ID A0A091P5J3_9PASS Unreviewed; 741 AA.
AC A0A091P5J3;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 24-JAN-2024, entry version 43.
DE SubName: Full=Guanine nucleotide exchange factor VAV3 {ECO:0000313|EMBL:KFP86830.1};
DE Flags: Fragment;
GN ORFNames=N310_07006 {ECO:0000313|EMBL:KFP86830.1};
OS Acanthisitta chloris (rifleman).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Passeriformes; Acanthisittidae;
OC Acanthisitta.
OX NCBI_TaxID=57068 {ECO:0000313|EMBL:KFP86830.1, ECO:0000313|Proteomes:UP000053537};
RN [1] {ECO:0000313|EMBL:KFP86830.1, ECO:0000313|Proteomes:UP000053537}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N310 {ECO:0000313|EMBL:KFP86830.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; KK845057; KFP86830.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A091P5J3; -.
DR Proteomes; UP000053537; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd20869; C1_VAV3; 1.
DR CDD; cd01223; PH_Vav; 1.
DR CDD; cd00160; RhoGEF; 1.
DR CDD; cd11981; SH3_VAV3_1; 1.
DR CDD; cd11978; SH3_VAV3_2; 1.
DR Gene3D; 3.30.60.20; -; 1.
DR Gene3D; 1.10.418.10; Calponin-like domain; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 2.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR001331; GDS_CDC24_CS.
DR InterPro; IPR002219; PE/DAG-bd.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR037832; PH_Vav.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR047015; VAV3_SH3_1.
DR InterPro; IPR035734; VAV3_SH3_2.
DR PANTHER; PTHR45818:SF1; GUANINE NUCLEOTIDE EXCHANGE FACTOR VAV3; 1.
DR PANTHER; PTHR45818; PROTEIN VAV; 1.
DR Pfam; PF00130; C1_1; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR Pfam; PF00017; SH2; 1.
DR Pfam; PF07653; SH3_2; 2.
DR PRINTS; PR00401; SH2DOMAIN.
DR PRINTS; PR00452; SH3DOMAIN.
DR SMART; SM00109; C1; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SMART; SM00252; SH2; 1.
DR SMART; SM00326; SH3; 2.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR SUPFAM; SSF50044; SH3-domain; 2.
DR PROSITE; PS00741; DH_1; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50001; SH2; 1.
DR PROSITE; PS50002; SH3; 2.
DR PROSITE; PS00479; ZF_DAG_PE_1; 1.
DR PROSITE; PS50081; ZF_DAG_PE_2; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000053537};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}; Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 86..265
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 294..396
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 407..456
FT /note="Phorbol-ester/DAG-type"
FT /evidence="ECO:0000259|PROSITE:PS50081"
FT DOMAIN 488..556
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 574..668
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 683..741
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFP86830.1"
FT NON_TER 741
FT /evidence="ECO:0000313|EMBL:KFP86830.1"
SQ SEQUENCE 741 AA; 85431 MW; 4EF51A7E37C1A657 CRC64;
QVIETLSKLS RTPIALGTGI RPFPTEESVD DEDIYKGLPD LLDETGVDED EELYDCVYGE
DEGGEVYEDL MKDEAAQQPK CTENDIRSCC LAEIKQTEEK YTETLESIEK FFMVPLKRFL
SASEFDTVFI NIPDLVKIHR NLTQDINDSI INKNDQNLYQ IFISYKERLV IYGQYCSQVE
IAISCLDNIS KTKEDVKLKL EECSKRANNG KFTLRDLLVV PMQRVLKYHL LLQELVKHTT
DPMEKANLKL ALDAMKDLAQ YVNEVKRDNE TLREIRQFQL SIENLNHSLL QYGRPQGDGE
IRITTLDKRA RQDRHIFLFD LAVIVCKRRG DNYEMKEIID LQKYKITNNP TTDKENKKWS
YGFYLIHIQG ENGLEVYCKT KDLKKKWLEQ FQMALSNIRP DYADTSYHEF KMHTFSRVTS
CKVCQMLLRG TFYQGYLCSK CGAGAHKECL GRLDNCGRAN SGGLSYLNGP VILVKASSEI
PNRHPKCCCL PKMQVIRNYS GIPQPAAQDG PPLHIQIGDT IELIRGDAHS LFWQGRNLTT
GELGFFPSDA VKPCPYLWSF GKKPKAIFIF LCSRFAGAME RLQAESELIN RVNSTYLVRH
RTKESGEYAI SIKYNNEVKH IKILTRDGFF HIAENRKFKN LMELVEYYKH HSLKEGFRSL
DTTLQFPYKE SENSVGQRML SPKVIGIAIA RYDFCARDMR ELSLLKGDVV KIYTKMSANG
WWRGEVNGRV GWFPSTYVEE D
//
