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Database: UniProt
Entry: A0A091PIV1_HALAL
LinkDB: A0A091PIV1_HALAL
Original site: A0A091PIV1_HALAL 
ID   A0A091PIV1_HALAL        Unreviewed;       422 AA.
AC   A0A091PIV1;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   31-JUL-2019, entry version 23.
DE   SubName: Full=G protein-activated inward rectifier potassium channel 2 {ECO:0000313|EMBL:KFQ07565.1};
DE   Flags: Fragment;
GN   ORFNames=N329_12432 {ECO:0000313|EMBL:KFQ07565.1};
OS   Haliaeetus albicilla (White-tailed sea-eagle).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Accipitriformes; Accipitridae;
OC   Accipitrinae; Haliaeetus.
OX   NCBI_TaxID=8969 {ECO:0000313|EMBL:KFQ07565.1};
RN   [1] {ECO:0000313|EMBL:KFQ07565.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BGI_N329 {ECO:0000313|EMBL:KFQ07565.1};
RA   Zhang G., Li C.;
RT   "Genome evolution of avian class.";
RL   Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003822};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003822}.
CC   -!- SIMILARITY: Belongs to the inward rectifier-type potassium channel
CC       (TC 1.A.2.1) family. {ECO:0000256|RuleBase:RU003822}.
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DR   EMBL; KK659991; KFQ07565.1; -; Genomic_DNA.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0015467; F:G-protein activated inward rectifier potassium channel activity; IEA:InterPro.
DR   GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.40.1400; -; 1.
DR   InterPro; IPR014756; Ig_E-set.
DR   InterPro; IPR041647; IRK_C.
DR   InterPro; IPR016449; K_chnl_inward-rec_Kir.
DR   InterPro; IPR003275; K_chnl_inward-rec_Kir3.2.
DR   InterPro; IPR013518; K_chnl_inward-rec_Kir_cyto.
DR   InterPro; IPR040445; Kir_TM.
DR   PANTHER; PTHR11767; PTHR11767; 1.
DR   PANTHER; PTHR11767:SF19; PTHR11767:SF19; 1.
DR   Pfam; PF01007; IRK; 1.
DR   Pfam; PF17655; IRK_C; 1.
DR   PIRSF; PIRSF005465; GIRK_kir; 1.
DR   PRINTS; PR01328; KIR32CHANNEL.
DR   PRINTS; PR01320; KIRCHANNEL.
DR   SUPFAM; SSF81296; SSF81296; 1.
PE   3: Inferred from homology;
KW   Ion channel {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434609, ECO:0000313|EMBL:KFQ07565.1};
KW   Ion transport {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434639};
KW   Membrane {ECO:0000256|SAAS:SAAS00434581, ECO:0000256|SAM:Phobius};
KW   Potassium {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434575};
KW   Potassium transport {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434641};
KW   Transmembrane {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434543, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00036756,
KW   ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00036755};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00048561}.
FT   TRANSMEM     92    115       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    127    146       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    166    190       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       56    195       IRK. {ECO:0000259|Pfam:PF01007}.
FT   DOMAIN      202    372       IRK_C. {ECO:0000259|Pfam:PF17655}.
FT   REGION      389    422       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   COMPBIAS    390    422       Polyampholyte. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   SITE        181    181       Role in the control of polyamine-mediated
FT                                channel gating and in the blocking by
FT                                intracellular magnesium.
FT                                {ECO:0000256|PIRSR:PIRSR005465-1}.
FT   NON_TER       1      1       {ECO:0000313|EMBL:KFQ07565.1}.
FT   NON_TER     422    422       {ECO:0000313|EMBL:KFQ07565.1}.
SQ   SEQUENCE   422 AA;  48426 MW;  95E87B11A74C9682 CRC64;
     VCLFFMAANV LEEDSMEQDI ESPVTIHQPK LPKQAREDLP KNINKECAKR KIQRYVRKDG
     KCNVHHGNVR ETYRYLTDIF TTLVDLKWRF NLLIFVMVYT VTWLFFGMIW WLIAYMRGDM
     DHIGDSTWTP CVSNLNGFVS AFLFSIETET TIGYGYRVIT DKCPEGIILL LVQSVLGSIV
     NAFMVGCMFV KISQPKKRAE TLVFSTNAVI SMRDGKLCLM FRVGDLRNSH IVEASIRAKL
     IKSKQTKEGE FIPLNQTDIN VGYYTGDDRL FLVSPLIISH EINQQSPFWE ISKAQLPKEE
     LEIVVILEGM VEATGMTCQA RSSYITSEIL WGYRFTPVLT LEDGFYEVDY NSFHETYETN
     TPVYSAKELA EMASRAELPL TWSVSSKLDQ HAELETEEEE KNQDDQNERN GDVANLENES
     KV
//
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