86959.1};
OS Acanthisitta chloris (rifleman).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Passeriformes; Acanthisittidae;
OC Acanthisitta.
OX NCBI_TaxID=57068 {ECO:0000313|EMBL:KFP86959.1, ECO:0000313|Proteomes:UP000053537};
RN [1] {ECO:0000313|EMBL:KFP86959.1, ECO:0000313|Proteomes:UP000053537}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N310 {ECO:0000313|EMBL:KFP86959.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC ChEBI:CHEBI:173112; EC=2.7.7.7;
CC Evidence={ECO:0000256|RuleBase:RU000442};
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the DNA polymerase type-B family.
CC {ECO:0000256|ARBA:ARBA00005755, ECO:0000256|RuleBase:RU000442}.
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DR EMBL; KK845182; KFP86959.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A091NDJ3; -.
DR Proteomes; UP000053537; Unassembled WGS sequence.
DR GO; GO:0031981; C:nuclear lumen; IEA:UniProt.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR GO; GO:1902975; P:mitotic DNA replication initiation; IEA:InterPro.
DR CDD; cd05776; DNA_polB_alpha_exo; 1.
DR CDD; cd05532; POLBc_alpha; 1.
DR Gene3D; 2.40.50.730; -; 1.
DR Gene3D; 3.30.70.2820; -; 1.
DR Gene3D; 1.10.132.60; DNA polymerase family B, C-terminal domain; 1.
DR Gene3D; 1.10.287.690; Helix hairpin bin; 1.
DR Gene3D; 3.90.1600.10; Palm domain of DNA polymerase; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR006172; DNA-dir_DNA_pol_B.
DR InterPro; IPR017964; DNA-dir_DNA_pol_B_CS.
DR InterPro; IPR006133; DNA-dir_DNA_pol_B_exonuc.
DR InterPro; IPR006134; DNA-dir_DNA_pol_B_multi_dom.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR024647; DNA_pol_a_cat_su_N.
DR InterPro; IPR042087; DNA_pol_B_thumb.
DR InterPro; IPR023211; DNA_pol_palm_dom_sf.
DR InterPro; IPR045846; POLBc_alpha.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR NCBIfam; TIGR00592; pol2; 1.
DR PANTHER; PTHR45861; DNA POLYMERASE ALPHA CATALYTIC SUBUNIT; 1.
DR PANTHER; PTHR45861:SF1; DNA POLYMERASE ALPHA CATALYTIC SUBUNIT; 1.
DR Pfam; PF12254; DNA_pol_alpha_N; 1.
DR Pfam; PF00136; DNA_pol_B; 1.
DR Pfam; PF03104; DNA_pol_B_exo1; 1.
DR PRINTS; PR00106; DNAPOLB.
DR SMART; SM00486; POLBc; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR PROSITE; PS00116; DNA_POLYMERASE_B; 1.
PE 3: Inferred from homology;
KW DNA replication {ECO:0000256|RuleBase:RU000442};
KW DNA-binding {ECO:0000256|RuleBase:RU000442};
KW DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932,
KW ECO:0000256|RuleBase:RU000442};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695,
KW ECO:0000256|RuleBase:RU000442};
KW Reference proteome {ECO:0000313|Proteomes:UP000053537};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU000442};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 2..58
FT /note="DNA polymerase alpha catalytic subunit N-terminal"
FT /evidence="ECO:0000259|Pfam:PF12254"
FT DOMAIN 402..700
FT /note="DNA-directed DNA polymerase family B exonuclease"
FT /evidence="ECO:0000259|Pfam:PF03104"
FT DOMAIN 765..1216
FT /note="DNA-directed DNA polymerase family B
FT multifunctional"
FT /evidence="ECO:0000259|Pfam:PF00136"
FT REGION 61..91
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 183..206
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 219..283
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 63..88
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 186..200
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 232..248
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 249..281
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFP86959.1"
FT NON_TER 1229
FT /evidence="ECO:0000313|EMBL:KFP86959.1"
SQ SEQUENCE 1229 AA; 139354 MW; 189385F6586BF00F CRC64;
KKAKAGEKIK YEVEEFTGVY DEVDEDEYSK MVRDRQDDDW IVDDDGIGYI EDGREIFDDD
LDDDALSSNK KRKGGRTSTI DKKKMTKSAV SKPNTIKSMF MASVGKKNTD KTVDLSKDDL
LGDILQDLKA ETVQLSPPPI IMLKRKRSAG VPLNPFSVQS QTSKAITPTS KKAPARLRNE
TLPPASFHSK HLNSASKSVR VPENEDTKYV QKATENGGVV KTAGEKGTED DDQGMMDFDE
EDFDEPMEAE HVETVPETAE SLKGDNEIEK RETEQLESEK KETSVLSCSL PDVSCWDRID
EDEADLVAAE VQLDPNLLPL VNGENGDQVF RFYWLDAYED QYSQPGVVFL FGKVWIDSAN
TYVSCCVTVK NIERTVYLLP RETEMDLSTG KETETPVTIM SVFKEFNDSI SPKYKIMKFK
SKKVEKYYAF EIPDVPAKSE YLEVKYSAEC PRLPQDLKGR TFSHVFGTNT SSLELLLMSQ
KIKGPCWLEI KNPQPSNLSV SWCKVEAVAM KPVLVNVVKD LSPPPPLVVM SLSMKTTQNP
KTHQNEVVAL AALVHQKFPL DKAPPQPPFQ THFCAVSKPN DCIFPYDFKE AIKRKNAKIE
IAATERTLLG FFLAKIHKID PDVVVGHNIY GFDLEVLLQR INLCKVPHWS KIGRLRRSNM
PKLGGRGGFA ERNAACGRMI CDVEISAREL IRCKSYHLSE LVRQILKTER ATILPEEIRN
MYSDSPRLLF MLENTWIDAK FILQIMCELN VLPLALQITN ISGNVMSRTM MGGRSERNEF
LLLHAFHEKD YIVPDKQMFK KPPQKLVDED EDFEDQNKSK IGKKKAAYAG GLVLDPKVGF
YDKFILLLDF NSLYPSIIQE FNICFTTVQR LSSEAQKRAE VEEEEEIPEL PDPSLEMGIL
PKEIRKLVER RCQVKQLMKQ PDLNPDLYLQ YDIRQKALKL TANSMYGCLG FSYSRFYAKP
LAALVTHKGR EILMHTKEMV QKMNLEVIYG DTDSIMINTN STNLDEVFKL GNKIKSEVNK
LYKLLEIDID GIFKSLLLLK KKKYAALVVE PTGDGKYVTK QELKGLDIVR RDWCDLAKET
GNYVIGQILS DQPRDIIVEN IQKRLIEIGE NVTNGQIPVN QFEIYKALTK DPQDYPDKKS
LPHVHVAMWI NSQGGRKVKA GDTVSYIICQ DGSGLSASQR AYAPEQLQKQ ENLTIDIQYY
LSQQIHPVVA RICEPIEGID SVLIATWLG
//
