ID   A0A091P2R1_HALAL        Unreviewed;       502 AA.
AC   A0A091P2R1;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   27-MAR-2024, entry version 28.
DE   SubName: Full=DNA topoisomerase 2-binding protein 1 {ECO:0000313|EMBL:KFQ01856.1};
GN   ORFNames=N329_11160 {ECO:0000313|EMBL:KFQ01856.1};
OS   Haliaeetus albicilla (White-tailed sea-eagle) (Falco albicilla).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Accipitriformes; Accipitridae;
OC   Accipitrinae; Haliaeetus.
OX   NCBI_TaxID=8969 {ECO:0000313|EMBL:KFQ01856.1, ECO:0000313|Proteomes:UP000054379};
RN   [1] {ECO:0000313|EMBL:KFQ01856.1, ECO:0000313|Proteomes:UP000054379}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BGI_N329 {ECO:0000313|EMBL:KFQ01856.1};
RA   Zhang G., Li C.;
RT   "Genome evolution of avian class.";
RL   Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR   EMBL; KK651245; KFQ01856.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A091P2R1; -.
DR   Proteomes; UP000054379; Unassembled WGS sequence.
DR   GO; GO:0005694; C:chromosome; IEA:UniProt.
DR   GO; GO:0005634; C:nucleus; IEA:UniProt.
DR   GO; GO:0016853; F:isomerase activity; IEA:UniProtKB-KW.
DR   CDD; cd17737; BRCT_TopBP1_rpt1; 1.
DR   CDD; cd17731; BRCT_TopBP1_rpt2_like; 1.
DR   CDD; cd17718; BRCT_TopBP1_rpt3; 1.
DR   Gene3D; 3.40.50.10190; BRCT domain; 4.
DR   InterPro; IPR001357; BRCT_dom.
DR   InterPro; IPR036420; BRCT_dom_sf.
DR   InterPro; IPR049542; TopBP1-like_BRCT0.
DR   InterPro; IPR044737; TopBP1_BRCT_1.
DR   PANTHER; PTHR13561; DNA REPLICATION REGULATOR DPB11-RELATED; 1.
DR   PANTHER; PTHR13561:SF20; DNA TOPOISOMERASE 2-BINDING PROTEIN 1; 1.
DR   Pfam; PF00533; BRCT; 2.
DR   Pfam; PF12738; PTCB-BRCT; 1.
DR   Pfam; PF21298; TopBP1_BRCT0; 1.
DR   SMART; SM00292; BRCT; 4.
DR   SUPFAM; SSF52113; BRCT domain; 3.
DR   PROSITE; PS50172; BRCT; 3.
PE   4: Predicted;
KW   Isomerase {ECO:0000313|EMBL:KFQ01856.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000054379}.
FT   DOMAIN          120..171
FT                   /note="BRCT"
FT                   /evidence="ECO:0000259|PROSITE:PS50172"
FT   DOMAIN          193..282
FT                   /note="BRCT"
FT                   /evidence="ECO:0000259|PROSITE:PS50172"
FT   DOMAIN          353..443
FT                   /note="BRCT"
FT                   /evidence="ECO:0000259|PROSITE:PS50172"
SQ   SEQUENCE   502 AA;  56881 MW;  D6C81D1D4B0018DB CRC64;
     MKGSKELFFV KFIKSSGNSE YFFKALESIK EFQSEEHLQI LEEETALNIK ENDKSLYICD
     PFKGVVFSHL KKLGCRIVGP QVVLYCMQSQ QCVPRAECPV YNMTMADVTV SCTSLEKDVR
     EEVHKYVQMM GGCVSRDLSV SVTHLVAGEV GSRKYLVAAS LKKPVLLPSW VKTLWDKSQQ
     SIMRYTDVNM EDYACPVFLG CTICVTGLSS SERKEVQRLT AEHGGQYTGR LKMNECTHLI
     VQEPKGQKYE CARKWNVHCV SVQWFSDSIA KGFCQDETIY KIESGSKLSN MPNTSTPTND
     ARKPDNHTFS DVSHISNINS SSVNETARSS AMSSRLDPLP DELENLDISS FQDPEDLLDG
     CRIYLCGFSG RKLDKMRRLI NCGGGVRFNQ LNEDVTHVIL GENNDELKHF LDKTAHRPHV
     VTAKWLLESF SKGYLHPVEQ YVPLNYQLLE NPILEQPGMK SILPKNNNLL KKEAMNVRKH
     RKAAEEDFLS QYVNNDSTMG TF
//