ID A0A091NJG1_APAVI Unreviewed; 354 AA.
AC A0A091NJG1;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=Ubiquitin carboxyl-terminal hydrolase 46 {ECO:0000256|ARBA:ARBA00039415};
DE EC=3.4.19.12 {ECO:0000256|ARBA:ARBA00012759};
DE AltName: Full=Deubiquitinating enzyme 46 {ECO:0000256|ARBA:ARBA00042431};
DE AltName: Full=Ubiquitin thioesterase 46 {ECO:0000256|ARBA:ARBA00041292};
DE AltName: Full=Ubiquitin-specific-processing protease 46 {ECO:0000256|ARBA:ARBA00042999};
DE Flags: Fragment;
GN ORFNames=N311_02437 {ECO:0000313|EMBL:KFP89903.1};
OS Apaloderma vittatum (Bar-tailed trogon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Trogoniformes; Trogonidae; Apaloderma.
OX NCBI_TaxID=57397 {ECO:0000313|EMBL:KFP89903.1, ECO:0000313|Proteomes:UP000054244};
RN [1] {ECO:0000313|EMBL:KFP89903.1, ECO:0000313|Proteomes:UP000054244}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N311 {ECO:0000313|EMBL:KFP89903.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide
CC and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-
CC residue protein attached to proteins as an intracellular targeting
CC signal).; EC=3.4.19.12; Evidence={ECO:0000256|ARBA:ARBA00000707};
CC -!- SIMILARITY: Belongs to the peptidase C19 family. USP12/USP46 subfamily.
CC {ECO:0000256|ARBA:ARBA00038282}.
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DR EMBL; KL385865; KFP89903.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A091NJG1; -.
DR Proteomes; UP000054244; Unassembled WGS sequence.
DR GO; GO:0004843; F:cysteine-type deubiquitinase activity; IEA:InterPro.
DR GO; GO:0007610; P:behavior; IEA:UniProtKB-KW.
DR CDD; cd02663; Peptidase_C19G; 1.
DR Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR001394; Peptidase_C19_UCH.
DR InterPro; IPR018200; USP_CS.
DR InterPro; IPR028889; USP_dom.
DR PANTHER; PTHR24006; UBIQUITIN CARBOXYL-TERMINAL HYDROLASE; 1.
DR PANTHER; PTHR24006:SF714; UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 46; 1.
DR Pfam; PF00443; UCH; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR PROSITE; PS00972; USP_1; 1.
DR PROSITE; PS00973; USP_2; 1.
DR PROSITE; PS50235; USP_3; 1.
PE 3: Inferred from homology;
KW Behavior {ECO:0000256|ARBA:ARBA00022610};
KW Hydrolase {ECO:0000313|EMBL:KFP89903.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000054244}.
FT DOMAIN 23..353
FT /note="USP"
FT /evidence="ECO:0000259|PROSITE:PS50235"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFP89903.1"
FT NON_TER 354
FT /evidence="ECO:0000313|EMBL:KFP89903.1"
SQ SEQUENCE 354 AA; 41157 MW; 6AA80CBFD5BA14D8 CRC64;
GTNASALEKD IGPEQFPINE HYFGLVNFGN TCYCNSVLQA LYFCRPFREN VLSYKAQQKK
KENLLTCLAD LFHSIATQKK KVGVIPPKKF ISRLRKENDL FDNYMQQDAH EFLNYLLNTI
ADILQEEKKQ EKQNGKLKNG NMNEAEENNK QELTWVHEIF QGTLTNETRC LNCETVSSKD
EDFLDLSVDV EQNTSITHCL RDFSNTETLC SEQKYYCETC CSKQEAQKRM RVKKLPMILA
LHLKRFKYME QLHRYTKLSY RVVFPLELRL FNTSGDAVNL DRMYDLVAVV VHCGSGPNRG
HYITIVKSHG FWLLFDDDIV EKIDAQAIEE FYGLTSDISK NSESGYILFY QSRE
//
