ID   A0A091S2H9_NESNO        Unreviewed;       887 AA.
AC   A0A091S2H9;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   24-JAN-2024, entry version 24.
DE   SubName: Full=Patched domain-containing protein 4 {ECO:0000313|EMBL:KFQ48887.1};
GN   ORFNames=N333_01681 {ECO:0000313|EMBL:KFQ48887.1};
OS   Nestor notabilis (Kea).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Psittaciformes; Psittacidae; Nestor.
OX   NCBI_TaxID=176057 {ECO:0000313|EMBL:KFQ48887.1, ECO:0000313|Proteomes:UP000053840};
RN   [1] {ECO:0000313|EMBL:KFQ48887.1, ECO:0000313|Proteomes:UP000053840}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BGI_N333 {ECO:0000313|EMBL:KFQ48887.1};
RA   Zhang G., Li C.;
RT   "Genome evolution of avian class.";
RL   Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the patched family.
CC       {ECO:0000256|ARBA:ARBA00005585}.
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DR   EMBL; KK938514; KFQ48887.1; -; Genomic_DNA.
DR   RefSeq; XP_010012130.1; XM_010013828.1.
DR   AlphaFoldDB; A0A091S2H9; -.
DR   GeneID; 104405197; -.
DR   KEGG; nnt:104405197; -.
DR   CTD; 442213; -.
DR   OrthoDB; 2876883at2759; -.
DR   Proteomes; UP000053840; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR   InterPro; IPR003392; Ptc/Disp.
DR   InterPro; IPR000731; SSD.
DR   PANTHER; PTHR10796:SF15; PATCHED DOMAIN-CONTAINING PROTEIN 4; 1.
DR   PANTHER; PTHR10796; PATCHED-RELATED; 1.
DR   Pfam; PF02460; Patched; 1.
DR   SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR   PROSITE; PS50156; SSD; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000053840};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        26..44
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        304..326
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        338..357
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        378..396
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        416..434
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        502..521
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        694..720
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        727..748
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        754..778
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        799..817
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        829..851
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          278..433
FT                   /note="SSD"
FT                   /evidence="ECO:0000259|PROSITE:PS50156"
SQ   SEQUENCE   887 AA;  101107 MW;  1CEDCA15174BB4C7 CRC64;
     MLRQGIHRGL QSFFYKLGLF VSRHPVFFLT VPAVLTIIFG FSLLNRFQPD TDLESLVAPS
     HSLAKIERSL ASSLFSLDQS KSQLYSDLHT PGRYGRVILL SKPGGNILHQ ADVILQIHRA
     VLEMKVNYKG YNYTFSHLCV LRNQDKKCVL DDIISVLEDL RQAALSNKTT ARVQVSYPNT
     KLKDGRSSFI GHQLGGVLEV PNSKDQRVKS ARAIQITYYL QTYGSVTQDL IGEKWESEFC
     KLMHKMQLDH QDLQLYSLAS FSLWNDFHQT SLLARGKILV SLMLILLTAT LSSSMKDCLR
     SKPFLGLLGV LTICISSVTA AGIFFITDGK YNSTLLGIPF FAMGHGTKGV FELLSGWRRT
     RENLPFKDRV ADAYSDVMVS YTMTSSLYFI AFGMGASPFT NIEAVKVFCQ NMCVSILLNY
     FYIFSFFGSC LVFAGQLEQN RYHSIFCCKI PSAEYLDRKP VWFQTMMNDG HQHTSHHETD
     PYQHHFIQHF LREHYNEWIT NIYVKPFVVI LYLIYASFSF MGCLQINDGA NIINLLASES
     PSVSYALIQQ KYFSNYSPVI GFYIYEPLEY WNGTVQEDLK TLSQGFNTVS WIEQYYQYLR
     VGNISATNKS DFINILQSSF LKKPEFQHFK NDIIFSKAGD ENNIIASRLY LVARTSENTQ
     REAIELLEKL RPLSLVQSIK FIVFNPTFVF MDHYGLSVTM PVLISGFGIL LMLILTFFLV
     IHPLGNFWLI LSVTSIELGV LGLMTLWNVD MDCISILCLI YTLNFAIDHC APLLYTFVLA
     TEHTRTQCIK NSLQEHGTAI LQNVSSFLIG LVPLLFVPSN LTFTLFKCLL LAGSCTLLHC
     FVILPVFLTF FPPSKKHHKK KKRAKRKERE EIECIEIQEN PDHVTAV
//