ID A0A091PMS8_HALAL Unreviewed; 309 AA.
AC A0A091PMS8;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 22-FEB-2023, entry version 38.
DE SubName: Full=Embryonic pepsinogen {ECO:0000313|EMBL:KFP95951.1};
DE Flags: Fragment;
GN ORFNames=N329_03625 {ECO:0000313|EMBL:KFP95951.1};
OS Haliaeetus albicilla (White-tailed sea-eagle) (Falco albicilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Accipitriformes; Accipitridae;
OC Accipitrinae; Haliaeetus.
OX NCBI_TaxID=8969 {ECO:0000313|EMBL:KFP95951.1, ECO:0000313|Proteomes:UP000054379};
RN [1] {ECO:0000313|EMBL:KFP95951.1, ECO:0000313|Proteomes:UP000054379}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N329 {ECO:0000313|EMBL:KFP95951.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the peptidase A1 family.
CC {ECO:0000256|ARBA:ARBA00007447, ECO:0000256|RuleBase:RU000454}.
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DR EMBL; KK640821; KFP95951.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A091PMS8; -.
DR MEROPS; A01.028; -.
DR Proteomes; UP000054379; Unassembled WGS sequence.
DR GO; GO:0004190; F:aspartic-type endopeptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 2.60.40.1960; -; 1.
DR Gene3D; 2.40.70.10; Acid Proteases; 2.
DR InterPro; IPR001461; Aspartic_peptidase_A1.
DR InterPro; IPR001969; Aspartic_peptidase_AS.
DR InterPro; IPR033121; PEPTIDASE_A1.
DR InterPro; IPR021109; Peptidase_aspartic_dom_sf.
DR PANTHER; PTHR47966; BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED; 1.
DR PANTHER; PTHR47966:SF13; CHYMOSIN; 1.
DR Pfam; PF00026; Asp; 1.
DR PRINTS; PR00792; PEPSIN.
DR SUPFAM; SSF50630; Acid proteases; 1.
DR PROSITE; PS00141; ASP_PROTEASE; 2.
DR PROSITE; PS51767; PEPTIDASE_A1; 1.
PE 3: Inferred from homology;
KW Aspartyl protease {ECO:0000256|RuleBase:RU000454};
KW Disulfide bond {ECO:0000256|PIRSR:PIRSR601461-2};
KW Hydrolase {ECO:0000256|RuleBase:RU000454};
KW Protease {ECO:0000256|RuleBase:RU000454};
KW Reference proteome {ECO:0000313|Proteomes:UP000054379}.
FT DOMAIN 2..306
FT /note="Peptidase A1"
FT /evidence="ECO:0000259|PROSITE:PS51767"
FT ACT_SITE 20
FT /evidence="ECO:0000256|PIRSR:PIRSR601461-1"
FT ACT_SITE 202
FT /evidence="ECO:0000256|PIRSR:PIRSR601461-1"
FT DISULFID 33..38
FT /evidence="ECO:0000256|PIRSR:PIRSR601461-2"
FT DISULFID 193..197
FT /evidence="ECO:0000256|PIRSR:PIRSR601461-2"
FT DISULFID 236..270
FT /evidence="ECO:0000256|PIRSR:PIRSR601461-2"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFP95951.1"
FT NON_TER 309
FT /evidence="ECO:0000313|EMBL:KFP95951.1"
SQ SEQUENCE 309 AA; 33242 MW; 980284A590E186C9 CRC64;
EYYGTISIGT PPQDFTVVFD TGSSNLWVPS ISCTSLACQN HQMFNPSQSS TYKSTGQNLS
IQYGTGNMEG IVGSDTVTVA SLVDTNQLFG LSTTEPGQFF VHVKFDGVLG LGYPNLAADG
ITPVFDNLVN ESLLEENLFS VYLSRETTGS VVIFGGIDES YFTGSINWIF VSYQGYWQIS
MDSIIVNSQE IACSGGCQAI VDTGTSLVAG PPSGISNIQS AVGARQDTYG EYIVNCSSIS
TMPDVIFVID GVQYPVSALA YIEQNDQGPC ISSFQNTSGD LWILGDVFIR VYYSIFDRAN
NRVGLAKAI
//
