ID A0A091PV68_HALAL Unreviewed; 259 AA.
AC A0A091PV68;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE SubName: Full=CLD18 protein {ECO:0000313|EMBL:NWZ54906.1};
DE SubName: Full=Claudin-18 {ECO:0000313|EMBL:KFQ00705.1};
GN Name=Cldn18 {ECO:0000313|EMBL:NWZ54906.1};
GN ORFNames=HALALB_R11407 {ECO:0000313|EMBL:NWZ54906.1}, N329_04319
GN {ECO:0000313|EMBL:KFQ00705.1};
OS Haliaeetus albicilla (White-tailed sea-eagle) (Falco albicilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Accipitriformes; Accipitridae;
OC Accipitrinae; Haliaeetus.
OX NCBI_TaxID=8969 {ECO:0000313|EMBL:KFQ00705.1, ECO:0000313|Proteomes:UP000054379};
RN [1] {ECO:0000313|EMBL:KFQ00705.1, ECO:0000313|Proteomes:UP000054379}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N329 {ECO:0000313|EMBL:KFQ00705.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:NWZ54906.1, ECO:0000313|Proteomes:UP000585422}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=OUT-0040 {ECO:0000313|EMBL:NWZ54906.1};
RC TISSUE=Blood {ECO:0000313|EMBL:NWZ54906.1};
RA Zhang G.;
RT "Bird 10,000 Genomes (B10K) Project - Family phase.";
RL Submitted (SEP-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell junction, tight junction
CC {ECO:0000256|ARBA:ARBA00004435}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the claudin family.
CC {ECO:0000256|ARBA:ARBA00008295}.
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DR EMBL; KK649009; KFQ00705.1; -; Genomic_DNA.
DR EMBL; VZSQ01000133; NWZ54906.1; -; Genomic_DNA.
DR RefSeq; XP_009912957.1; XM_009914655.1.
DR GeneID; 104314943; -.
DR KEGG; hald:104314943; -.
DR CTD; 51208; -.
DR OrthoDB; 5346296at2759; -.
DR Proteomes; UP000054379; Unassembled WGS sequence.
DR Proteomes; UP000585422; Unassembled WGS sequence.
DR GO; GO:0005923; C:bicellular tight junction; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR Gene3D; 1.20.140.150; -; 1.
DR InterPro; IPR006187; Claudin.
DR InterPro; IPR003928; Claudin18.
DR InterPro; IPR017974; Claudin_CS.
DR InterPro; IPR004031; PMP22/EMP/MP20/Claudin.
DR PANTHER; PTHR12002; CLAUDIN; 1.
DR PANTHER; PTHR12002:SF9; CLAUDIN-18; 1.
DR Pfam; PF00822; PMP22_Claudin; 1.
DR PRINTS; PR01077; CLAUDIN.
DR PRINTS; PR01448; CLAUDIN18.
DR PROSITE; PS01346; CLAUDIN; 1.
PE 3: Inferred from homology;
KW Cell junction {ECO:0000256|ARBA:ARBA00022949};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000054379};
KW Tight junction {ECO:0000256|ARBA:ARBA00022427};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 7..27
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 81..101
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 122..149
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 169..196
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 219..259
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 233..259
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 259 AA; 28293 MW; D4589413E96E07AE CRC64;
MSTTICQVMA FIVSSLGVAG CIVSTAMDMW STQDLYDNPV TAVFQYQGLW RSCVRQSSGF
TECRPYFTIL GLPAMFQAVR ALMIVGIVLG ILGLLVCIFA LKCIRIGNME DSAKANMTLT
SGIMFIVAGL CAITGVSVFA NMLVTNFWMS TANMYQGMQN VQNRYTFGSA LFVGWVAGGL
ALVGGIMMCL ACRGLIPEES RYKAVSYNAS GRNISYRTGP YKVGSGYEPE TKTRKNAGYE
EAARSEDGRR SYPSKYDYV
//
