ID A0A091NHU3_APAVI Unreviewed; 478 AA.
AC A0A091NHU3;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 24-JAN-2024, entry version 46.
DE RecName: Full=Muscarinic acetylcholine receptor {ECO:0000256|RuleBase:RU361191};
GN ORFNames=N311_05515 {ECO:0000313|EMBL:KFP89313.1};
OS Apaloderma vittatum (Bar-tailed trogon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Trogoniformes; Trogonidae; Apaloderma.
OX NCBI_TaxID=57397 {ECO:0000313|EMBL:KFP89313.1, ECO:0000313|Proteomes:UP000054244};
RN [1] {ECO:0000313|EMBL:KFP89313.1, ECO:0000313|Proteomes:UP000054244}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N311 {ECO:0000313|EMBL:KFP89313.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: The muscarinic acetylcholine receptor mediates various
CC cellular responses, including inhibition of adenylate cyclase,
CC breakdown of phosphoinositides and modulation of potassium channels
CC through the action of G proteins. {ECO:0000256|RuleBase:RU361191}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU361191};
CC Multi-pass membrane protein {ECO:0000256|RuleBase:RU361191}.
CC Postsynaptic cell membrane {ECO:0000256|RuleBase:RU361191}; Multi-pass
CC membrane protein {ECO:0000256|RuleBase:RU361191}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}. Synaptic cell membrane
CC {ECO:0000256|ARBA:ARBA00034099}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00034099}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC Muscarinic acetylcholine receptor subfamily.
CC {ECO:0000256|RuleBase:RU361191}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU361191}.
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DR EMBL; KL384119; KFP89313.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A091NHU3; -.
DR Proteomes; UP000054244; Unassembled WGS sequence.
DR GO; GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016907; F:G protein-coupled acetylcholine receptor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0040012; P:regulation of locomotion; IEA:InterPro.
DR CDD; cd15298; 7tmA_mAChR_M4; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 2.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR001432; Musac_Ach_M4_rcpt.
DR InterPro; IPR000995; Musac_Ach_rcpt.
DR PANTHER; PTHR24247; 5-HYDROXYTRYPTAMINE RECEPTOR; 1.
DR PANTHER; PTHR24247:SF180; MUSCARINIC ACETYLCHOLINE RECEPTOR M4; 1.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00243; MUSCARINICR.
DR PRINTS; PR00541; MUSCRINICM4R.
DR SMART; SM01381; 7TM_GPCR_Srsx; 1.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475,
KW ECO:0000256|RuleBase:RU361191};
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040,
KW ECO:0000256|RuleBase:RU000688};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361191};
KW Postsynaptic cell membrane {ECO:0000256|RuleBase:RU361191};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU000688};
KW Reference proteome {ECO:0000313|Proteomes:UP000054244};
KW Synapse {ECO:0000256|RuleBase:RU361191};
KW Transducer {ECO:0000256|ARBA:ARBA00023224, ECO:0000256|RuleBase:RU000688};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU000688};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU361191}.
FT TRANSMEM 30..55
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361191"
FT TRANSMEM 67..93
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361191"
FT TRANSMEM 105..126
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361191"
FT TRANSMEM 147..172
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361191"
FT TRANSMEM 192..216
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361191"
FT TRANSMEM 397..415
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361191"
FT DOMAIN 47..452
FT /note="G-protein coupled receptors family 1 profile"
FT /evidence="ECO:0000259|PROSITE:PS50262"
FT REGION 247..329
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 292..307
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 314..329
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 478 AA; 53621 MW; 9086A9E2CEFF2DDA CRC64;
MANLTYDNFT LGNHSEVAIQ PPTNYKTVEL VFIATVTGSL SLVTVVGNIL VMLSIKVNRQ
LQTVNNYFLF SLACADLIIG VFSMNLYTVY IIKGYWPLGA VVCDLWLALD YVVSNASVMN
LLIISFDRYF CVTKPLTYPA RRTTKMAGLM IAAAWILSFI LWAPAILFWQ FIVGKRTVPE
RECYIQFLSN PAVTFGTAIA AFYLPVVIMT VLYIHISLAS RSRVRRHKPE SRKEMKNKSL
RFFKGPLIKQ NNNNSPKRAV EVKEEVRNGK VDDQPSAQTE ATGHQEEKET SNESSTVSMT
QTTKDKPTAE ILPAGQGQTP SQPRVNPSSK WSKIKIVTKQ TGTECVTAIE IVPAKAGGSD
HNSLANSRPV NVARKFASIA RSQVRKKRQM AAREKKVTRT IFAILLAFIL TWTPYNVMVL
INTFCETCVP ETVWSIGYWL CYVNSTINPA CYALCNATFK KTFKHLLMCQ YRNIGTAR
//
