GenomeNet

Database: UniProt
Entry: A0A091RTF0_NESNO
LinkDB: A0A091RTF0_NESNO
Original site: A0A091RTF0_NESNO 
ID   A0A091RTF0_NESNO        Unreviewed;      1004 AA.
AC   A0A091RTF0;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   13-FEB-2019, entry version 24.
DE   RecName: Full=Trifunctional purine biosynthetic protein adenosine-3 {ECO:0000256|RuleBase:RU363089};
DE   Includes:
DE     RecName: Full=Phosphoribosylamine--glycine ligase {ECO:0000256|RuleBase:RU363089};
DE              EC=6.3.4.13 {ECO:0000256|RuleBase:RU363089};
DE     AltName: Full=Glycinamide ribonucleotide synthetase {ECO:0000256|RuleBase:RU363089};
DE              Short=GARS {ECO:0000256|RuleBase:RU363089};
DE     AltName: Full=Phosphoribosylglycinamide synthetase {ECO:0000256|RuleBase:RU363089};
DE   Includes:
DE     RecName: Full=Phosphoribosylformylglycinamidine cyclo-ligase {ECO:0000256|RuleBase:RU363089};
DE              EC=6.3.3.1 {ECO:0000256|RuleBase:RU363089};
DE     AltName: Full=AIR synthase {ECO:0000256|RuleBase:RU363089};
DE              Short=AIRS {ECO:0000256|RuleBase:RU363089};
DE     AltName: Full=Phosphoribosyl-aminoimidazole synthetase {ECO:0000256|RuleBase:RU363089};
DE   Includes:
DE     RecName: Full=Phosphoribosylglycinamide formyltransferase {ECO:0000256|RuleBase:RU363089};
DE              EC=2.1.2.2 {ECO:0000256|RuleBase:RU363089};
DE     AltName: Full=5'-phosphoribosylglycinamide transformylase {ECO:0000256|RuleBase:RU363089};
DE     AltName: Full=GAR transformylase {ECO:0000256|RuleBase:RU363089};
DE              Short=GART {ECO:0000256|RuleBase:RU363089};
DE   Flags: Fragment;
GN   ORFNames=N333_01256 {ECO:0000313|EMBL:KFQ45718.1};
OS   Nestor notabilis (Kea).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Psittaciformes; Psittacidae; Nestor.
OX   NCBI_TaxID=176057 {ECO:0000313|EMBL:KFQ45718.1};
RN   [1] {ECO:0000313|EMBL:KFQ45718.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BGI_N333 {ECO:0000313|EMBL:KFQ45718.1};
RA   Zhang G., Li C.;
RT   "Genome evolution of avian class.";
RL   Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(6S)-10-formyltetrahydrofolate + N(1)-(5-phospho-D-
CC         ribosyl)glycinamide = (6S)-5,6,7,8-tetrahydrofolate + H(+) +
CC         N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide;
CC         Xref=Rhea:RHEA:15053, ChEBI:CHEBI:15378, ChEBI:CHEBI:57453,
CC         ChEBI:CHEBI:57454, ChEBI:CHEBI:58426, ChEBI:CHEBI:58457;
CC         EC=2.1.2.2; Evidence={ECO:0000256|RuleBase:RU363089};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine + ATP
CC         = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ADP + H(+) +
CC         phosphate; Xref=Rhea:RHEA:23032, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:58478,
CC         ChEBI:CHEBI:137981, ChEBI:CHEBI:456216; EC=6.3.3.1;
CC         Evidence={ECO:0000256|RuleBase:RU363089};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=5-phospho-D-ribosylamine + ATP + glycine = ADP + H(+) +
CC         N(1)-(5-phospho-D-ribosyl)glycinamide + phosphate;
CC         Xref=Rhea:RHEA:17453, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:57305, ChEBI:CHEBI:58089,
CC         ChEBI:CHEBI:58457, ChEBI:CHEBI:456216; EC=6.3.4.13;
CC         Evidence={ECO:0000256|RuleBase:RU363089};
CC   -!- PATHWAY: Purine metabolism; IMP biosynthesis via de novo pathway;
CC       5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-
CC       phospho-D-ribosyl)glycinamide: step 2/2.
CC       {ECO:0000256|RuleBase:RU363089}.
CC   -!- PATHWAY: Purine metabolism; IMP biosynthesis via de novo pathway;
CC       N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-
CC       ribose 1-diphosphate: step 2/2. {ECO:0000256|RuleBase:RU363089}.
CC   -!- PATHWAY: Purine metabolism; IMP biosynthesis via de novo pathway;
CC       N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide from N(1)-(5-
CC       phospho-D-ribosyl)glycinamide (10-formyl THF route): step 1/1.
CC       {ECO:0000256|RuleBase:RU363089}.
CC   -!- SIMILARITY: In the C-terminal section; belongs to the GART family.
CC       {ECO:0000256|RuleBase:RU363089}.
CC   -!- SIMILARITY: In the N-terminal section; belongs to the GARS family.
CC       {ECO:0000256|RuleBase:RU363089}.
CC   -!- SIMILARITY: In the central section; belongs to the AIR synthase
CC       family. {ECO:0000256|RuleBase:RU363089}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   -----------------------------------------------------------------------
DR   EMBL; KK932553; KFQ45718.1; -; Genomic_DNA.
DR   UniPathway; UPA00074; UER00125.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0004637; F:phosphoribosylamine-glycine ligase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0004641; F:phosphoribosylformylglycinamidine cyclo-ligase activity; IEA:UniProtKB-EC.
DR   GO; GO:0004644; F:phosphoribosylglycinamide formyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006189; P:'de novo' IMP biosynthetic process; IEA:UniProtKB-UniRule.
DR   GO; GO:0009113; P:purine nucleobase biosynthetic process; IEA:UniProtKB-UniRule.
DR   CDD; cd08645; FMT_core_GART; 1.
DR   CDD; cd02196; PurM; 1.
DR   Gene3D; 3.30.1330.10; -; 1.
DR   Gene3D; 3.30.1490.20; -; 1.
DR   Gene3D; 3.90.600.10; -; 1.
DR   Gene3D; 3.90.650.10; -; 1.
DR   HAMAP; MF_00741; AIRS; 1.
DR   HAMAP; MF_00138; GARS; 1.
DR   HAMAP; MF_01930; PurN; 1.
DR   InterPro; IPR011761; ATP-grasp.
DR   InterPro; IPR013815; ATP_grasp_subdomain_1.
DR   InterPro; IPR002376; Formyl_transf_N.
DR   InterPro; IPR036477; Formyl_transf_N_sf.
DR   InterPro; IPR004607; GART.
DR   InterPro; IPR001555; GART_AS.
DR   InterPro; IPR016185; PreATP-grasp_dom_sf.
DR   InterPro; IPR020561; PRibGlycinamid_synth_ATP-grasp.
DR   InterPro; IPR000115; PRibGlycinamide_synth.
DR   InterPro; IPR020560; PRibGlycinamide_synth_C-dom.
DR   InterPro; IPR037123; PRibGlycinamide_synth_C_sf.
DR   InterPro; IPR020559; PRibGlycinamide_synth_CS.
DR   InterPro; IPR020562; PRibGlycinamide_synth_N.
DR   InterPro; IPR010918; PurM-like_C_dom.
DR   InterPro; IPR036676; PurM-like_C_sf.
DR   InterPro; IPR016188; PurM-like_N.
DR   InterPro; IPR036921; PurM-like_N_sf.
DR   InterPro; IPR004733; PurM_cligase.
DR   InterPro; IPR011054; Rudment_hybrid_motif.
DR   PANTHER; PTHR10520; PTHR10520; 1.
DR   Pfam; PF00586; AIRS; 1.
DR   Pfam; PF02769; AIRS_C; 1.
DR   Pfam; PF00551; Formyl_trans_N; 1.
DR   Pfam; PF01071; GARS_A; 1.
DR   Pfam; PF02843; GARS_C; 1.
DR   Pfam; PF02844; GARS_N; 1.
DR   SMART; SM01210; GARS_C; 1.
DR   SUPFAM; SSF51246; SSF51246; 1.
DR   SUPFAM; SSF52440; SSF52440; 1.
DR   SUPFAM; SSF53328; SSF53328; 1.
DR   SUPFAM; SSF55326; SSF55326; 1.
DR   SUPFAM; SSF56042; SSF56042; 1.
DR   TIGRFAMs; TIGR00877; purD; 1.
DR   TIGRFAMs; TIGR00878; purM; 1.
DR   TIGRFAMs; TIGR00639; PurN; 1.
DR   PROSITE; PS50975; ATP_GRASP; 1.
DR   PROSITE; PS00184; GARS; 1.
DR   PROSITE; PS00373; GART; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|PROSITE-ProRule:PRU00409,
KW   ECO:0000256|RuleBase:RU363089};
KW   Ligase {ECO:0000256|RuleBase:RU363089};
KW   Manganese {ECO:0000256|RuleBase:RU363089};
KW   Metal-binding {ECO:0000256|RuleBase:RU363089};
KW   Multifunctional enzyme {ECO:0000256|RuleBase:RU363089};
KW   Nucleotide-binding {ECO:0000256|PROSITE-ProRule:PRU00409,
KW   ECO:0000256|RuleBase:RU363089};
KW   Purine biosynthesis {ECO:0000256|RuleBase:RU363089}.
FT   DOMAIN      113    320       ATP-grasp. {ECO:0000259|PROSITE:PS50975}.
FT   NON_TER       1      1       {ECO:0000313|EMBL:KFQ45718.1}.
FT   NON_TER    1004   1004       {ECO:0000313|EMBL:KFQ45718.1}.
SQ   SEQUENCE   1004 AA;  106959 MW;  72FC31A5AB14CC3E CRC64;
     RLMADRVLVI GSGGREHALA WKLAQSPHVK HVFVAPGNAG TADSGKISNS AISVSNHAAL
     AQFCRDQEIK LVVVGPEVPL AAGIVDDLTA TGVRCFGPTA KAAQLESSKS FTKAFLDRHE
     IPTARWKSFT DPKAACSFIN SANFPALVVK ASGLAAGKGV IVASNKEEAC KAVTEIMQDK
     TFGTAGETVV VEELLEGEEV SCLCFTDGVT IAPMPPAQDH KRLMDEDEGP NTGGMGAYSP
     APQISKDLLQ EIRDTVLQKT VDGMRKEGVL YFGVLYAGLM LTKDGPKVLE FNCRFGDPEC
     QVILPLLKSD LYEVMQAVIN KKLSSSMPVW FEDSAAVTVV MASEGYPGTY PKGLEITGLS
     KAKQLGLQVF HAGTALKDGK VVTNGGRVLT VTAIKEDLMT ALQEANKGVA AIHFKGAIYR
     KDIGYRAIAF LKQSRGLTYK NSGVDIAAGN TLVQKIKPLA AATSRSGCNA ELGGFAGLFD
     LKAAGYKDPV LVSGTDGVGT KLKIAQVCKK HDTIGQDLVA MCVNDILAQG AEPLFFLDYF
     ACGKLDVEVA QGVIAGIAEA CKKAGCALLG GETAEMPGMY PPGEYDLAGF AVGAVERGQM
     LPQLERIADG DVVIGVASSG VHSNGYSLVR KIVEKSSFDF ASPVDVSGDQ TLGDILLTPT
     KIYSKTLLPI LRSGHVKAYA HITGGGLLEN IPRVLPDSFG VILDALTWKI PEIFCWLHKE
     GNLSEEEMAR TFNCGIGAVL VVQKELAQQV LKDIERHEAA WLIGKVVSLQ KGSAHVKVHN
     LLRALQANRS LSLHSHIQGK IQTNKVKVAV LISGTGTNLE ALINSTKKST SFAQIVLVVS
     NKAGVEGLRK AERAGISTRV IDHKLYESRT EFDSAVDKVL GEFSVELICL AGFMRILSGP
     FVKKWEGKIL NIHPSLLPSF KGANAHKLVL QAGVRVTGCT VHFVAEEVDA GAIIFQEAVP
     VKVGDTVETL SERVKEAEHR AFPAALQLVA SGAVQLGEAG KIYW
//
DBGET integrated database retrieval system