ID A0A091Q2Z6_LEPDC Unreviewed; 1812 AA.
AC A0A091Q2Z6;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE SubName: Full=Histone-lysine N-methyltransferase SETD2 {ECO:0000313|EMBL:KFQ04039.1};
DE Flags: Fragment;
GN ORFNames=N330_11848 {ECO:0000313|EMBL:KFQ04039.1};
OS Leptosomus discolor (Madagascar cuckoo roller) (Cuculus discolor).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Coraciiformes; Leptosomidae; Leptosomus.
OX NCBI_TaxID=188344 {ECO:0000313|EMBL:KFQ04039.1, ECO:0000313|Proteomes:UP000053001};
RN [1] {ECO:0000313|EMBL:KFQ04039.1, ECO:0000313|Proteomes:UP000053001}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N330 {ECO:0000313|EMBL:KFQ04039.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; KK669776; KFQ04039.1; -; Genomic_DNA.
DR Proteomes; UP000053001; Unassembled WGS sequence.
DR GO; GO:0005694; C:chromosome; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0046975; F:histone H3K36 methyltransferase activity; IEA:InterPro.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR CDD; cd19172; SET_SETD2; 1.
DR Gene3D; 2.170.270.10; SET domain; 1.
DR InterPro; IPR006560; AWS_dom.
DR InterPro; IPR003616; Post-SET_dom.
DR InterPro; IPR001214; SET_dom.
DR InterPro; IPR046341; SET_dom_sf.
DR InterPro; IPR044437; SETD2/Set2_SET.
DR InterPro; IPR042294; SETD2_animal.
DR PANTHER; PTHR46711; HISTONE-LYSINE N-METHYLTRANSFERASE SETD2; 1.
DR PANTHER; PTHR46711:SF1; HISTONE-LYSINE N-METHYLTRANSFERASE SETD2; 1.
DR Pfam; PF17907; AWS; 1.
DR Pfam; PF00856; SET; 1.
DR SMART; SM00570; AWS; 1.
DR SMART; SM00508; PostSET; 1.
DR SMART; SM00317; SET; 1.
DR SUPFAM; SSF82199; SET domain; 1.
DR PROSITE; PS51215; AWS; 1.
DR PROSITE; PS50868; POST_SET; 1.
DR PROSITE; PS50280; SET; 1.
PE 4: Predicted;
KW Chromatin regulator {ECO:0000256|ARBA:ARBA00022853};
KW Chromosome {ECO:0000256|ARBA:ARBA00022454};
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000313|EMBL:KFQ04039.1}; Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000053001};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:KFQ04039.1}.
FT DOMAIN 1273..1327
FT /note="AWS"
FT /evidence="ECO:0000259|PROSITE:PS51215"
FT DOMAIN 1329..1446
FT /note="SET"
FT /evidence="ECO:0000259|PROSITE:PS50280"
FT DOMAIN 1453..1469
FT /note="Post-SET"
FT /evidence="ECO:0000259|PROSITE:PS50868"
FT REGION 23..356
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 400..437
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 463..552
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 661..704
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 749..787
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 807..958
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 976..1025
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1081..1220
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1617..1655
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1697..1778
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 23..38
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 39..53
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 54..71
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 88..104
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 105..175
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 203..255
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 256..270
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 271..327
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 328..353
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 494..547
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 661..677
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 837..853
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 867..891
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 892..914
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 934..952
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1134..1160
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1161..1213
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1617..1649
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1728..1746
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFQ04039.1"
FT NON_TER 1812
FT /evidence="ECO:0000313|EMBL:KFQ04039.1"
SQ SEQUENCE 1812 AA; 201612 MW; E5B6C3A1E6966ACE CRC64;
LLLSPPVEAE VAALKEPCHA VPKEALEPEV KQDAASRGSE ERVTQNVPEQ PEITPQKEDS
HIGKEDEVSD GSKGAPLCSR RQGLKRKFSQ SDGTLLGSES DEDSVRTSSS QRSHEQKISS
TEKERDPRRS SASLRGDDLG KSSSRSKSDR DEKYSSYSKS ERDSRYTSSR SRSDRERRRS
RSHSRSRSDR GSRTSSSYSR SERSHYYESD RRYHRSSPYR ERSRYSRSYA DSRARESSDS
EDEYRRTHSR SSDSRRTSSH SSSSYRDSRT SSYSKSDRDS KVESSYADAE RRGRSSSKAD
RDSKRTSESE VTKRCSPLDE LGYRKGTSHS KPDSNVNSSR YKSTPSKTPT PKPDKFKSSF
CCTESIEEIK QQSNSLDLET SCLKSNEIRV SIAKKFEREK TLSPLDQLND SPAFKKADES
KAGFANSKSE ELAGNECHDS VKEQETLLKI KHDQLRTCLP VELSVNGSPE GRADGLATSS
ASKPEDVAVS SDDSLCRSEA SPVVKTSPSY PLPSNGFESV YASQEQEPDD SRVQSSECNS
PFRQAEAPVP QQQGEAIPLP VLNVDHTKAL LELDDQAPPG DKTKEPVFCY ISDEATPALY
HSEVEIEAEP ADVKVTSETF LDMQIELQTV TCDYESTEDH HPKAACDDEH GQPLHKISLA
VESSSRDPSQ DGSSLRLSSD HPVPEEIVSS KWDVPPPGGC PELLPRSEAE EMLDLDAQHV
DLGSAKSKLS FRDEHSYYSA VPLERRGREV VEESAVPTEG VGPDDVRVRC PGASAEKDEG
NEPLVGSAFP DALFPSCDVV VTAEETETVT QAPTCDSSGN AAEFVPAGHE DYSDTGESDS
EGGSDDSDTE DSDSDDGAPR KRLQSVVVVP KNSTIAMEES SPGSSRSSQG TRRFSDHWDD
ERPEPSRTYY EERLESMASK GGPPVESRCS PRGMEKSPAT STELSTALTA DSHGKPNADE
RLTLKELMAV GRPIGRQDEQ PFCLPESFES ADKFRHQMSS SKPDSRQGKG GLNQSGLGDL
SRLDGFQATE DLGHLSWDFT QSEKPSSTYQ QPDSSFGVYS GYVYQPGSGV YGGSQGYWQG
NGYWDARSAS RPSAVSYDRI QGQVPDSLTE DHEEYEEDDR WEVDCKARFP SPSGKGQTPG
QKEKGSVQAH EISSNSTKEL VPGGEKKEEV KVLEKNDAKE RGPPKKRRPE LESDSESDVD
SREKKKVKLE GEQVESAPQD SSMVGRLCIM DDFRDPQRWK EFAKQGKMPC YFDLIEENVY
LTERKKNKSH RDIKRMLCEC PPLSKEERAQ GEVACGEDCL NRLLMIECSS RCPNGDYCSN
RRFQKKQHAD VEVILTEKKG WGLRAAKDLP SNTFVLEYCG EVLDHKEFKA RVKEYARNKN
IHYYFMALKN DEIIDATQKG NCSRFMNHSC EPNCETQKWT VNGQLRVGFF TTKLVPSGSE
LTFDYQFQRY GKEAQKCFCG SANCRGYLGG ENRVSIRAAG GKMKKERSRK KDSVDGELEA
LLENGEGLSD KNQVLSLSRL MVRIETLEQK LTCLKLIQNT HSQSCLKSFL ECHGLSLLWI
WMTELGDGRG STANNLKLQL EIMKTLELLP IPTKNMLEES KVLPIIQRWA QTKTAVPQLS
EGDGYSSENT SRAHTPLNTP DLSTKQSAEG DTDTPKKLVF RRLKIISENS MDSAISDTTS
ELEGKEGKED LDQLEGAPME GSEEQQPQQQ EIKAAVDAPV ESSKPQAAEL EAEPEAEVKE
SNGAKLEEPI TMETPSQDEE EGVSDVESER SQEQTDKIVD VSDLATRLLD SWKELKEVYR
IPKKSQAEKE NS
//
