ID A0A091RDQ3_9GRUI Unreviewed; 763 AA.
AC A0A091RDQ3;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE RecName: Full=Palmitoyltransferase {ECO:0000256|RuleBase:RU079119};
DE EC=2.3.1.225 {ECO:0000256|RuleBase:RU079119};
DE Flags: Fragment;
GN ORFNames=N332_14121 {ECO:0000313|EMBL:KFQ37993.1};
OS Mesitornis unicolor (brown roatelo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Gruiformes; Mesitornithidae; Mesitornis.
OX NCBI_TaxID=54374 {ECO:0000313|EMBL:KFQ37993.1, ECO:0000313|Proteomes:UP000053369};
RN [1] {ECO:0000313|EMBL:KFQ37993.1, ECO:0000313|Proteomes:UP000053369}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N332 {ECO:0000313|EMBL:KFQ37993.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=hexadecanoyl-CoA + L-cysteinyl-[protein] = CoA + S-
CC hexadecanoyl-L-cysteinyl-[protein]; Xref=Rhea:RHEA:36683, Rhea:RHEA-
CC COMP:10131, Rhea:RHEA-COMP:11032, ChEBI:CHEBI:29950,
CC ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:74151;
CC EC=2.3.1.225; Evidence={ECO:0000256|ARBA:ARBA00023340};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:36684;
CC Evidence={ECO:0000256|ARBA:ARBA00023340};
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane
CC {ECO:0000256|ARBA:ARBA00004653}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004653}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- DOMAIN: The DHHC domain is required for palmitoyltransferase activity.
CC {ECO:0000256|RuleBase:RU079119}.
CC -!- SIMILARITY: Belongs to the DHHC palmitoyltransferase family.
CC ERF2/ZDHHC9 subfamily. {ECO:0000256|ARBA:ARBA00023463}.
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DR EMBL; KK815231; KFQ37993.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A091RDQ3; -.
DR Proteomes; UP000053369; Unassembled WGS sequence.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-KW.
DR GO; GO:0019706; F:protein-cysteine S-palmitoyltransferase activity; IEA:UniProtKB-EC.
DR InterPro; IPR001594; Palmitoyltrfase_DHHC.
DR PANTHER; PTHR12349; ANKYRIN REPEAT AND LEM DOMAIN-CONTAINING PROTEIN 2; 1.
DR PANTHER; PTHR12349:SF1; PALMITOYLTRANSFERASE ZDHHC8; 1.
DR Pfam; PF01529; DHHC; 1.
DR PROSITE; PS50216; DHHC; 1.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000256|RuleBase:RU079119};
KW Membrane {ECO:0000256|RuleBase:RU079119};
KW Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW Reference proteome {ECO:0000313|Proteomes:UP000053369};
KW Transferase {ECO:0000256|RuleBase:RU079119, ECO:0000313|EMBL:KFQ37993.1};
KW Transmembrane {ECO:0000256|RuleBase:RU079119};
KW Transmembrane helix {ECO:0000256|RuleBase:RU079119}.
FT TRANSMEM 12..32
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU079119"
FT TRANSMEM 113..137
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU079119"
FT TRANSMEM 149..175
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU079119"
FT TRANSMEM 218..240
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU079119"
FT DOMAIN 67..187
FT /note="Palmitoyltransferase DHHC"
FT /evidence="ECO:0000259|Pfam:PF01529"
FT REGION 292..333
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 424..451
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 507..532
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 658..683
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 713..747
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 316..330
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 658..679
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 715..747
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFQ37993.1"
FT NON_TER 763
FT /evidence="ECO:0000313|EMBL:KFQ37993.1"
SQ SEQUENCE 763 AA; 83808 MW; F8DDD917E494BCC3 CRC64;
CPWLTKAISP AIPVYNGLVF LFVLANFSMA TFMDPGVFPR ADEDEDKDDD FRAPLYKNVE
IKGIQVRMKW CATCHFYRPP RCSHCSVCDN CVEDFDHHCP WVNNCIGRRN YRYFFLFLLS
LSTHMVGVFT FGLIFILNHM EKLGAAHTTI TMAVMCVAGL FFIPVIGLTG FHIVLVARGR
TTNEQVTGKF RGGVNPFTRG CCGNVEHVLC SPLAPRKLLL SLCLVLWLLF ILIMNIGQLI
RYIVEPKKKQ AVSVKPPFFR PDLSEQQITV KISDNGIQAN LNRSKSKISL EGLDDKSMDV
QPPLPPKGDP SKYSELKGQL GTSEESGLSP KLISPPTPAM YKYRPAFSNN PKVHYHATAE
QITMQEGHSQ GALIEEDGRS LDYQSEPSLD IPSYRKSSLH KTYQSSPLQI DSFAINSRSL
SLKSAGRRGT DKVPLHPIKS EGAASTPYKS IFSPNSLSNR NGSLSYDSLL NPMSPSGRKC
IAHSAVSSVG YHSPYLSAKM CHLRGSELQR QPPQSFSPVL GGPAPHQRDP SPVRYDNLSK
TIMASIQERK EMEEREKLLH SHPDSVFADS GVYDTPSSYS LQQVSTLSED PRSMAMRYGS
RDNLMAATSF STRNPILQSS VSSLSSAMTR APRTSTTSLQ ADLANNNVQS HQALQGRVSN
GSYKSPGHQV PSSPTGMPRS PSYGGPKAVS FVNTVEITEV QSVGAQRDDM QLKTPHSKIN
GQPKGITRLG STSSSQGTPV SPARHSNVKK VSGVGGTTYE ISV
//
