ID A0A091PTL8_HALAL Unreviewed; 1551 AA.
AC A0A091PTL8;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE RecName: Full=Voltage-dependent L-type calcium channel subunit alpha {ECO:0000256|RuleBase:RU003808};
DE Flags: Fragment;
GN ORFNames=N329_13231 {ECO:0000313|EMBL:KFQ11000.1};
OS Haliaeetus albicilla (White-tailed sea-eagle) (Falco albicilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Accipitriformes; Accipitridae;
OC Accipitrinae; Haliaeetus.
OX NCBI_TaxID=8969 {ECO:0000313|EMBL:KFQ11000.1, ECO:0000313|Proteomes:UP000054379};
RN [1] {ECO:0000313|EMBL:KFQ11000.1, ECO:0000313|Proteomes:UP000054379}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N329 {ECO:0000313|EMBL:KFQ11000.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the entry
CC of calcium ions into excitable cells and are also involved in a variety
CC of calcium-dependent processes, including muscle contraction, hormone
CC or neurotransmitter release, gene expression, cell motility, cell
CC division and cell death. {ECO:0000256|RuleBase:RU003808}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003808}; Multi-
CC pass membrane protein {ECO:0000256|RuleBase:RU003808}.
CC -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit (TC
CC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
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DR EMBL; KK665431; KFQ11000.1; -; Genomic_DNA.
DR Proteomes; UP000054379; Unassembled WGS sequence.
DR GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 4.
DR Gene3D; 6.10.250.2180; -; 1.
DR Gene3D; 6.10.250.2500; -; 1.
DR Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 4.
DR InterPro; IPR031649; GPHH_dom.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR014873; VDCC_a1su_IQ.
DR InterPro; IPR005450; VDCC_L_a1ssu.
DR InterPro; IPR005446; VDCC_L_a1su.
DR InterPro; IPR002077; VDCCAlpha1.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR PANTHER; PTHR45628; VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1; 1.
DR PANTHER; PTHR45628:SF9; VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S; 1.
DR Pfam; PF08763; Ca_chan_IQ; 1.
DR Pfam; PF16905; GPHH; 1.
DR Pfam; PF00520; Ion_trans; 4.
DR PRINTS; PR00167; CACHANNEL.
DR PRINTS; PR01630; LVDCCALPHA1.
DR PRINTS; PR01634; LVDCCALPHA1S.
DR SMART; SM01062; Ca_chan_IQ; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 4.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PIRSR:PIRSR602077-1};
KW Calcium channel {ECO:0000256|ARBA:ARBA00022673,
KW ECO:0000256|RuleBase:RU003808};
KW Calcium transport {ECO:0000256|ARBA:ARBA00022568,
KW ECO:0000256|RuleBase:RU003808};
KW Glycoprotein {ECO:0000256|PIRSR:PIRSR602077-3};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|PIRSR:PIRSR602077-1};
KW Reference proteome {ECO:0000313|Proteomes:UP000054379};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448};
KW Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882,
KW ECO:0000256|RuleBase:RU003808}.
FT TRANSMEM 5..22
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 42..62
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 139..160
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 258..280
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 402..419
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 439..456
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 528..550
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 604..630
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 764..783
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 795..817
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 837..860
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 881..914
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1005..1032
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1073..1092
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1118..1138
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1213..1231
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1305..1328
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1462..1495
FT /note="Voltage-dependent calcium channel alpha-1 subunit
FT IQ"
FT /evidence="ECO:0000259|SMART:SM01062"
FT REGION 695..719
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 239
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR602077-1"
FT BINDING 583
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR602077-1"
FT BINDING 978
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR602077-1"
FT CARBOHYD 204
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000256|PIRSR:PIRSR602077-3"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFQ11000.1"
FT NON_TER 1551
FT /evidence="ECO:0000313|EMBL:KFQ11000.1"
SQ SEQUENCE 1551 AA; 177582 MW; 5A2F6D302BC4BF15 CRC64;
RPFEIIILLT IFANCVALAV YLPMPEDDTN VANSSLEKIE YAFLIFFAIE AMLKIIAYGF
LFHTDAYLRN GWNVLDFSIV SLGLITMTLE QVNAKQGGTS GGKGGFDVKA LRAFRVLRPL
RLVSGVPSLQ VVLNSIIKAM VPLLHIALLV LFMIIIYAIV GQELFKGKMH KTCYYLGTDV
IATVASEKPA PCTSSGHGRH CTINGTECRS GWPGPNNGIT HFDNFGFAML TVYQCITMEG
WTEVLYWVND AIGNEWPWIY FVSLILLGSF FVLNLVLGVL SGEFTKEREK AKSRGTFQKL
REKQQLEEDL KGYMDWITHA EVMDSDRARG EGSSSAWSKT LSMRVGFLTL TILERQGRDS
LPHVLPKGSS ESLGCRSLLS RRWRRWNRMF RRKCRDVVKS KFFYWLVILL VALNTLSIAS
EHHFQPEWLT QVQDNANRVL LALFVAEMLL KMYALGLRQY FMSLFNRFDC FVVCAGILET
ILVELGTLSP LGISVLRCIR LLRIFKITRY WTSLSNLVAS LLNSVRSIAS LLLLLFLFII
VFALLGMQLF GGKFDFEDME VRRSTFDNFP QALISVFQIL TGEDWNSIMY DGIMAYGGPS
FPGMLVCIYF IILFVCGNYI LLNVFLAIAV DNLAEAESLT LAQKAKAEER KRRKMSRVWP
TCSIWQQYWH TQLHVLSVSP LFQLKVDEFE SNVNEIKDPY PSADFPGDDE EDEPEIPLSP
RPRPLAELQL KEKAVPMPEA SSFFIFSPTN KFRMLCHRIV NATWFTNFIL LFILLSSISL
AAEDPIRAES FRNQILGYFD IGFTSVFTVE IVLKMTAYGA FLHKGSFCRN SFNILDLLVV
AVSLISMGIE SSAISVVKIL RVLRALRALR AINRAKGLKH VVQCVFVAIK TIGNIVVVTT
LLQFMFACIG VQLFKGKFYR CTDPSKMTEK ECRGYFINYV DGDPTQIELQ ERVWLHSNFH
FDNVFSAMMS LFTVSTFEGW PELLYMAIDT NAEDTGPVYN YRVEIAMFFI IYIILIAFFM
MNIFVGFVIV TFQEQGESEY KNCELDKNQR QCVQYALKAR PLRRYIPKNP YQYQIWYVVT
SSYFEYLIVW TYRGLTWLLL PSPQHYNQSA EMNHISDILN VAFTILFTLE MILKLMAFKA
KGYFGDPWNV FDFLIVIGSI IDVILSEIDD SDDNSRVSIT FFRLFRVMRL VKLLSRGEGV
RTLLWTFIKS FQALPYVALL IVMLFFIYAV IGMQMFGKIA MVDGTQINRN NNFQTFPQAV
LLLFRCATGE AWQEILLDCS YGKLCDPESD FAEGEEYTCG TGFAYFYFIS FYMLCAFLII
NLFVAVIMDN FDYLTRDWSI LGPHHLDEFK RIWAEYDPEA KGRIKHLDVV TLLRRIQPPL
GFGKFCPHRV ACKRLVCMNM PLNSDGTVTF NATLFALVRT ALKIKTEGNF EQANEELRAI
IKKIWKRTSM KLLDQVIPPI GDDEVTVGKF YATFLIQEHF RKFMKRQEEY YGYRPKKNPV
EIQAGLRSIE EEAAPEIHRA ISGDLTAEEE LERAMVEAAM EEGIYRVSAA L
//
