ID   A0A091P5I2_HALAL        Unreviewed;       396 AA.
AC   A0A091P5I2;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   27-MAR-2024, entry version 32.
DE   SubName: Full=Methyltransferase-like 2 {ECO:0000313|EMBL:KFQ03232.1};
DE   Flags: Fragment;
GN   ORFNames=N329_01792 {ECO:0000313|EMBL:KFQ03232.1};
OS   Haliaeetus albicilla (White-tailed sea-eagle) (Falco albicilla).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Accipitriformes; Accipitridae;
OC   Accipitrinae; Haliaeetus.
OX   NCBI_TaxID=8969 {ECO:0000313|EMBL:KFQ03232.1, ECO:0000313|Proteomes:UP000054379};
RN   [1] {ECO:0000313|EMBL:KFQ03232.1, ECO:0000313|Proteomes:UP000054379}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BGI_N329 {ECO:0000313|EMBL:KFQ03232.1};
RA   Zhang G., Li C.;
RT   "Genome evolution of avian class.";
RL   Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the methyltransferase superfamily. METL family.
CC       {ECO:0000256|ARBA:ARBA00009725}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; KK653432; KFQ03232.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A091P5I2; -.
DR   Proteomes; UP000054379; Unassembled WGS sequence.
DR   GO; GO:0008173; F:RNA methyltransferase activity; IEA:UniProt.
DR   GO; GO:0008757; F:S-adenosylmethionine-dependent methyltransferase activity; IEA:UniProt.
DR   GO; GO:0001510; P:RNA methylation; IEA:UniProt.
DR   GO; GO:0008033; P:tRNA processing; IEA:UniProtKB-KW.
DR   CDD; cd02440; AdoMet_MTases; 1.
DR   Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR   InterPro; IPR013217; Methyltransf_12.
DR   InterPro; IPR026113; METTL2/6/8-like.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   PANTHER; PTHR22809; METHYLTRANSFERASE-RELATED; 1.
DR   PANTHER; PTHR22809:SF3; TRNA N(3)-METHYLCYTIDINE METHYLTRANSFERASE METTL8, MITOCHONDRIAL; 1.
DR   Pfam; PF08242; Methyltransf_12; 1.
DR   PIRSF; PIRSF037755; Mettl2_prd; 1.
DR   SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
PE   3: Inferred from homology;
KW   Methyltransferase {ECO:0000313|EMBL:KFQ03232.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000054379};
KW   Transferase {ECO:0000313|EMBL:KFQ03232.1};
KW   tRNA processing {ECO:0000256|ARBA:ARBA00022694}.
FT   DOMAIN          207..311
FT                   /note="Methyltransferase type 12"
FT                   /evidence="ECO:0000259|Pfam:PF08242"
FT   REGION          119..146
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        129..143
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:KFQ03232.1"
FT   NON_TER         396
FT                   /evidence="ECO:0000313|EMBL:KFQ03232.1"
SQ   SEQUENCE   396 AA;  46101 MW;  DE97C49C1662959B CRC64;
     NFITRLSALC LRKSKMQQRH QSSRRPAVPL GSRILTDPSK VFEHNMWDHM QWSQEEEENA
     RKKAAENSLV KVQWEDQDKY EREASKYWNE FYKTHKNNFF KDRNWLFLEF PEILPEKRRE
     ELQTEQRSSE HTKINSTNSF SHKNEMSEEG EKYWKKNYGG GSTSVQGYVY NKKQAKSLTD
     NPQGKNCGEE LGRLESFPGS DATYRILEVG CGAGNSVFPI LKVLCNTPGT FLYCCDFASG
     AVELVKSHSS YNSAWCSAFV HDVCDDALPY PFPDEILDVI LLVFVLSTIH PDRMQGVVNR
     LAKLLKPGGM LLFRDYGRYD TAQLRFKKGH CLSENFYVRG DGTRVYFFTK DEVWNMFNLA
     GLTEVQNLVD RRLQVNRKKK VKMQRVWIQS KFQKPL
//