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Database: UniProt
Entry: A0A091PUF6_LEPDC
LinkDB: A0A091PUF6_LEPDC
Original site: A0A091PUF6_LEPDC 
ID   A0A091PUF6_LEPDC        Unreviewed;       121 AA.
AC   A0A091PUF6;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   22-FEB-2023, entry version 16.
DE   RecName: Full=6-pyruvoyl tetrahydrobiopterin synthase {ECO:0000256|ARBA:ARBA00015587};
DE            EC=4.2.3.12 {ECO:0000256|ARBA:ARBA00013100};
DE   Flags: Fragment;
GN   ORFNames=N330_11054 {ECO:0000313|EMBL:KFQ10976.1};
OS   Leptosomus discolor (Madagascar cuckoo roller) (Cuculus discolor).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Coraciiformes; Leptosomidae; Leptosomus.
OX   NCBI_TaxID=188344 {ECO:0000313|EMBL:KFQ10976.1, ECO:0000313|Proteomes:UP000053001};
RN   [1] {ECO:0000313|EMBL:KFQ10976.1, ECO:0000313|Proteomes:UP000053001}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BGI_N330 {ECO:0000313|EMBL:KFQ10976.1};
RA   Zhang G., Li C.;
RT   "Genome evolution of avian class.";
RL   Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in the biosynthesis of tetrahydrobiopterin, an
CC       essential cofactor of aromatic amino acid hydroxylases. Catalyzes the
CC       transformation of 7,8-dihydroneopterin triphosphate into 6-pyruvoyl
CC       tetrahydropterin. {ECO:0000256|ARBA:ARBA00025266}.
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|ARBA:ARBA00001947};
CC   -!- PATHWAY: Cofactor biosynthesis; tetrahydrobiopterin biosynthesis;
CC       tetrahydrobiopterin from 7,8-dihydroneopterin triphosphate: step 1/3.
CC       {ECO:0000256|ARBA:ARBA00005126}.
CC   -!- SIMILARITY: Belongs to the PTPS family.
CC       {ECO:0000256|ARBA:ARBA00009164}.
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DR   EMBL; KK678584; KFQ10976.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A091PUF6; -.
DR   PhylomeDB; A0A091PUF6; -.
DR   UniPathway; UPA00849; UER00819.
DR   Proteomes; UP000053001; Unassembled WGS sequence.
DR   GO; GO:0003874; F:6-pyruvoyltetrahydropterin synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006729; P:tetrahydrobiopterin biosynthetic process; IEA:UniProtKB-UniPathway.
DR   CDD; cd00470; PTPS; 1.
DR   Gene3D; 3.30.479.10; 6-pyruvoyl tetrahydropterin synthase/QueD; 1.
DR   InterPro; IPR007115; 6-PTP_synth/QueD.
DR   InterPro; IPR038418; 6-PTP_synth/QueD_sf.
DR   InterPro; IPR022470; PTPS_Cys_AS.
DR   InterPro; IPR022469; PTPS_His_AS.
DR   PANTHER; PTHR12589:SF7; 6-PYRUVOYL TETRAHYDROBIOPTERIN SYNTHASE; 1.
DR   PANTHER; PTHR12589; PYRUVOYL TETRAHYDROBIOPTERIN SYNTHASE; 1.
DR   Pfam; PF01242; PTPS; 1.
DR   SUPFAM; SSF55620; Tetrahydrobiopterin biosynthesis enzymes-like; 1.
DR   PROSITE; PS00987; PTPS_1; 1.
DR   PROSITE; PS00988; PTPS_2; 1.
PE   3: Inferred from homology;
KW   Lyase {ECO:0000256|ARBA:ARBA00023239};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Reference proteome {ECO:0000313|Proteomes:UP000053001};
KW   Tetrahydrobiopterin biosynthesis {ECO:0000256|ARBA:ARBA00023007};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:KFQ10976.1"
FT   NON_TER         121
FT                   /evidence="ECO:0000313|EMBL:KFQ10976.1"
SQ   SEQUENCE   121 AA;  13777 MW;  6C23C49D0D2892FF CRC64;
     SKSLSDEENL KLFGKCNNPN GHGHNYKVIV TVRGEIDPVS GMVINLTDLK EYMQEAIMEP
     LDHKNLDKDV PYFAEVVSTT ENVAVFIWEN LKKLLPMGTL YKVKVYETDQ NIVVYKGEET
     I
//
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