ID A0A091S1U1_NESNO Unreviewed; 1113 AA.
AC A0A091S1U1;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 28-JUN-2023, entry version 37.
DE SubName: Full=Activity-dependent neuroprotector homeobox protein {ECO:0000313|EMBL:KFQ49226.1};
GN ORFNames=N333_11727 {ECO:0000313|EMBL:KFQ49226.1};
OS Nestor notabilis (Kea).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Psittaciformes; Psittacidae; Nestor.
OX NCBI_TaxID=176057 {ECO:0000313|EMBL:KFQ49226.1, ECO:0000313|Proteomes:UP000053840};
RN [1] {ECO:0000313|EMBL:KFQ49226.1, ECO:0000313|Proteomes:UP000053840}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N333 {ECO:0000313|EMBL:KFQ49226.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PROSITE-ProRule:PRU00108,
CC ECO:0000256|RuleBase:RU000682}.
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DR EMBL; KK938999; KFQ49226.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A091S1U1; -.
DR Proteomes; UP000053840; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd00086; homeodomain; 1.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR038861; ADNP/ADNP2.
DR InterPro; IPR045762; ADNP_Znf.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR15740:SF1; ACTIVITY-DEPENDENT NEUROPROTECTOR HOMEOBOX PROTEIN; 1.
DR PANTHER; PTHR15740; NEUROPROTECTIVE PEPTIDE-CONTAINING PROTEIN; 1.
DR Pfam; PF19627; ADNP_N; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR SMART; SM00389; HOX; 1.
DR SMART; SM00355; ZnF_C2H2; 8.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 1.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Homeobox {ECO:0000256|PROSITE-ProRule:PRU00108,
KW ECO:0000256|RuleBase:RU000682};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00108}; Reference proteome {ECO:0000313|Proteomes:UP000053840};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00042}.
FT DOMAIN 513..541
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 771..814
FT /note="Homeobox"
FT /evidence="ECO:0000259|PROSITE:PS50071"
FT DNA_BIND 773..815
FT /note="Homeobox"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT REGION 336..390
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 405..443
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 583..610
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 693..714
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 867..1113
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 347..390
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 695..712
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 891..912
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 913..961
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 981..996
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1010..1025
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1027..1053
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1054..1085
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1097..1113
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1113 AA; 124766 MW; 216F0422FB4FA344 CRC64;
MFQLPVNNLG SLRKARKTVK KILSDIGLEY CKEHIEDFKQ FEPNDFYLKN TTWEDVGLWD
PSLTKNQDYR TKPFCCSACP FSSKFFSAYK SHFRNVHSED FENRILLNCP YCTFNADKKT
LETHIKIFHA PNANTPSGGI STFKDKNKHD SLKPKQADSV DQAVYYCKKC TYRDPLYEIV
RKHIYREHFQ HVAAPYVAKG GEKSLNGAVP LSSSTREEGS IHCKRCLFMP KSYEALVQHV
IEDHERIGYQ VTAMIGHTNV VVPRSKPLML IAPKPQDKKS MGLPQRMGPL SPGSVRSLSS
QQMMNRLTIP KPTLNSAGVN MMSNVHLQQN NYGVKSVPPS YVGQPGGRLN LSGSAQVSIP
QQSQTMKQFS TSGNGRPYTL GGEQRSQASA RYSLQSANSS SLSSAQLKQT SLSQSQSASR
VLGQSGSKSP VAATGPSPVN TSSTQKWKIC TICNELFPEN VYSVHFEKEH KAEKVPAVAN
YIMKIHNFTS KCLYCNRYLP TDTLLNHMLI HGLSCPYCRS TFNDVEKMAA HMRMVHVDEE
MGPKTDSTLT FDLTLQQGSH TNIHLLVTTY NLRDAPAESV AYHAQNTPPV PPKPQPKVQE
KSDVPVKSSP QAAVPYKKDV GKTLCPLCFS ILKGPISDAL AHHLRERHQV IQTVHPVEKK
LTYKCIHCLG VYTSNMTAST ITLHLVHCRG VGKTQNGQDK GTSSSRLSQS PAVAPVKRTY
EHMEFSLMKK RKMDDDDSPS AFEEKPEEPV VLALDPKGHE DDSYEARKTF LTKYFNKQPY
PTRREIEKLA ASLWLWKSDI ASHFSNKRKK CVRDCEKYKP GVLLGFNMKE LNKVKHEMDF
DAEWLFENHD EKNSRVNVSK TVDKKINLEK DNESSSDSYE NIEEEYNESG SPFGQRISDS
GGKTSSDSTV ENPEDSISKE IVEENTLQSP EKSDQKQEES SKYEEILSAE EPTKLVGDVS
DSDGDQDDQD DAVEWKDGAS QSESGPGSQQ VSDFEDNTSE VKPEVWTDES SQSEDASSSK
PAVETKGGGS ESDEEQSKWK NRSYGKVEEF WSKDQSQWKN ASEIEESLSN QQMEWQNSTI
DSEDGEQFDS VTDGVAEPMH SSLTSVELSS QQA
//
