ID A0A091QHM9_9GRUI Unreviewed; 973 AA.
AC A0A091QHM9;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 22-FEB-2023, entry version 19.
DE RecName: Full=MMS19 nucleotide excision repair protein {ECO:0000256|RuleBase:RU367072};
DE Flags: Fragment;
GN ORFNames=N332_07180 {ECO:0000313|EMBL:KFQ27065.1};
OS Mesitornis unicolor (brown roatelo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Gruiformes; Mesitornithidae; Mesitornis.
OX NCBI_TaxID=54374 {ECO:0000313|EMBL:KFQ27065.1, ECO:0000313|Proteomes:UP000053369};
RN [1] {ECO:0000313|EMBL:KFQ27065.1, ECO:0000313|Proteomes:UP000053369}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N332 {ECO:0000313|EMBL:KFQ27065.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Key component of the cytosolic iron-sulfur protein assembly
CC (CIA) complex, a multiprotein complex that mediates the incorporation
CC of iron-sulfur cluster into apoproteins specifically involved in DNA
CC metabolism and genomic integrity. In the CIA complex, MMS19 acts as an
CC adapter between early-acting CIA components and a subset of cellular
CC target iron-sulfur proteins. {ECO:0000256|RuleBase:RU367072}.
CC -!- SUBUNIT: Component of the CIA complex. {ECO:0000256|RuleBase:RU367072}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, spindle
CC {ECO:0000256|RuleBase:RU367072}. Nucleus
CC {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|RuleBase:RU367072}.
CC -!- SIMILARITY: Belongs to the MET18/MMS19 family.
CC {ECO:0000256|ARBA:ARBA00009340, ECO:0000256|RuleBase:RU367072}.
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DR EMBL; KK798477; KFQ27065.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A091QHM9; -.
DR Proteomes; UP000053369; Unassembled WGS sequence.
DR GO; GO:0097361; C:CIA complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-UniRule.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005819; C:spindle; IEA:UniProtKB-SubCell.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-UniRule.
DR GO; GO:0016226; P:iron-sulfur cluster assembly; IEA:UniProtKB-UniRule.
DR GO; GO:0097428; P:protein maturation by iron-sulfur cluster transfer; IEA:UniProtKB-UniRule.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 2.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR039920; MET18/MMS19.
DR InterPro; IPR024687; MMS19_C.
DR InterPro; IPR029240; MMS19_N.
DR PANTHER; PTHR12891; DNA REPAIR/TRANSCRIPTION PROTEIN MET18/MMS19; 1.
DR PANTHER; PTHR12891:SF0; MMS19 NUCLEOTIDE EXCISION REPAIR PROTEIN HOMOLOG; 1.
DR Pfam; PF12460; MMS19_C; 1.
DR Pfam; PF14500; MMS19_N; 1.
DR SUPFAM; SSF48371; ARM repeat; 2.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|RuleBase:RU367072};
KW Cytoskeleton {ECO:0000256|RuleBase:RU367072};
KW DNA damage {ECO:0000256|RuleBase:RU367072};
KW DNA repair {ECO:0000256|RuleBase:RU367072};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU367072};
KW Reference proteome {ECO:0000313|Proteomes:UP000053369};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 12..273
FT /note="MMS19 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF14500"
FT DOMAIN 513..924
FT /note="MMS19 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF12460"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFQ27065.1"
FT NON_TER 973
FT /evidence="ECO:0000313|EMBL:KFQ27065.1"
SQ SEQUENCE 973 AA; 107400 MW; B4696EF72E4DB3AB CRC64;
VKDGSWTVLQ LVEALGSCLE NADPRTRGRG IQLLSQVLLQ CYSLLQEKEV LHLVLFYENR
LQDHHLVIPA VLQGLRALSM CEVLSQGLAV SVLKAIFQEV HVQSLLQLDR HTVYSIITNF
MDTREEELKS LGADFTFGFI QVMDGEKDPR NLLVAFQIVR DLITKNYALG PFVEELFEVT
SCYFPIDFTP PPNDPHGIQR EDLILSLRAV LASTPQFAEF LLPLLIEKMD SDLQSAKLDS
LQTLTACCAI YGQKELQEFL PSLWSSLRRE VFQTASEKVE TECLAALHAL SACLSCSVLS
SDTEDLLDSF LSSILQDCRH HLCEPDMKLV WPSAKLLQAA AGASLRAYHH VTHSVLPLLL
EQYNKHLQSS QRRTILEMLL GFLELQQKWG HVEEDENTLL LLQAPVCSVV FSALTDPSVQ
LQLVGIRALT VLGSLQGFVS PSDLELVVDH LIRLALCEED SQSSEAAMEA AGSLAPIYPK
VFSGRMVPRL EEELQSERDE ESSRNHCSLR QCCLQALAAV STHTSIVRET VPVLLQHLRK
VQKGSEAGNV QDIVSVCQSL HRVALQCQQD AEGCWYYHQT VVPCLLAKVQ AATQESTHPL
LGKALLEEEV LAAMVAVISA ATTHLSPELA AQSVAHVVPL FLDGEVSFLP QNSFPCSFQP
FEDREHLEAQ RRLVALLMAF VCCLPRNVRC CSGNCPFTAT TAGKCFAGLV NKHPAGQQLD
EILQLAVNRM EPGLAEGPRR MQALTLLLWV TKALVLRYHP LSSHLTDKLL GLLGDAELGP
AVADGFSLLM AESPDVLHKG CHADVRIMFR QRFFTDNVPK LVQGFHGAGP DVKANYLKGL
VQGCWLLTSP VSSHSQLLSL LLEALSCSDH VVQLSTLSCL QPLLPEAPQI MSLHVDTLVT
KFLSLTSSPT MAVRIAALRC AHALTSLPTT VLLPYKARVI RALARPLDDK KRLVRKEAVA
ARGEWFLLGS PGR
//
