ID A0A091Q5V6_LEPDC Unreviewed; 2021 AA.
AC A0A091Q5V6;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE RecName: Full=non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
DE Flags: Fragment;
GN ORFNames=N330_02680 {ECO:0000313|EMBL:KFQ15587.1};
OS Leptosomus discolor (Madagascar cuckoo roller) (Cuculus discolor).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Coraciiformes; Leptosomidae; Leptosomus.
OX NCBI_TaxID=188344 {ECO:0000313|EMBL:KFQ15587.1, ECO:0000313|Proteomes:UP000053001};
RN [1] {ECO:0000313|EMBL:KFQ15587.1, ECO:0000313|Proteomes:UP000053001}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N330 {ECO:0000313|EMBL:KFQ15587.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-
CC [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001433};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC EC=2.7.11.1; Evidence={ECO:0000256|ARBA:ARBA00000775};
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; KK688442; KFQ15587.1; -; Genomic_DNA.
DR PhylomeDB; A0A091Q5V6; -.
DR Proteomes; UP000053001; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0043226; C:organelle; IEA:UniProt.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0009966; P:regulation of signal transduction; IEA:UniProt.
DR CDD; cd14067; STKc_LRRK1; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 3.
DR Gene3D; 3.30.70.1390; ROC domain from the Parkinson's disease-associated leucine-rich repeat kinase 2; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR032171; COR.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR020859; ROC_dom.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR PANTHER; PTHR48055; LEUCINE-RICH REPEAT RECEPTOR PROTEIN KINASE EMS1; 1.
DR PANTHER; PTHR48055:SF13; LEUCINE-RICH REPEAT SERINE_THREONINE-PROTEIN KINASE 1; 1.
DR Pfam; PF00023; Ank; 1.
DR Pfam; PF16095; COR; 1.
DR Pfam; PF13855; LRR_8; 1.
DR Pfam; PF00069; Pkinase; 1.
DR Pfam; PF08477; Roc; 1.
DR SMART; SM00248; ANK; 4.
DR SMART; SM00364; LRR_BAC; 8.
DR SMART; SM00369; LRR_TYP; 8.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF52058; L domain-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS51450; LRR; 2.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS51424; ROC; 1.
PE 4: Predicted;
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:KFQ15587.1};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000053001};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527};
KW Transferase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:KFQ15587.1}.
FT DOMAIN 644..838
FT /note="Roc"
FT /evidence="ECO:0000259|PROSITE:PS51424"
FT DOMAIN 1254..1537
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REGION 1853..1883
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFQ15587.1"
FT NON_TER 2021
FT /evidence="ECO:0000313|EMBL:KFQ15587.1"
SQ SEQUENCE 2021 AA; 226056 MW; D3F07E0ABAC178A3 CRC64;
SQLQPRMYWC VGTDEAAVCR GSNMEPQNGT VDMGGKQSTV GEVSIIQTPV TESIQDAYKA
GDTSKAQELI KLSCEETALQ VEKCQLLGIA AAYGDLQAVR YLLKEALVVL PTEPNDDNAA
VVAAYFGHKD VVKELLDSLR GKPIGLPLPV LKLFGSCPST CQQLLNWMLA IACQQGHLDV
VKLLIRAYSA DPESCAVRKN EFPVLIRLPL YAAIKAGNED VAVFLLRNGA FFCSYILMDS
PESSKHLLRK YFIETSPLPG SAPAKTALCV NWSNLKLPWV DLDWLIDISC QITELDLSAN
CLVSLPSVIP WGLINLRKLS LADNQLTELP SVQSSDEIIC TRLLEVDVSS NRLSTLPSGF
LHLKNLKKLI ASKNYMEKLF DEENTTNWIG LRKLQEFDVS DNRLVELPTV FLYCFKSLNI
LNVSRNQLKV FPDPWACPLK CCKASRNSFE FLPDALTIFW KNHLREVDFS ENSLKEVPPG
LFQLEALVSL KLLGNQLVTL PSQDKWNCKQ LKSLDLSKNQ LGKSDEGFKT KRIPFFTTKS
RVRCGPEAGP FLEFPAFLSD SLEVLYLNDN QLDSVPQSVC LLKGLTELYL GNNPGIRELP
PELGQLANLW QLDIEELNIS NVPAEIRKEG PKTVLAYLRA QLRRAEKCKL MKMIVIGPPR
QGKSTLIEIL QTGKVPQMMH SDATIRTTKW ELPKPVGHKA KVDSVEFNVW DIGGPASMST
VNQCFFTDKA LYIVVWNLAL GEEAVANLQF WLLNIEAKAP NSAVLVVGTH LDLIETKFRV
ERIATLRAYV LALCRSPSGS RATGFPDITF KHLHELSCRT LEGLDGLRQL IFHVTCNMKD
VGSSICSQKL AGRLIPRSYL SLQEAVLSEQ HRRSQSDDVQ YLTDRQIELI IEQTPGNDIK
DYEDLQTAIN FLIETGTLLH FPDTSHGLRN LYFLDPVWLS ECLQRIFNIK SSKSVAKNGV
IRAEDLRMLL VGTGFTEQTE EQYFQFLAKF EIALPVANNS YLLPHLLPTK PALDIHGFCH
QTTNTVQRVF KMSFVPVGFW QRFIARMLIS LAEMDLQLFE NKKNTKTRNK KVTIYSFTGT
QRNRCSTFRV KRTHTVYWQE GLFVTFDGGY LSVESSDVNW KKKKSGGIKI ICQSEVRDFS
AMAFITDHVN SLIDQWFPAL TAMESDGTLL MEQYVPCHIC AASKPEENEC GEKAEDAQYF
NMEDCVLTAI ELDYIMCPNH PDIPVSLQEL VPELFMTDFP ARLFLENSKL ECSENENNVL
GQGGSGTVIY RARYQGKPVA VKRFQIKKCK GSPTSAADTM LKHLRAMDAM KNFSEFRQEA
SMLHSLQHPC IVSLIGISIH PLCFALELAP LGSLTTVLSE NSKGSSFVPL GHMLTHKIAY
QIVTGLAYLH KKNIIFCDLK SDNILVWSLD VKEHVNIKLS DYGISRQSFH EGALGVEGTP
GYQAPEIRPR IVYDEKVDMF SYGMVLYELL SGQRPVLGQH QLQIAKKLSK GIRPVLGQPE
EVQLYRMQAL MMECWDTKPE KRPLAISVVG QMKDPTFATF MYLLSCGKQS SFFSSQGQEY
TVVFWDGKED TRNYTVVNPE KGVIEVERMS CPGMKLCCQL KFQNALWAAT EDQKISVYGL
QGMCPLKTPQ KGLDTPATVS CFLVMPVVKK NAYVVLAGLS DGLVAVFSVS QGIPGDSCSY
LCSHTANRSK FNIPDDDPRQ NPYPVKAMEI ANSGAEVWYS NGPGVLIIDC ATMEISRRLE
PFSPPSVITS IACNSECHGE EVVWCLDDKS NFLVMYHVTT YQLCARYFCG DCSPLRDMFT
IQQPSAAIPA TAPVNPRAME SHPPGDMSII YSPEVGTQIL NHQDSLTDYC SVSSYSSSPP
DRITRCPSSL PSSPMSSSSG PVSTDFESFD KFHELKPSLD HDAMPVGDDT QHLQAVKILP
VKDLIWIPRR GGDIIVIGLE KESGTQRGRV IAVLKAGELA PYGALVDAAL IAKDTVVCCF
ENENMEWCLA VWRGWSARDF DVFYQAYEEL GRLETCMRKR R
//
