ID   A0A091P2Y8_HALAL        Unreviewed;      1341 AA.
AC   A0A091P2Y8;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   22-FEB-2023, entry version 26.
DE   SubName: Full=Patched domain-containing protein 2 {ECO:0000313|EMBL:KFQ01409.1};
GN   ORFNames=N329_07038 {ECO:0000313|EMBL:KFQ01409.1};
OS   Haliaeetus albicilla (White-tailed sea-eagle) (Falco albicilla).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Accipitriformes; Accipitridae;
OC   Accipitrinae; Haliaeetus.
OX   NCBI_TaxID=8969 {ECO:0000313|EMBL:KFQ01409.1, ECO:0000313|Proteomes:UP000054379};
RN   [1] {ECO:0000313|EMBL:KFQ01409.1, ECO:0000313|Proteomes:UP000054379}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BGI_N329 {ECO:0000313|EMBL:KFQ01409.1};
RA   Zhang G., Li C.;
RT   "Genome evolution of avian class.";
RL   Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR   EMBL; KK650375; KFQ01409.1; -; Genomic_DNA.
DR   Proteomes; UP000054379; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR   InterPro; IPR042480; DISP3.
DR   InterPro; IPR004869; MMPL_dom.
DR   InterPro; IPR003392; Ptc/Disp.
DR   InterPro; IPR000731; SSD.
DR   PANTHER; PTHR46687; PROTEIN DISPATCHED HOMOLOG 3; 1.
DR   PANTHER; PTHR46687:SF1; PROTEIN DISPATCHED HOMOLOG 3; 1.
DR   Pfam; PF03176; MMPL; 1.
DR   Pfam; PF02460; Patched; 1.
DR   SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR   PROSITE; PS50156; SSD; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000054379};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        68..88
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        413..430
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        436..459
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        466..488
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        508..528
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        540..566
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        679..696
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        1132..1150
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        1156..1177
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        1238..1264
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        1270..1293
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        1305..1327
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          460..565
FT                   /note="SSD"
FT                   /evidence="ECO:0000259|PROSITE:PS50156"
FT   REGION          168..197
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          753..776
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1341 AA;  148631 MW;  82C52E2A38A9AA15 CRC64;
     MDTEDDPLLQ DAWLDEEDEE VAFSSRKRRE GALLCGKSPC KVRPLRVTLP VSGFWNIVGW
     VFTNPYCAGF ILFLGCAIPA VLAVVMFLHY PALDIDISYN AFEIRNHESS QRFDALALAL
     KSQFGSWGRN RRDLADFTSE TLQRLIFEQL QQLHLNASHL GVSTHVKRSI PEGRTSSPKP
     RVHLNPGNRS SRTGRGAPRW DYSSTYISAN TQTHAHWRIE LIFLARGDSE NNIFTTERLV
     TIHEVERKIM DHPRFREFCW KPHEVLKDLP LGSYSYCSPP SSLMTYFFPT ERGGKIYYDG
     MGQDLADIQG ELRAMGSLEL AMTHPEFYWY VDEGLSAENM KSSLLRSEIL FGAPLPNYYS
     VEDRWEEQRR KFQNFVITYV AMLAKQSTSK VQVLYGGTDL FDYEVRRTFN NDMLLAFISS
     SCIAVLVYIL TSCSVFLSFF GIASIGLSCL VALFLYHVVF GIQYLGILNG VAAFVIVGIG
     VDDVFVFINT YRQATHLKDL RLRMIHTIQT AGKATFFTSL TTAAAYAANI FSQIPAVHDF
     GLFMSLIVSC CWVAVLFTMP AALGIWTLYV SPLESSCQTS CSQKCTKKSA LHLAEDLFIA
     SEATSRAGRE TLPYLDDDIP LLSVEEEPGS LEMGDVPLVS VMPENLQLPV EKSNRGQLIT
     HLQELLEHWV LWSAVKSRWV IVGLFLLVLL LSIFFASRLH PASRAPVLFR PDTNIQVLLD
     LKYNLSAEGI SCITCSGLFQ EKPHSLQNNI RTSLEKKKRG SGSPWGSKGS ISDTGQQDLQ
     GTVYISKSRS KGRPAIYRFS LNASVPAPWQ MVSPGDGEVP SFQVYRVPFG NFTRKLTACV
     STVGLLKQTS PRKWMMTTLS CDTKRGWKFD FSFYVAAKEQ QRTRKLYFAQ SHKPPYHGRV
     CVAPPGCLLS SSPDGPTKGI LYVPSEKAPK AKLSATSGFN PCMNTGCGKP AVRPLVDTGA
     MVFVVFGIRG VNRTRRPDNH VIGDMGSVIY DDSFDLFKEI GNLCRLCKAI ASNTELVKPG
     GAQCLPSGYS ISSFLQMLHP ECKNIPEPNL LPGQLSHGAV GVKDGKVQWI SMAFESTTYK
     GKSSFQTYAD YLKWETFLQQ QLQLFPEGSA LRHGFQTCEH WKQIFMEIIG NALYGLVLSL
     VICVAAVAVF TTHILLLLPV LLSILGVVCL VVTIMYWSGW EMGAVEAISL SILVGSSVDY
     CVHLVEGYLL AGENLPLHQA EDPTACRQWR TIEAVRHVGV AIVSSAVTTV IATIPLFFCI
     IAPFAKFGKI VALNTGVSIL YTLTVSTALL SIMGPGTFIR SRTSCLKAVV GVLLAGLLGL
     CICLALLKSG FKIPLPNGTA L
//