ID A0A091P3E9_HALAL Unreviewed; 521 AA.
AC A0A091P3E9;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 24-JAN-2024, entry version 39.
DE SubName: Full=Epidermal growth factor-like 6 {ECO:0000313|EMBL:KFQ01421.1};
DE Flags: Fragment;
GN ORFNames=N329_07735 {ECO:0000313|EMBL:KFQ01421.1};
OS Haliaeetus albicilla (White-tailed sea-eagle) (Falco albicilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Accipitriformes; Accipitridae;
OC Accipitrinae; Haliaeetus.
OX NCBI_TaxID=8969 {ECO:0000313|EMBL:KFQ01421.1, ECO:0000313|Proteomes:UP000054379};
RN [1] {ECO:0000313|EMBL:KFQ01421.1, ECO:0000313|Proteomes:UP000054379}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N329 {ECO:0000313|EMBL:KFQ01421.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the nephronectin family.
CC {ECO:0000256|ARBA:ARBA00009738}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR EMBL; KK650411; KFQ01421.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A091P3E9; -.
DR Proteomes; UP000054379; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:InterPro.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR CDD; cd00054; EGF_CA; 2.
DR CDD; cd06263; MAM; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR Gene3D; 2.10.25.10; Laminin; 5.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR024731; EGF_dom.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR000998; MAM_dom.
DR PANTHER; PTHR24050:SF24; EPIDERMAL GROWTH FACTOR-LIKE PROTEIN 6; 1.
DR PANTHER; PTHR24050; PA14 DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF12947; EGF_3; 1.
DR Pfam; PF07645; EGF_CA; 2.
DR Pfam; PF00629; MAM; 1.
DR SMART; SM00181; EGF; 5.
DR SMART; SM00179; EGF_CA; 3.
DR SMART; SM00137; MAM; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 1.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR PROSITE; PS00010; ASX_HYDROXYL; 3.
DR PROSITE; PS00022; EGF_1; 1.
DR PROSITE; PS01186; EGF_2; 2.
DR PROSITE; PS50026; EGF_3; 2.
DR PROSITE; PS01187; EGF_CA; 1.
DR PROSITE; PS50060; MAM_2; 1.
PE 3: Inferred from homology;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Reference proteome {ECO:0000313|Proteomes:UP000054379};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 70..109
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 150..188
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 373..519
FT /note="MAM"
FT /evidence="ECO:0000259|PROSITE:PS50060"
FT REGION 306..330
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 311..328
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFQ01421.1"
FT NON_TER 521
FT /evidence="ECO:0000313|EMBL:KFQ01421.1"
SQ SEQUENCE 521 AA; 58087 MW; E23C61A7E06D6F2E CRC64;
SSRARGQLVA VSQPGVCRYG SRLDCCYGWK KNNKGHCEAV CGHGCKYGEC MGPNKCKCFP
GFTGKTCNQD LNECGLKPRP CEHRCMNTHG SYKCYCLNGY MLMPDGTCAS SRTCAVVNCQ
YGCEEVKGEV QCLCPSGGLQ LGPNRRTCID IDECSAGKAV CSYNRRCINT FGSYYCKCQL
GYELKYVSGR YDCVAAKNEA IWIKYKCNLH AECLNTEGSF KCKCKQGYRG SGFDCVVIPE
KSVKEIARIP GTAKDRIKKL LAHKNSVKKH ETIKNAIPEA AVTPSSKTHS QLLDYEGGID
LGRSYNEEEK ETEATAEEEA EESDEEKEDF ENRIAHERSL RGDVFFPKVK EAAAFSPLLA
QRKVPVSRPE QEVDCSFSRG VCDWKQDADD DFDWNPADRD RGDGYYMAVP AFVGHKKDMG
RLKLLLTDLK PKSSYCLIFS YRLAGERVGK LRVFLANKKT APVWEQNKGK DERWRTGKVE
IFQGAETTNS VTFESERGKG KTGEIAVDNV ILISGLCPED T
//
