ID   A0A091PSX8_LEPDC        Unreviewed;       614 AA.
AC   A0A091PSX8;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   27-MAR-2024, entry version 37.
DE   SubName: Full=Amiloride-sensitive sodium channel subunit gamma {ECO:0000313|EMBL:KFQ10436.1};
DE   Flags: Fragment;
GN   ORFNames=N330_09762 {ECO:0000313|EMBL:KFQ10436.1};
OS   Leptosomus discolor (Madagascar cuckoo roller) (Cuculus discolor).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Coraciiformes; Leptosomidae; Leptosomus.
OX   NCBI_TaxID=188344 {ECO:0000313|EMBL:KFQ10436.1, ECO:0000313|Proteomes:UP000053001};
RN   [1] {ECO:0000313|EMBL:KFQ10436.1, ECO:0000313|Proteomes:UP000053001}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BGI_N330 {ECO:0000313|EMBL:KFQ10436.1};
RA   Zhang G., Li C.;
RT   "Genome evolution of avian class.";
RL   Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Apical cell membrane
CC       {ECO:0000256|ARBA:ARBA00004424}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004424}. Cell membrane
CC       {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the amiloride-sensitive sodium channel (TC
CC       1.A.6) family. SCNN1G subfamily. {ECO:0000256|ARBA:ARBA00038067}.
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DR   EMBL; KK677917; KFQ10436.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A091PSX8; -.
DR   PhylomeDB; A0A091PSX8; -.
DR   Proteomes; UP000053001; Unassembled WGS sequence.
DR   GO; GO:0016324; C:apical plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015280; F:ligand-gated sodium channel activity; IEA:InterPro.
DR   Gene3D; 2.60.470.10; Acid-sensing ion channels like domains; 1.
DR   Gene3D; 1.10.287.770; YojJ-like; 1.
DR   InterPro; IPR001873; ENaC.
DR   InterPro; IPR004724; ENaC_chordates.
DR   InterPro; IPR020903; ENaC_CS.
DR   NCBIfam; TIGR00859; ENaC; 1.
DR   PANTHER; PTHR11690:SF19; AMILORIDE-SENSITIVE SODIUM CHANNEL SUBUNIT GAMMA; 1.
DR   PANTHER; PTHR11690; AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED; 1.
DR   Pfam; PF00858; ASC; 1.
DR   PRINTS; PR01078; AMINACHANNEL.
DR   PROSITE; PS01206; ASC; 1.
PE   3: Inferred from homology;
KW   Ion channel {ECO:0000313|EMBL:KFQ10436.1};
KW   Ion transport {ECO:0000256|ARBA:ARBA00022461};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000053001};
KW   Sodium {ECO:0000256|ARBA:ARBA00023053};
KW   Sodium channel {ECO:0000256|ARBA:ARBA00022461};
KW   Sodium transport {ECO:0000256|ARBA:ARBA00023201};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022461}.
FT   TRANSMEM        20..43
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   REGION          536..595
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        536..561
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:KFQ10436.1"
FT   NON_TER         614
FT                   /evidence="ECO:0000313|EMBL:KFQ10436.1"
SQ   SEQUENCE   614 AA;  69935 MW;  76D92187C070388A CRC64;
     NTHGCRRIVV SRGRLRRFLW ILLTLSAVGL ILWQCAELLM NYYSASVSVT VQFQKLPFPA
     VTICNINPYK YSSMKDYLSE LDKETKKALE TFYGFSEGKS KVRRSVEEWN STASDFFTQI
     PLLKFEDLYK TATDLRSGQK RKIEGSVFHK DSSIVNSGDS NIIGFQLCDA NNSSECALYT
     FSSGVNAIQE WYKLHYMNIM AQIPLETKEK LSYSADDLLL TCFFDGLSCD KRHFTRFHHP
     LHGNCYTFNS GENGTILSTS TGGSEYGLQV VLYIDEADYN PFLVTSTGAK IIVHDQNEYP
     FIEDIGTEIE TAAATSIGMH FTRSRKLSKP YSDCTETGAD IPVENLYNKS YSLQICLHSC
     FQKAMVDSCG CAQYAQPLPA GAEYCNYKKN PNWMYCYYRL HEKFVKEQLG CQQICKDACS
     FKEWALTTSI AQWPSAVSED WMLRVLSWDK GQKINKKLNK TDLANLMVFY KDLNERFISE
     NPANTLVILL SNFGGQLGLW MSCSVVCVIE IVEVFFIDSL SIVMRRQWQK AKKWWNDRQR
     DRSGKAPQGG DPERQGHDNP VCPDEDLPTF NTALRLPLPQ DNPLPRTPPP NYSTLRLETA
     FTEQLPDTLE VGQH
//