ID A0A091R7Y7_9GRUI Unreviewed; 639 AA.
AC A0A091R7Y7;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 24-JAN-2024, entry version 24.
DE RecName: Full=Macoilin {ECO:0000256|ARBA:ARBA00021882};
DE AltName: Full=Transmembrane protein 57 {ECO:0000256|ARBA:ARBA00031129};
DE Flags: Fragment;
GN ORFNames=N332_06762 {ECO:0000313|EMBL:KFQ35049.1};
OS Mesitornis unicolor (brown roatelo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Gruiformes; Mesitornithidae; Mesitornis.
OX NCBI_TaxID=54374 {ECO:0000313|EMBL:KFQ35049.1, ECO:0000313|Proteomes:UP000053369};
RN [1] {ECO:0000313|EMBL:KFQ35049.1, ECO:0000313|Proteomes:UP000053369}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N332 {ECO:0000313|EMBL:KFQ35049.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Plays a role in the regulation of neuronal activity.
CC {ECO:0000256|ARBA:ARBA00003440}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004477}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004477}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}. Nucleus membrane
CC {ECO:0000256|ARBA:ARBA00004232}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004232}. Rough endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004269}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004269}.
CC -!- SIMILARITY: Belongs to the macoilin family.
CC {ECO:0000256|ARBA:ARBA00008298}.
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DR EMBL; KK810288; KFQ35049.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A091R7Y7; -.
DR Proteomes; UP000053369; Unassembled WGS sequence.
DR GO; GO:0031965; C:nuclear membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0030867; C:rough endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0023041; P:neuronal signal transduction; IEA:InterPro.
DR InterPro; IPR019130; Macoilin.
DR PANTHER; PTHR47464; MACOILIN; 1.
DR PANTHER; PTHR47464:SF2; MACOILIN; 1.
DR Pfam; PF09726; Macoilin; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000053369};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 6..25
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 46..64
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 97..115
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 131..151
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 298..350
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 610..639
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 358..526
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 568..595
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 298..326
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 610..630
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFQ35049.1"
FT NON_TER 639
FT /evidence="ECO:0000313|EMBL:KFQ35049.1"
SQ SEQUENCE 639 AA; 73466 MW; 6D9E2D3D9F1D4417 CRC64;
LFYSTFLYLK FLVVWALVLL ADFVLEFRFE YLWPFWLFIR SVYDSFRYQG LAFSVFFVCV
AFTSNIICLL FIPIQWLFFA ASTYVWVQYV WHTERGVCLP TVSLWILFVY IEAAIRFKDL
KNFHVDLCRP FAAHCIGYPV VTLGFGFKSY VSYKMRLRKQ KEVQKENEFY MQLLQQALPP
EQQMLQRQER EAEEGKGLSD MDSSMLLQHN GGIPANKKLS ATLPELEYRE KGKEKDKDAK
KHNLGINNNI LQPVDSKIQE IEYMENHINS KRLNNDLVGS TENLLKEDSC TASSKNYKNV
SGVVNSSPRS HSATNGSIPS SSTKNEKKQK CASKSPSTHK DLMENCIPNN QLSKPDALVR
LEQDIKKLKA DLQASRQIEQ ELRSQISSLT NTERGIRSEI GQLRQENELL QNKLHNAVQM
KQKDKQMISQ LEKKLKAEQE ARAFVEKQLM EEKKRKKLEE ATAARAVAFA AATRGECTET
LRNRIRELET ECKKLTIDIK LKEDQIRELE MKVQELRKYK ENEKDTEVLM SALSAMQDKT
QHLENSLSAE TRIKLDLFSA LGDAKRQLEI AQGQIIQKDQ EIKDLKQKIA EVMAVMPSIT
YTAATSTLSP VSPHYSSKFV ETSPSGLDPN ASVYQPLKK
//
