ID A0A091RC99_MERNU Unreviewed; 160 AA.
AC A0A091RC99;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 03-MAY-2023, entry version 31.
DE RecName: Full=Secreted frizzled-related protein 3 {ECO:0000256|ARBA:ARBA00020513};
DE AltName: Full=Frizzled-related protein 1 {ECO:0000256|ARBA:ARBA00031515};
DE AltName: Full=FrzB-1 {ECO:0000256|ARBA:ARBA00029575};
DE Flags: Fragment;
GN ORFNames=N331_03208 {ECO:0000313|EMBL:KFQ36837.1};
OS Merops nubicus (Northern carmine bee-eater).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Coraciiformes; Meropidae; Merops.
OX NCBI_TaxID=57421 {ECO:0000313|EMBL:KFQ36837.1, ECO:0000313|Proteomes:UP000052967};
RN [1] {ECO:0000313|EMBL:KFQ36837.1, ECO:0000313|Proteomes:UP000052967}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N331 {ECO:0000313|EMBL:KFQ36837.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Soluble frizzled-related proteins (sFRPS) function as
CC modulators of Wnt signaling through direct interaction with Wnts. They
CC have a role in regulating cell growth and differentiation in specific
CC cell types. SFRP3/FRZB appears to be involved in limb skeletogenesis.
CC Antagonist of Wnt8 signaling. Regulates chondrocyte maturation and long
CC bone development. {ECO:0000256|ARBA:ARBA00025169}.
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DR EMBL; KK716569; KFQ36837.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A091RC99; -.
DR Proteomes; UP000052967; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR CDD; cd03581; NTR_Sfrp3_like; 1.
DR Gene3D; 2.40.50.120; -; 1.
DR InterPro; IPR001134; Netrin_domain.
DR InterPro; IPR018933; Netrin_module_non-TIMP.
DR InterPro; IPR035813; NTR_Sfrp3.
DR InterPro; IPR008993; TIMP-like_OB-fold.
DR Pfam; PF01759; NTR; 1.
DR SMART; SM00643; C345C; 1.
DR SUPFAM; SSF50242; TIMP-like; 1.
DR PROSITE; PS50189; NTR; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Reference proteome {ECO:0000313|Proteomes:UP000052967};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}.
FT DOMAIN 19..139
FT /note="NTR"
FT /evidence="ECO:0000259|PROSITE:PS50189"
FT REGION 134..160
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFQ36837.1"
FT NON_TER 160
FT /evidence="ECO:0000313|EMBL:KFQ36837.1"
SQ SEQUENCE 160 AA; 17950 MW; 68ADECFFA1DC49C4 CRC64;
DFPMDSNNGN CRGAGIERCK CKPIKATQKT YLRNNYNYVI RAKVKEVKMK CHDVTAVVEV
KEILKSSLVN IPKDTVNLHT NSGCLCPPLS ANEEYIIMGY EDEERSRLLL VEGSIAEKWK
DRLGKKVKRW DQKLRHLGKG KGESGHSDPA PKPGKPSGAR
//
