ID A0A091PQ40_HALAL Unreviewed; 1852 AA.
AC A0A091PQ40;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 42.
DE SubName: Full=Fibrillin-2 {ECO:0000313|EMBL:KFQ09451.1};
DE Flags: Fragment;
GN ORFNames=N329_08468 {ECO:0000313|EMBL:KFQ09451.1};
OS Haliaeetus albicilla (White-tailed sea-eagle) (Falco albicilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Accipitriformes; Accipitridae;
OC Accipitrinae; Haliaeetus.
OX NCBI_TaxID=8969 {ECO:0000313|EMBL:KFQ09451.1, ECO:0000313|Proteomes:UP000054379};
RN [1] {ECO:0000313|EMBL:KFQ09451.1, ECO:0000313|Proteomes:UP000054379}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N329 {ECO:0000313|EMBL:KFQ09451.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix {ECO:0000256|ARBA:ARBA00004498}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR EMBL; KK663135; KFQ09451.1; -; Genomic_DNA.
DR Proteomes; UP000054379; Unassembled WGS sequence.
DR GO; GO:0031012; C:extracellular matrix; IEA:UniProt.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR CDD; cd00054; EGF_CA; 20.
DR Gene3D; 2.10.25.10; Laminin; 33.
DR Gene3D; 3.90.290.10; TGF-beta binding (TB) domain; 4.
DR InterPro; IPR026823; cEGF.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR013032; EGF-like_CS.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR024731; EGF_dom.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR017878; TB_dom.
DR InterPro; IPR036773; TB_dom_sf.
DR PANTHER; PTHR47333:SF3; FIBRILLIN 2; 1.
DR PANTHER; PTHR47333; VON WILLEBRAND FACTOR C AND EGF DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF12662; cEGF; 2.
DR Pfam; PF12947; EGF_3; 1.
DR Pfam; PF07645; EGF_CA; 27.
DR Pfam; PF14670; FXa_inhibition; 1.
DR Pfam; PF12661; hEGF; 1.
DR Pfam; PF00683; TB; 4.
DR PIRSF; PIRSF036312; Fibrillin; 1.
DR SMART; SM00181; EGF; 33.
DR SMART; SM00179; EGF_CA; 33.
DR SUPFAM; SSF57196; EGF/Laminin; 7.
DR SUPFAM; SSF57184; Growth factor receptor domain; 9.
DR SUPFAM; SSF57581; TB module/8-cys domain; 4.
DR PROSITE; PS00010; ASX_HYDROXYL; 32.
DR PROSITE; PS01186; EGF_2; 20.
DR PROSITE; PS50026; EGF_3; 30.
DR PROSITE; PS01187; EGF_CA; 13.
DR PROSITE; PS51364; TB; 4.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Extracellular matrix {ECO:0000256|ARBA:ARBA00022530};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Reference proteome {ECO:0000313|Proteomes:UP000054379};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022530};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 5..46
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 47..89
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 90..131
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 132..173
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 217..258
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 259..296
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 301..341
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 342..382
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 383..424
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 425..461
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 466..506
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 511..567
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 584..625
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 626..667
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 672..725
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 742..783
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 784..825
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 826..863
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 868..903
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 907..949
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 950..989
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 990..1031
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1036..1089
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 1105..1146
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1147..1186
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1228..1271
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1272..1313
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1318..1371
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 1383..1420
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1425..1465
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1466..1502
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1505..1547
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1588..1624
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1629..1668
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DISULFID 872..882
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFQ09451.1"
FT NON_TER 1852
FT /evidence="ECO:0000313|EMBL:KFQ09451.1"
SQ SEQUENCE 1852 AA; 202711 MW; ED917BDE81F3D1DC CRC64;
FYFTDINECK VFPGMCMNGK CRNTIGSFKC RCNSGFTLDM EERNCTDIDE CRISPDLCGS
GTCVNTPGSF ECECFDGYES GFMMMKNCMD VDECERNPLL CRGGTCVNTE GSFQCDCPLG
HELSPSREEC IDVNECSLSD SLCRNGKCVN MLGTYQCSCN SGYQATPDRQ GCIGKYIDEC
MIVNGGCDTH CTNSEGSYEC SCSDGYALMP DVRTCADIDE CENSPDICDG GQCTNIPGEY
RCLCFDGFMA SMDMKTCIDV NECDLNSNIC MFGECENTKG SFICHCQLGY SVKKGTTGCT
DVDECEIGAH NCDMHASCVN VPGSFKCSCR EGWVGNGIKC IDLDECSNGT HQCSVNAQCV
NTPGSYRCAC AEGFTGDGFT CSDVDECAEN VNLCENGQCL NIPGAYRCEC EMGFTPASDS
KSCQDIDECS FQNICVFGTC NNLPGMFHCI CDDGYELDRT GGNCTDIDEC ADPINCVNGL
CVNTPGRYEC NCPPDFQLNP TGVGCVDNRV GNCYLKYGPR GDGSLSCNTE IGVGVSRSSC
CCSLGKAWGN PCETCPPVNS TEYNTLCPGG EGFRPNPITI ILEDIDECQE LPGLCQGGNC
INTFGSFQCE CPKGYYLSEE TRICEDIDEC VAHPGVCGPG TCYNTLGNYT CICPPEYMQV
NGGHNCMDMR KSFCYRSYNG TSCENELPFN VTKRMCCCTY NVGKAWNKPC EPCPTPGTAE
FKNICGNIPG FTFDIHTGKA VDIDECKEIP GICANGVCIN QIGSFRCECP TGFSYNDLLL
VCEDIDECSN GDNLCQRNAD CINSPGSYRC ECAAGFKLSP NGACVDRNEC LEIPNVCSHG
LCVDMQGSYQ CICHNGFKAS QDQTMCMDVD ECERHPCGNG TCKNTVGSYN CLCYPGFELT
HNNDCMDIDE CSSFFGQVCR NGRCFNEIGS FKCLCNEGYE LTVDGKNCID TNECVALPGS
CSPGTCQNLE GSFRCICPPG YEVKSESCID INECNEDPNI CLFGSCTNTA GGFQCICPTG
FVLSDNGRRC FDTRQSFCFT NFENGKCSVP KAFNTTKAKC CCSKMPGEGW GDPCELCPKE
EEVAFQDLCP YGHGTIPGID DTREDVNECL ESPGICSNGH CINTDGSFRC ECPMGYNLDY
TGVHCIDTDE CSIGNPCGNG TCTNMIGSFE CNCHEGFEPG PMMNCEDINE CAQNPLLCAF
RCINTYGFYE CTCPVGYELR EDQKMCKDLD ECAEGLHDCE SRGMMCKNLI GTFMCICPPG
MTRRPDGEGC TDENECRTKP GICENGRCVN VIGSYRCECN EGFLSSPSRI ECLDNRQGFC
FAEVLQTMCQ MSSSSRNLVT KSECCCDGGR GWGNQCELCP LPGTTQYKKL CPHGPGYTTD
GRDIDECKVM PKLCRNGQCI NTMGSFRCFC KVGYTTDISG TSCIDLDECS QSPKPCNFIC
KNSEGSYQCS CPRGYILQED GKTCRDLDEC QSKQHNCQFL CVNTLGGFTC KCPPGFTQHH
TACIDNNECG SQPSLCGSKG ICQNTPGSFT CECQRGFSLD STGLNCEDVD ECDGNHRCQH
GCQNILGGYR CGCPQGYIQH YQWNQCVDEN ECSNPNTCGS ASCYNTLGSY KCACPSGFSY
DQFSSACHDV NECSSTKNPC NYGCSNTEGG YLCGCPPGYY RVGQGHCVSG MGFNKGQYLP
LDGDADEENA LSPEACYECK INGYSKKDNR KKRSTNDTVC TRINKHYSIE QISLESLDMD
SPLKMRVNIS RLDNKEHILE LMPAIEPLTN HVRYIISRGN DDGIFQIHER DGLSYLHTVK
KKSVPGTHTL EITSIPLYRK KELKKLEDSN EDNYLLGELG EALRMRLWID LY
//
