ID A0A091Q199_LEPDC Unreviewed; 764 AA.
AC A0A091Q199;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 2 {ECO:0000256|ARBA:ARBA00021134};
DE EC=2.1.1.296 {ECO:0000256|ARBA:ARBA00012770};
GN ORFNames=N330_08144 {ECO:0000313|EMBL:KFQ13301.1};
OS Leptosomus discolor (Madagascar cuckoo roller) (Cuculus discolor).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Coraciiformes; Leptosomidae; Leptosomus.
OX NCBI_TaxID=188344 {ECO:0000313|EMBL:KFQ13301.1, ECO:0000313|Proteomes:UP000053001};
RN [1] {ECO:0000313|EMBL:KFQ13301.1, ECO:0000313|Proteomes:UP000053001}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N330 {ECO:0000313|EMBL:KFQ13301.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-
CC ribonucleoside)-(ribonucleotide) in mRNA + S-adenosyl-L-methionine =
CC a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-
CC ribonucleoside)-(2'-O-methyl-ribonucleotide) in mRNA + H(+) + S-
CC adenosyl-L-homocysteine; Xref=Rhea:RHEA:67024, Rhea:RHEA-COMP:17169,
CC Rhea:RHEA-COMP:17170, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856,
CC ChEBI:CHEBI:59789, ChEBI:CHEBI:167612, ChEBI:CHEBI:167614;
CC EC=2.1.1.296; Evidence={ECO:0000256|ARBA:ARBA00024560};
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DR EMBL; KK682788; KFQ13301.1; -; Genomic_DNA.
DR RefSeq; XP_009952254.1; XM_009953952.1.
DR AlphaFoldDB; A0A091Q199; -.
DR GeneID; 104348619; -.
DR KEGG; ldi:104348619; -.
DR CTD; 55783; -.
DR OrthoDB; 5488054at2759; -.
DR PhylomeDB; A0A091Q199; -.
DR Proteomes; UP000053001; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProt.
DR GO; GO:0004483; F:mRNA (nucleoside-2'-O-)-methyltransferase activity; IEA:UniProt.
DR Gene3D; 3.40.50.12760; -; 2.
DR InterPro; IPR025807; Adrift-typ_MeTrfase.
DR InterPro; IPR002877; RNA_MeTrfase_FtsJ_dom.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR16121:SF2; CAP-SPECIFIC MRNA (NUCLEOSIDE-2'-O-)-METHYLTRANSFERASE 2; 1.
DR PANTHER; PTHR16121; UNCHARACTERIZED; 1.
DR Pfam; PF01728; FtsJ; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS51614; SAM_MT_ADRIFT; 1.
PE 4: Predicted;
KW Methyltransferase {ECO:0000256|PROSITE-ProRule:PRU00946,
KW ECO:0000313|EMBL:KFQ13301.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000053001};
KW S-adenosyl-L-methionine {ECO:0000256|PROSITE-ProRule:PRU00946};
KW Transferase {ECO:0000256|PROSITE-ProRule:PRU00946,
KW ECO:0000313|EMBL:KFQ13301.1}.
FT DOMAIN 109..322
FT /note="Adrift-type SAM-dependent 2'-O-MTase"
FT /evidence="ECO:0000259|PROSITE:PS51614"
FT ACT_SITE 275
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00946"
FT BINDING 148
FT /ligand="S-adenosyl-L-methionine"
FT /ligand_id="ChEBI:CHEBI:59789"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00946"
FT BINDING 167
FT /ligand="S-adenosyl-L-methionine"
FT /ligand_id="ChEBI:CHEBI:59789"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00946"
FT BINDING 235
FT /ligand="S-adenosyl-L-methionine"
FT /ligand_id="ChEBI:CHEBI:59789"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00946"
SQ SEQUENCE 764 AA; 87262 MW; E01992C3FE4018FA CRC64;
MNKCKKPFVD QTTTLEKFSP EIVSEIEKLF VKKFTYTKPV NNEWQLPDPS DAFTCDHKEF
DSLLALKDSM NEVKNQLSDK NLNEWHQHTS FTNKAGKIIP HVKKSVNAEL CTQAWCKFHE
ILCSFPLLPE EALQDGELNS VHLCEAPGAF IASLNHYLKS HHVPCDWNWV ANTLNPYHEA
NDTLMMIMDD RLIANTLPWW YFGPDNTGDV MTLKHLTGLQ NFVSNMATVH LVTADGSFDC
QGNPGEQEAL VSPLHYCETV TALMILGTGG SFVLKMFTLF EHCSTNLLFL LNCSFEEVHV
FKPATSKAGN SEAYVICLRY MGRESIHLLL SKMIQNFGTE MVNKALFPQH MLPESFLKVH
EKCCIFFHKC QVETISENIH LFERMEEAEQ AKLNKLRDCA VELFMQRLHM KPIARNNWLV
KKSQTGCSMN AKWFGQRNKY FSTYNERKMM ETLTWNDKVA KGYLNHWAEE HSFNNVGKMC
ILEGSSSNLE CSLWYILEGK RLPMVKCSPF CDGQVLENLN EAMNEVVGRK LKSRQMLQTC
HLCEVLPGEL MLAEVSDLSR CHQELLNERC SDQFRCLVVD LPSLCGTESQ LSMEIKLLDS
ATLLTFSFSL LYDGEPKYQQ QLLECVLHSL NQLTMGDALI LPILSCFTRF TAGLIFVLHC
CFRYITFACP TSHEPLKTSA ALLCVGYRGL PNPVVEYLQH LNKLMSSLLD TESPQQVLQF
VPMEVLLQGK LLEFLWDLNT AIAKRQLHLI VQAKQQQMTS NVSL
//
