ID A0A091PN46_HALAL Unreviewed; 417 AA.
AC A0A091PN46;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=Phosphatidylcholine:ceramide cholinephosphotransferase 1 {ECO:0000256|ARBA:ARBA00039805};
DE EC=2.7.8.27 {ECO:0000256|ARBA:ARBA00038996};
DE AltName: Full=Sphingomyelin synthase 1 {ECO:0000256|ARBA:ARBA00042067};
DE Flags: Fragment;
GN ORFNames=N329_12285 {ECO:0000313|EMBL:KFP96194.1};
OS Haliaeetus albicilla (White-tailed sea-eagle) (Falco albicilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Accipitriformes; Accipitridae;
OC Accipitrinae; Haliaeetus.
OX NCBI_TaxID=8969 {ECO:0000313|EMBL:KFP96194.1, ECO:0000313|Proteomes:UP000054379};
RN [1] {ECO:0000313|EMBL:KFP96194.1, ECO:0000313|Proteomes:UP000054379}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N329 {ECO:0000313|EMBL:KFP96194.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane
CC {ECO:0000256|ARBA:ARBA00004653}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004653}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the sphingomyelin synthase family.
CC {ECO:0000256|ARBA:ARBA00005441}.
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DR EMBL; KK641347; KFP96194.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A091PN46; -.
DR Proteomes; UP000054379; Unassembled WGS sequence.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016780; F:phosphotransferase activity, for other substituted phosphate groups; IEA:InterPro.
DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR GO; GO:0006665; P:sphingolipid metabolic process; IEA:UniProtKB-KW.
DR CDD; cd01610; PAP2_like; 1.
DR CDD; cd09514; SAM_SGMS1; 1.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 1.
DR InterPro; IPR001660; SAM.
DR InterPro; IPR013761; SAM/pointed_sf.
DR InterPro; IPR041418; SAM_3.
DR InterPro; IPR045221; Sphingomyelin_synth-like.
DR InterPro; IPR025749; Sphingomyelin_synth-like_dom.
DR PANTHER; PTHR21290:SF28; PHOSPHATIDYLCHOLINE:CERAMIDE CHOLINEPHOSPHOTRANSFERASE 1; 1.
DR PANTHER; PTHR21290; SPHINGOMYELIN SYNTHETASE; 1.
DR Pfam; PF14360; PAP2_C; 1.
DR Pfam; PF18016; SAM_3; 1.
DR SUPFAM; SSF47769; SAM/Pointed domain; 1.
DR PROSITE; PS50105; SAM_DOMAIN; 1.
PE 3: Inferred from homology;
KW Apoptosis {ECO:0000256|ARBA:ARBA00022703};
KW Golgi apparatus {ECO:0000256|ARBA:ARBA00023034};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000054379};
KW Sphingolipid metabolism {ECO:0000256|ARBA:ARBA00022919};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:KFP96194.1};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 139..160
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 186..207
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 219..237
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 284..300
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 309..329
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 335..351
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 11..74
FT /note="SAM"
FT /evidence="ECO:0000259|PROSITE:PS50105"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFP96194.1"
FT NON_TER 417
FT /evidence="ECO:0000313|EMBL:KFP96194.1"
SQ SEQUENCE 417 AA; 49035 MW; BE5BE2422F7682FC CRC64;
LPGEMKEVVS WSPEEVTNWL TENAVPEYCE PLKSFTGQDL INLTEEDFKK TPLSRVSSDS
GQRLLHMIET LKMAHHIEAH KNGHVNGHIC VSMSNTMREN GFSSKMKLNG MPNGYKKEMI
KIPMPEPERS QYPMEWGKTF LAFIYALFCF IFTTVTISVV HERVPPKEVQ PPLPDAFFDR
FDRVQWAFSI CEINGMILVG LWFIQWLLLK YKSIISRRFF CIVGTLYLYR CITMYVTTLP
VPGMHFKCSP KLFGDWESHL RRIMKLIAGG GLSITGSHNM CGDYLYSGHT VILTLTYLFI
KEYSPRRLWW YHWLCWALSM VGMFCILLAH DHYTVDVVVA YYITTRLFWW YHTMANQQVL
KEASQTNLLA RVWWYKPFQY FEKNVQGIVP RSYHWPFPWP VLHRGRQVKY SRLVNDT
//
