ID A0A091R5Q4_MERNU Unreviewed; 821 AA.
AC A0A091R5Q4;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 24-JAN-2024, entry version 41.
DE SubName: Full=Ras GTPase-activating protein 1 {ECO:0000313|EMBL:KFQ35148.1};
DE Flags: Fragment;
GN ORFNames=N331_02710 {ECO:0000313|EMBL:KFQ35148.1};
OS Merops nubicus (Northern carmine bee-eater).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Coraciiformes; Meropidae; Merops.
OX NCBI_TaxID=57421 {ECO:0000313|EMBL:KFQ35148.1, ECO:0000313|Proteomes:UP000052967};
RN [1] {ECO:0000313|EMBL:KFQ35148.1, ECO:0000313|Proteomes:UP000052967}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N331 {ECO:0000313|EMBL:KFQ35148.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; KK713966; KFQ35148.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A091R5Q4; -.
DR Proteomes; UP000052967; Unassembled WGS sequence.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0050896; P:response to stimulus; IEA:UniProt.
DR CDD; cd08400; C2_Ras_p21A1; 1.
DR CDD; cd13260; PH_RASA1; 1.
DR CDD; cd05391; RasGAP_p120GAP; 1.
DR CDD; cd10354; SH2_Cterm_RasGAP; 1.
DR CDD; cd11788; SH3_RasGAP; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR039360; Ras_GTPase.
DR InterPro; IPR035842; RasGAP_C_SH2.
DR InterPro; IPR023152; RasGAP_CS.
DR InterPro; IPR001936; RasGAP_dom.
DR InterPro; IPR035652; RasGAP_SH3.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR10194:SF146; RAS GTPASE-ACTIVATING PROTEIN 1; 1.
DR PANTHER; PTHR10194; RAS GTPASE-ACTIVATING PROTEINS; 1.
DR Pfam; PF00168; C2; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00616; RasGAP; 1.
DR Pfam; PF00017; SH2; 1.
DR Pfam; PF00018; SH3_1; 1.
DR PRINTS; PR00401; SH2DOMAIN.
DR SMART; SM00239; C2; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00323; RasGAP; 1.
DR SMART; SM00252; SH2; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50004; C2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS00509; RAS_GTPASE_ACTIV_1; 1.
DR PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
DR PROSITE; PS50001; SH2; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000052967};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 53..115
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 125..215
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 248..351
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 351..464
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 522..716
FT /note="Ras-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50018"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFQ35148.1"
FT NON_TER 821
FT /evidence="ECO:0000313|EMBL:KFQ35148.1"
SQ SEQUENCE 821 AA; 94430 MW; F026DD3F0F84102F CRC64;
RIIAMCGDYY IGGRRFASLS DLIGYYSHVS CLLKGEKLLF PVAPPEASSK PVEDRRRVRA
ILPYTKVPET DEISFLKGDM FIVHNELEDG WMWVTNLRTD EQGLIVEDLV EEVGREEDPH
EGKIWFHGKI SKQEAYNLLM TVGQVCSFLV RPSDNTPGDY SLYFRTSENI QRFKICPTSN
NQFMMGGRYY NSIADIIEHY RKEQIVEGYY LKEPVPMQHQ EQVLNDTVDG KEIYNTIRRK
TKDAFYKNIV KKGYLLKKSK GKRWKNLYFI LEGNDAQLIY FESEKRATKP KGLIDLSVCS
VYGVHDSLFG RPNCFQIVVQ HFSEEHYIFY FAGETPEQAQ DWMKALQMFC SLRKTSPGAS
NKRLRQVSSL ILHVEEAHTL PVKHFTNPYC NIYLNSVQVA KTHIREGQNP VWSEEFVFDD
LSSDINRFEI SLSNKTKKSK DPDILFMRCQ LSRLQKGHAT DEWFQLSSHV PLKGIEPGSL
RVRARYSMEK IMPEEEYSEF KELILQKELH VVYALSHVCG QDRTLLAGIL LKIFLHEKLE
SLLLRTLNDR EISMEDEATT LFRATTLAST LMEQYMKATA TSFVHHALKD SILKIMESKQ
SCELNPSKLE KNEDVNTNLA HLLSILSELV EKIFMAAEIL PPTLRYIYGC LQKSVQNKWP
ANTTMRTRVV SGFVFLRLIC PAILNPRMFN IISDSPSPTA ARTLTLVAKS VQNLANLVEF
GAKEPYMEGV NPFIKSNKHR MIMFLDELGN VPELPDPTEH SRTDLSRDLA ALHEICVAHS
DELRTLSNER GVMQHVLKKL LAITELLQQK QNQYSVSNNS R
//
