ID   A0A091PQM2_HALAL        Unreviewed;       739 AA.
AC   A0A091PQM2;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   27-MAR-2024, entry version 32.
DE   SubName: Full=MFN1 protein {ECO:0000313|EMBL:NWZ49829.1};
DE   SubName: Full=Mitofusin-1 {ECO:0000313|EMBL:KFQ09980.1};
GN   Name=Mfn1 {ECO:0000313|EMBL:NWZ49829.1};
GN   ORFNames=HALALB_R11660 {ECO:0000313|EMBL:NWZ49829.1}, N329_10463
GN   {ECO:0000313|EMBL:KFQ09980.1};
OS   Haliaeetus albicilla (White-tailed sea-eagle) (Falco albicilla).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Accipitriformes; Accipitridae;
OC   Accipitrinae; Haliaeetus.
OX   NCBI_TaxID=8969 {ECO:0000313|EMBL:KFQ09980.1, ECO:0000313|Proteomes:UP000054379};
RN   [1] {ECO:0000313|EMBL:KFQ09980.1, ECO:0000313|Proteomes:UP000054379}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BGI_N329 {ECO:0000313|EMBL:KFQ09980.1};
RA   Zhang G., Li C.;
RT   "Genome evolution of avian class.";
RL   Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:NWZ49829.1, ECO:0000313|Proteomes:UP000585422}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=OUT-0040 {ECO:0000313|EMBL:NWZ49829.1};
RC   TISSUE=Blood {ECO:0000313|EMBL:NWZ49829.1};
RA   Zhang G.;
RT   "Bird 10,000 Genomes (B10K) Project - Family phase.";
RL   Submitted (SEP-2019) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. Mitochondrion
CC       outer membrane {ECO:0000256|ARBA:ARBA00004374}; Multi-pass membrane
CC       protein {ECO:0000256|ARBA:ARBA00004374}.
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DR   EMBL; KK663941; KFQ09980.1; -; Genomic_DNA.
DR   EMBL; VZSQ01000043; NWZ49829.1; -; Genomic_DNA.
DR   Proteomes; UP000054379; Unassembled WGS sequence.
DR   Proteomes; UP000585422; Unassembled WGS sequence.
DR   GO; GO:0005741; C:mitochondrial outer membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR   GO; GO:0008053; P:mitochondrial fusion; IEA:InterPro.
DR   CDD; cd09912; DLP_2; 1.
DR   Gene3D; 1.20.5.110; -; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   InterPro; IPR045063; Dynamin_N.
DR   InterPro; IPR006884; Fzo/mitofusin_HR2.
DR   InterPro; IPR030381; G_DYNAMIN_dom.
DR   InterPro; IPR027094; Mitofusin_fam.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR10465:SF2; MITOFUSIN-1; 1.
DR   PANTHER; PTHR10465; TRANSMEMBRANE GTPASE FZO1; 1.
DR   Pfam; PF00350; Dynamin_N; 1.
DR   Pfam; PF04799; Fzo_mitofusin; 1.
DR   SUPFAM; SSF111479; Fzo-like conserved region; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS51718; G_DYNAMIN_2; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Membrane {ECO:0000256|ARBA:ARBA00022989};
KW   Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW   Mitochondrion outer membrane {ECO:0000256|ARBA:ARBA00022787};
KW   Reference proteome {ECO:0000313|Proteomes:UP000054379};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT   DOMAIN          73..322
FT                   /note="Dynamin-type G"
FT                   /evidence="ECO:0000259|PROSITE:PS51718"
FT   COILED          374..405
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          682..733
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   739 AA;  84039 MW;  8EB0EA386F0DD0E1 CRC64;
     MAEATVSPLK HFVLAKKTIT AIFDQLLDYV SEGATFVEAT YKNPELERVA TEDELQKIQA
     YKNKLAVIGE VLSRRHMKVA FFGRTSSGKS SVINAMLWDK VLPSGIGHTT NCFLSVEGTD
     GDKAYLMTEG SDEKKSVKTV NQLAHALHMD KDLKAGCLVH VFWPKSKCAL LRDDLVLVDS
     PGTDVTTELD SWIDKFCLDA DVFVLVANSE STLMNTEKHF FHKVNERLSK PNIFILNNRW
     DASASEPEYM EDVRRQHMER CLTFLVDELK VIDPVEARNR IFFVSAKEVL SARRQKAQGM
     PEGGGALAEG FQTRFQEFQH FEQIFEECIS QSAVKTKFEQ HTIRAKQIID TVKNIMDAIN
     VAAAEKRVHS MEEREDQKDR LDFVRNQLNI LTEDTKEKIK RVTEEVENKV SSAMTDEICR
     LSLLVDEFYS DFHPSPQVLK LYKTELNKHI EDGLGKNLAD RCSSEVNQSM HQSQQEMIEN
     LKPLLPSGAQ SQLHLLIPCR KFDLSYDLNC HSLCADFQED IMFHFSLGWT SLVNRFLGPK
     QAQRVLLGLA DPNLQIPRPL ATTPSAASLP AVTPENVSHD DFMVPLVMSL ASLTSRTSMS
     IIVVGGIWRT VGWKLISVSL SMYGLLYLYE RLTWTTKAKE RAFKQQFVNY ATEKLQMIVS
     LTSANCSHQV QQEMATTFAR LCQQVDITQK NLEKEIARLS KEIDQLENIQ SNSKQLRNKA
     IHLENELDRF TKHFLQKSK
//