ID A0A091P5T7_HALAL Unreviewed; 205 AA.
AC A0A091P5T7;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=Cytotoxic T-lymphocyte protein 4 {ECO:0000256|ARBA:ARBA00016331};
DE AltName: Full=Cytotoxic T-lymphocyte-associated antigen 4 {ECO:0000256|ARBA:ARBA00032097};
GN Name=Ctla4 {ECO:0000313|EMBL:NWZ58486.1};
GN ORFNames=HALALB_R10381 {ECO:0000313|EMBL:NWZ58486.1}, N329_11037
GN {ECO:0000313|EMBL:KFQ02701.1};
OS Haliaeetus albicilla (White-tailed sea-eagle) (Falco albicilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Accipitriformes; Accipitridae;
OC Accipitrinae; Haliaeetus.
OX NCBI_TaxID=8969 {ECO:0000313|EMBL:KFQ02701.1, ECO:0000313|Proteomes:UP000054379};
RN [1] {ECO:0000313|EMBL:KFQ02701.1, ECO:0000313|Proteomes:UP000054379}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N329 {ECO:0000313|EMBL:KFQ02701.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:NWZ58486.1, ECO:0000313|Proteomes:UP000585422}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=OUT-0040 {ECO:0000313|EMBL:NWZ58486.1};
RC TISSUE=Blood {ECO:0000313|EMBL:NWZ58486.1};
RA Zhang G.;
RT "Bird 10,000 Genomes (B10K) Project - Family phase.";
RL Submitted (SEP-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Inhibitory receptor acting as a major negative regulator of
CC T-cell responses. The affinity of CTLA4 for its natural B7 family
CC ligands, CD80 and CD86, is considerably stronger than the affinity of
CC their cognate stimulatory coreceptor CD28.
CC {ECO:0000256|ARBA:ARBA00002230}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251};
CC Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
CC Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane
CC protein {ECO:0000256|ARBA:ARBA00004479}.
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DR EMBL; KK652678; KFQ02701.1; -; Genomic_DNA.
DR EMBL; VZSQ01000274; NWZ58486.1; -; Genomic_DNA.
DR RefSeq; XP_009915771.1; XM_009917469.1.
DR GeneID; 104316869; -.
DR KEGG; hald:104316869; -.
DR CTD; 1493; -.
DR OrthoDB; 4108912at2759; -.
DR Proteomes; UP000054379; Unassembled WGS sequence.
DR Proteomes; UP000585422; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0002250; P:adaptive immune response; IEA:UniProtKB-KW.
DR GO; GO:0042129; P:regulation of T cell proliferation; IEA:InterPro.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR InterPro; IPR008096; CTLA4.
DR InterPro; IPR040216; CTLA4/CD28.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR013106; Ig_V-set.
DR PANTHER; PTHR11494; CYTOTOXIC T-LYMPHOCYTE PROTEIN; 1.
DR PANTHER; PTHR11494:SF8; CYTOTOXIC T-LYMPHOCYTE PROTEIN 4; 1.
DR Pfam; PF07686; V-set; 1.
DR PRINTS; PR01720; CTLANTIGEN4.
DR SMART; SM00409; IG; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
PE 4: Predicted;
KW Adaptive immunity {ECO:0000256|ARBA:ARBA00023130};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Immunity {ECO:0000256|ARBA:ARBA00022859};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000054379};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..205
FT /note="Cytotoxic T-lymphocyte protein 4"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5040666233"
FT TRANSMEM 146..170
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 26..136
FT /note="Immunoglobulin subtype"
FT /evidence="ECO:0000259|SMART:SM00409"
SQ SEQUENCE 205 AA; 22865 MW; 036E7C3529E30574 CRC64;
MLSVLVTMGF LCTATAIAEV MEVTQPAMVL ANRQGVASLV CKYKHIGNAK EIRVTLLKQT
GDRFTEICAS TYTMEFKMFS VEEVIQCHVS PGRNNVTLTL TGLQANDTGL YVCKMERMYP
PPYFMNKGNG THLYVIDPEP CPDTAIYLWV LGATASGFFL YSIIISAILV HKAVKRRRCL
TTGVYVKMPS EKLEKKVIPF HITVN
//
