ID A0A091QZ70_MERNU Unreviewed; 1094 AA.
AC A0A091QZ70;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE SubName: Full=Acyl-CoA synthetase family member 4 {ECO:0000313|EMBL:KFQ31971.1};
DE Flags: Fragment;
GN ORFNames=N331_04291 {ECO:0000313|EMBL:KFQ31971.1};
OS Merops nubicus (Northern carmine bee-eater).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Coraciiformes; Meropidae; Merops.
OX NCBI_TaxID=57421 {ECO:0000313|EMBL:KFQ31971.1, ECO:0000313|Proteomes:UP000052967};
RN [1] {ECO:0000313|EMBL:KFQ31971.1, ECO:0000313|Proteomes:UP000052967}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N331 {ECO:0000313|EMBL:KFQ31971.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the ATP-dependent AMP-binding enzyme family.
CC {ECO:0000256|ARBA:ARBA00006432}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; KK708616; KFQ31971.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A091QZ70; -.
DR Proteomes; UP000052967; Unassembled WGS sequence.
DR GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR GO; GO:0006629; P:lipid metabolic process; IEA:UniProtKB-KW.
DR CDD; cd17654; A_NRPS_acs4; 1.
DR Gene3D; 2.40.10.480; -; 1.
DR Gene3D; 3.30.300.30; -; 1.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR048005; AASDH_AMP.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR InterPro; IPR018391; PQQ_beta_propeller_repeat.
DR InterPro; IPR002372; PQQ_repeat.
DR InterPro; IPR011047; Quinoprotein_ADH-like_supfam.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR44394; BETA-ALANINE-ACTIVATING ENZYME; 1.
DR PANTHER; PTHR44394:SF1; BETA-ALANINE-ACTIVATING ENZYME; 1.
DR Pfam; PF00501; AMP-binding; 1.
DR Pfam; PF13193; AMP-binding_C; 1.
DR Pfam; PF13360; PQQ_2; 1.
DR Pfam; PF13570; PQQ_3; 2.
DR SMART; SM00564; PQQ; 7.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR SUPFAM; SSF50998; Quinoprotein alcohol dehydrogenase-like; 1.
DR PROSITE; PS00455; AMP_BINDING; 1.
PE 3: Inferred from homology;
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Reference proteome {ECO:0000313|Proteomes:UP000052967}.
FT DOMAIN 9..414
FT /note="AMP-dependent synthetase/ligase"
FT /evidence="ECO:0000259|Pfam:PF00501"
FT DOMAIN 478..535
FT /note="AMP-binding enzyme C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13193"
FT NON_TER 1094
FT /evidence="ECO:0000313|EMBL:KFQ31971.1"
SQ SEQUENCE 1094 AA; 121575 MW; 01290905C7CF82EC CRC64;
MTLQEMVNQA ARLYSDRKAV WFDECNDKPP SFYTYSTVVK LAMELTAFLQ KHCDQRGKCE
IGLYCYPGIN LPSWILGILQ VPAAYSPIDP DAPPMLSTHF MKKSNLQYVL VENDKVNKFC
ASCVGSFYHN SSTIEHIGLT LFQMNSSVAD LNLQVDSVKS ECEPSTALGG SQPAHTVCQE
QTKGKPSGEA YVDVGQKYSL AYVLHTSGTT GIPKIVRVPH KCIVPNIQHL KTIFEITEDD
VLFLASPLTF DPSVIELFVA LTSGASVLVV PNAVKMMPVE LAAALFHHHH VTVLQATPTL
LRKFGAHIIK SMVLSANTSL RVLALGGEAF PGLNLLKSWK HKENKTNIFN LYGITEVSSW
ATCYKIPEEV FSSDFRTDFP VPLGSPLLGT KVEVRDTNGS AVLEGEGQIF IGGEERICFL
DDEITVPMGT MRETGDFGRV QDAELFFLGR KDNQIKRHGK RFNMECLQQA AEDLCHIEAC
AVTWYQEEKL ILFVVPKGVL EERKTLEELR KHVPAYAVPD ELVLIKALPV TSHGKVDISE
LNKIYQNHLS SRRRDSRLSG AEELWERLQY LWKSVLCLPD DSTGISKDAV FLYSGGDSLQ
GLRFHDEIEI LVGKAVPGLL EVILSRSIGE VYTHILKILF PDEDQLMNYD NVVKRKLTGN
SGEEFHRKYI KLKSERSLEV ASEFISFIAL SRGNHFFSMN FTKSFMQPSN TVQVGVELLQ
QPSFLHSASP RVTKSHVQGY EMEKGAELLF HVRWKSNTRK CVDASPLVAV PAKEEAPAAV
YIGSHSHAMQ AIDLELGEVK WEKNLGDRIE SSACISRCGN FIIVGCYDGL VYVLQRSNGE
IHWTFVTEDA VKSSPVVDPS SGLVYTGSHD QHVYALDIYK KACVWKLHCE SGAVFSSPCL
SSFPHHLYVA TLGGLLLAVN PVTGHKIWKS FLRKPLFSSP HCSEKYVCVG CVDGNLYCYS
HSGEKVWQFS TSGPVFSSPC ISSLTKEEIF FGSHDGFIYC CNMEGNLLWK FEATSSVYGT
PFIFQSDHLK NKILLAAVST DGKVWILNAK NGTAEGVSML PGEVFSSPVV WGTKLVVGCR
NDYVYCLDLS VTGK
//
