ID A0A091Q4R1_LEPDC Unreviewed; 547 AA.
AC A0A091Q4R1;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=Sulfotransferase {ECO:0000256|RuleBase:RU361155};
DE EC=2.8.2.- {ECO:0000256|RuleBase:RU361155};
DE Flags: Fragment;
GN ORFNames=N330_12264 {ECO:0000313|EMBL:KFQ14538.1};
OS Leptosomus discolor (Madagascar cuckoo roller) (Cuculus discolor).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Coraciiformes; Leptosomidae; Leptosomus.
OX NCBI_TaxID=188344 {ECO:0000313|EMBL:KFQ14538.1, ECO:0000313|Proteomes:UP000053001};
RN [1] {ECO:0000313|EMBL:KFQ14538.1, ECO:0000313|Proteomes:UP000053001}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N330 {ECO:0000313|EMBL:KFQ14538.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Glycan metabolism; heparan sulfate biosynthesis.
CC {ECO:0000256|ARBA:ARBA00005093}.
CC -!- PATHWAY: Glycan metabolism; heparin biosynthesis.
CC {ECO:0000256|ARBA:ARBA00004841}.
CC -!- SIMILARITY: Belongs to the sulfotransferase 1 family. NDST subfamily.
CC {ECO:0000256|ARBA:ARBA00010420}.
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DR EMBL; KK685892; KFQ14538.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A091Q4R1; -.
DR PhylomeDB; A0A091Q4R1; -.
DR UniPathway; UPA00756; -.
DR UniPathway; UPA00862; -.
DR Proteomes; UP000053001; Unassembled WGS sequence.
DR GO; GO:0015016; F:[heparan sulfate]-glucosamine N-sulfotransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0019213; F:deacetylase activity; IEA:UniProt.
DR GO; GO:0015012; P:heparan sulfate proteoglycan biosynthetic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0030210; P:heparin biosynthetic process; IEA:UniProtKB-UniPathway.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR021930; Heparan_SO4_deacetylase.
DR InterPro; IPR037359; NST/OST.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000863; Sulfotransferase_dom.
DR PANTHER; PTHR10605:SF45; BIFUNCTIONAL HEPARAN SULFATE N-DEACETYLASE_N-SULFOTRANSFERASE 4; 1.
DR PANTHER; PTHR10605; HEPARAN SULFATE SULFOTRANSFERASE; 1.
DR Pfam; PF12062; HSNSD; 1.
DR Pfam; PF00685; Sulfotransfer_1; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|PIRSR:PIRSR637359-3};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000053001};
KW Transferase {ECO:0000256|RuleBase:RU361155, ECO:0000313|EMBL:KFQ14538.1}.
FT DOMAIN 1..180
FT /note="Heparan sulphate-N-deacetylase"
FT /evidence="ECO:0000259|Pfam:PF12062"
FT DOMAIN 270..519
FT /note="Sulfotransferase"
FT /evidence="ECO:0000259|Pfam:PF00685"
FT ACT_SITE 279
FT /note="For sulfotransferase activity"
FT /evidence="ECO:0000256|PIRSR:PIRSR637359-1"
FT BINDING 377
FT /ligand="3'-phosphoadenylyl sulfate"
FT /ligand_id="ChEBI:CHEBI:58339"
FT /evidence="ECO:0000256|PIRSR:PIRSR637359-2"
FT BINDING 482
FT /ligand="3'-phosphoadenylyl sulfate"
FT /ligand_id="ChEBI:CHEBI:58339"
FT /evidence="ECO:0000256|PIRSR:PIRSR637359-2"
FT BINDING 498..502
FT /ligand="3'-phosphoadenylyl sulfate"
FT /ligand_id="ChEBI:CHEBI:58339"
FT /evidence="ECO:0000256|PIRSR:PIRSR637359-2"
FT DISULFID 483..493
FT /evidence="ECO:0000256|PIRSR:PIRSR637359-3"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFQ14538.1"
FT NON_TER 547
FT /evidence="ECO:0000313|EMBL:KFQ14538.1"
SQ SEQUENCE 547 AA; 63629 MW; 42EADC57542838F0 CRC64;
QALLETQNLL RTQVANFTFN LGFSGKFYHT GTEEEDEGDD LLLRSVDEFW WFPHMWSHMQ
PHLFHNESSL VEQMILNKEF AIEHSIPTGM GYAVAPHHSG VYPVHIQLYE AWKKVWHIRV
TSTEEYPHLK PARYRRGFIH NGIMVLPRQT CGLFTHTIFY KEYPGGPQEL DKSIQGGELF
LTILLNPISI FMTHLSNYGN DRLGLYTFAN LANFVKSSTN LNLQTLPPVQ LAQKYFELFP
EQTDPLWQNP CDDKRHRDIW SRDKTCDHLP KFLVIGPQKT GTTALYLFLL MHPSIISNLP
SPKTFEEVQF FNGNNYHKGI DWYMDFFPTP SNTTTDLLFE KSANYFHSEE APKRAASLIP
KAKIITILID PSDRAYSWYQ HQRSHEDPAA LKFNFYEVIT SSHWAPSEIR TLQKRCLTPG
WYAVHIERWL THYPASQLLI IDGQQLRSDP ATVMDEVQKF LGVSPHYNYS EALTFDPQKG
FWCQLLEGGK TKCLGKSKGR KYPPMDQESR AFLSSYYRDH NVELSKLLHR LGQPLPSWLR
QELQKVR
//
