ID A0A091QQT7_9GRUI Unreviewed; 726 AA.
AC A0A091QQT7;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 24-JAN-2024, entry version 43.
DE SubName: Full=Guanine nucleotide exchange factor VAV3 {ECO:0000313|EMBL:KFQ29553.1};
DE Flags: Fragment;
GN ORFNames=N332_14542 {ECO:0000313|EMBL:KFQ29553.1};
OS Mesitornis unicolor (brown roatelo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Gruiformes; Mesitornithidae; Mesitornis.
OX NCBI_TaxID=54374 {ECO:0000313|EMBL:KFQ29553.1, ECO:0000313|Proteomes:UP000053369};
RN [1] {ECO:0000313|EMBL:KFQ29553.1, ECO:0000313|Proteomes:UP000053369}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N332 {ECO:0000313|EMBL:KFQ29553.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; KK802144; KFQ29553.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A091QQT7; -.
DR Proteomes; UP000053369; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd20869; C1_VAV3; 1.
DR CDD; cd01223; PH_Vav; 1.
DR CDD; cd00160; RhoGEF; 1.
DR CDD; cd11981; SH3_VAV3_1; 1.
DR CDD; cd11978; SH3_VAV3_2; 1.
DR Gene3D; 3.30.60.20; -; 1.
DR Gene3D; 1.10.418.10; Calponin-like domain; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 2.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR001331; GDS_CDC24_CS.
DR InterPro; IPR002219; PE/DAG-bd.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR037832; PH_Vav.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR047015; VAV3_SH3_1.
DR InterPro; IPR035734; VAV3_SH3_2.
DR PANTHER; PTHR45818:SF1; GUANINE NUCLEOTIDE EXCHANGE FACTOR VAV3; 1.
DR PANTHER; PTHR45818; PROTEIN VAV; 1.
DR Pfam; PF00130; C1_1; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR Pfam; PF00017; SH2; 1.
DR Pfam; PF07653; SH3_2; 2.
DR PRINTS; PR00401; SH2DOMAIN.
DR PRINTS; PR00452; SH3DOMAIN.
DR SMART; SM00109; C1; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SMART; SM00252; SH2; 1.
DR SMART; SM00326; SH3; 2.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR SUPFAM; SSF50044; SH3-domain; 2.
DR PROSITE; PS00741; DH_1; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50001; SH2; 1.
DR PROSITE; PS50002; SH3; 2.
DR PROSITE; PS00479; ZF_DAG_PE_1; 1.
DR PROSITE; PS50081; ZF_DAG_PE_2; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000053369};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}; Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 86..265
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 294..396
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 407..456
FT /note="Phorbol-ester/DAG-type"
FT /evidence="ECO:0000259|PROSITE:PS50081"
FT DOMAIN 482..550
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 559..653
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 668..726
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFQ29553.1"
FT NON_TER 726
FT /evidence="ECO:0000313|EMBL:KFQ29553.1"
SQ SEQUENCE 726 AA; 83823 MW; B51D730CC8868E65 CRC64;
QVIETLSKLS RTPIAIGTGI RPFPTEESVD DEDVYKCLPD LIDETGVDED EDLYDCVYGE
DEGGEVYEDL MKDEAAQQPK YTENDIRSCC LAEIKQTEEK YTETLESIEK FFMVPLKRFL
SASEFDTVFI NIPDLVKIHK NLTQDINDSI VNKNDQNLYQ IFINYKERLV IYGQYCSQVE
IAISCLDNIS KTKEDVKLKL EECSKRANNG KFTLRDLLVV PMQRVLKYHL LLQELVKHTT
DPMEKANLKL ALDAMKDLAQ YVNEVKRDNE TLREIRQFQL SIENLNHSLL QYGRPQGDGE
IRITTLDKRA RQDRHIFLFD LAVIVCKRRG DNYEMKEIID LQKYKITNNP TTDKENKKWS
YGFYLIHIQG QNGLEVYCKT KDLKKKWLEQ FQMALSNIRP DYADTSFHEF KMHTFSRVTS
CKVCQMLLRG TFYQGYLCSK CGAGAHKECL GRLDNCGRAN SGASSFISSV SMVSVHSQYS
QKGLPKMQVI RNYNGIPQPA TQDGPPLHIQ IGDTIELIRG DAHSLFWQGR NLTTGELGFF
PSDAVKPSPC TIFIDLCYRF AGAMERLQAE SELINRVNST YLVRHRTKES GEYAISIKYN
NEVKHIKILT RDGFFHIAEN RKFKNLMELI EYYKHHSLKE GFRSLDTTLQ FPYKESENSM
GQRMLSPKVI GIAIARYDFC ARDMRELSLL KGDVVKIYTK MSANGWWRGE VNGRVGWFPS
TYVEED
//
