ID A0A091PNI4_HALAL Unreviewed; 720 AA.
AC A0A091PNI4;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 03-MAY-2023, entry version 33.
DE SubName: Full=X-ray repair cross-complementing protein 5 {ECO:0000313|EMBL:KFQ09175.1};
DE Flags: Fragment;
GN ORFNames=N329_02371 {ECO:0000313|EMBL:KFQ09175.1};
OS Haliaeetus albicilla (White-tailed sea-eagle) (Falco albicilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Accipitriformes; Accipitridae;
OC Accipitrinae; Haliaeetus.
OX NCBI_TaxID=8969 {ECO:0000313|EMBL:KFQ09175.1, ECO:0000313|Proteomes:UP000054379};
RN [1] {ECO:0000313|EMBL:KFQ09175.1, ECO:0000313|Proteomes:UP000054379}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N329 {ECO:0000313|EMBL:KFQ09175.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the ku80 family.
CC {ECO:0000256|ARBA:ARBA00007726}.
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DR EMBL; KK662617; KFQ09175.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A091PNI4; -.
DR Proteomes; UP000054379; Unassembled WGS sequence.
DR GO; GO:0043564; C:Ku70:Ku80 complex; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003684; F:damaged DNA binding; IEA:InterPro.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0042162; F:telomeric DNA binding; IEA:InterPro.
DR GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR GO; GO:0006303; P:double-strand break repair via nonhomologous end joining; IEA:InterPro.
DR GO; GO:0000723; P:telomere maintenance; IEA:InterPro.
DR CDD; cd00873; KU80; 1.
DR Gene3D; 1.10.1600.10; -; 1.
DR Gene3D; 2.40.290.10; -; 1.
DR Gene3D; 1.25.40.240; Ku, C-terminal domain; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR006164; Ku70/Ku80_beta-barrel_dom.
DR InterPro; IPR024193; Ku80.
DR InterPro; IPR005160; Ku_C.
DR InterPro; IPR036494; Ku_C_sf.
DR InterPro; IPR005161; Ku_N.
DR InterPro; IPR014893; Ku_PK_bind.
DR InterPro; IPR016194; SPOC-like_C_dom_sf.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR12604; KU AUTOANTIGEN DNA HELICASE; 1.
DR PANTHER; PTHR12604:SF4; X-RAY REPAIR CROSS-COMPLEMENTING PROTEIN 5; 1.
DR Pfam; PF02735; Ku; 1.
DR Pfam; PF03730; Ku_C; 1.
DR Pfam; PF03731; Ku_N; 1.
DR Pfam; PF08785; Ku_PK_bind; 1.
DR PIRSF; PIRSF016570; Ku80; 1.
DR SMART; SM00559; Ku78; 1.
DR SUPFAM; SSF101420; C-terminal domain of Ku80; 1.
DR SUPFAM; SSF100939; SPOC domain-like; 1.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS50234; VWFA; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA recombination {ECO:0000256|ARBA:ARBA00023172};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000054379}.
FT DOMAIN 2..154
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT REGION 540..566
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 681..720
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 681..710
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFQ09175.1"
FT NON_TER 720
FT /evidence="ECO:0000313|EMBL:KFQ09175.1"
SQ SEQUENCE 720 AA; 82035 MW; D1CB712A1D10F1F0 CRC64;
AAIVLCLDVG FTMSSSAPGE ESSLEQAKKI MMKFVQRQVF AESKDEVAVI LFGTDGTRND
LASGDQYQNI TVHRSLMLPD FDLLEDIQDV IKPGSEKADF LDAIIVCMDL LQKETIGKKY
EKRHIELFTD LSSPVSEDQL EIIIANLKKT GISLQIFLPF PMDVDDGGGD VSASVHSHMH
RNSFPKNGLT EQQKEGIDVV RKLMHTLDEE GGLEEIYTFR ESLERLSMFK KIERRPMAWP
CQLTIGSNLS IRIVAYKSVT EEKVKKIWTV VDAKTLRKDD VQKETVYCLN DDDETEVQKD
DTIQGFRYGS DIVPFSKEDE EQMKYKTEGK CFSVLGFSRS SQIQQHYYMG NQVLKVFAAK
DDENAAVAFS ALVHALDELK AVAIVRYAYD RRCNPQIGVA FPYIKDAYEC LIYVQLPYME
DLRQYIFSSL KNNKKCIPTA DQLSAVDSLI DSMNLVYEND DGETFEDLFK PSKIPNPHFQ
RLYQCLQHKA FHPNEPLPPI EQHLLEMLEM PCVVKERCQA PLEKVKALFP LKEVGKKKEE
KTAQDIFKDN EDGPNPKKPK TEDEEGSFSI IKLAEGNVTS VGSVNPAEDF RILVRQKNAD
FKDVSQQLIN RIDQFLENKS SQYYMKGISC IRVFREEAMK LFKVQCFNDF LQALKSKVED
KALADFWEIL IQDRISLITK DETEESSVTS EEAEKFLAPK EKKNETLPPT DEGGDVDDLV
//
