ID A0A091S2P2_NESNO Unreviewed; 1190 AA.
AC A0A091S2P2;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE SubName: Full=Zinc finger E-box-binding homeobox 2 {ECO:0000313|EMBL:KFQ50405.1};
DE Flags: Fragment;
GN ORFNames=N333_11955 {ECO:0000313|EMBL:KFQ50405.1};
OS Nestor notabilis (Kea).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Psittaciformes; Psittacidae; Nestor.
OX NCBI_TaxID=176057 {ECO:0000313|EMBL:KFQ50405.1, ECO:0000313|Proteomes:UP000053840};
RN [1] {ECO:0000313|EMBL:KFQ50405.1, ECO:0000313|Proteomes:UP000053840}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N333 {ECO:0000313|EMBL:KFQ50405.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the delta-EF1/ZFH-1 C2H2-type zinc-finger
CC family. {ECO:0000256|ARBA:ARBA00009867}.
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DR EMBL; KK940668; KFQ50405.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A091S2P2; -.
DR Proteomes; UP000053840; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:UniProt.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:UniProt.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 6.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR008598; Di19_Zn-bd.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR24391; HISTONE H4 TRANSCRIPTION FACTOR-RELATED; 1.
DR PANTHER; PTHR24391:SF18; ZINC FINGER PROTEIN 1; 1.
DR Pfam; PF00096; zf-C2H2; 3.
DR Pfam; PF05605; zf-Di19; 1.
DR Pfam; PF12874; zf-met; 1.
DR SMART; SM00389; HOX; 1.
DR SMART; SM00355; ZnF_C2H2; 8.
DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 4.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 5.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 6.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000313|EMBL:KFQ50405.1};
KW Homeobox {ECO:0000313|EMBL:KFQ50405.1};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000053840};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00042}.
FT DOMAIN 187..215
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 217..239
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 258..285
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 975..1002
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 1003..1030
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 1031..1059
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT REGION 1..93
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 732..788
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 807..834
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1093..1190
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 13..28
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 29..53
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 54..72
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 755..788
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 810..834
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1101..1131
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1132..1147
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1148..1190
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFQ50405.1"
FT NON_TER 1190
FT /evidence="ECO:0000313|EMBL:KFQ50405.1"
SQ SEQUENCE 1190 AA; 133413 MW; 6F3C082C61F08CFD CRC64;
VVNYENVVET GSETDEEDKL HIAEDESAIN TLDQETSPAS VPNHESSPHV NQATLPREEE
EDEMRESGVD HTWHNNEILQ ASVDGPEEMK EDYDTMGPEA TIQTTGNNGT VKNANCTSDF
EEYFAKRKLE EGDGHAVSIA EYLQRSDTAI IYPEAPEELS RLGTPEANGQ EENDLPPGTP
DAFAQLLTCP YCDRGYKRLT SLKEHIKYRH EKNEENFSCP LCNYTFAYRT QLERHMVTHK
PGTDQHQMLT QGAGNRKFKC TECGKAFKYK HHLKEHLRIH SGEKPYECPN CKKRFSHSGS
YSSHISSKKC IGLISVNGRM RNNIKTGSSP NSVSSSPTNS AITQLRNKLE NGKPLSMSEQ
TGLLKIKTEP LDFNEYKVLM ASHGFSATSP FMNGGLGATS PLGVHASAQS PMQHLGVGME
APLLGFPAVG SNLSEVQKVL QIVDNTVSRQ KMDCKAEEIS KLKVYHMKDS CSQAEEQGVT
SPSIPPVGLP VVSHNGATKS IIDYTLEKVN EAKACLQSLT TDSRRQLNNI KKEKLRTLID
LVTEDKMIDN HNVSTPFSCQ FCKESFPGPI PLHQHERYLC KMNEEIKAVL QPHENLVPNK
PGVFDKQTLL LSSVLSEKGM TSPINPYKDH MSVLKAYYAM NMEPNSDELL KISIAVGLPQ
EFVKEWFEQR KVYQYSSSRS PSLERASAKV ALAATNNTPT KDSLSARSPI KPVDSITSPS
IAELHNSVTN CDTPLRLTKP PHFTNIKPVD KLDHSRSNTP SPLNLSSTSS KNSHSSSYTP
NSFSSEELQA EPLDLSLPKQ MKEPKSIIAT KNKTKSNSVT LEHNSVSSSS ENSDEPLNLT
FIKKEFSNSN NLDKSTNPVF GMNPFSAKPL YTTLPPQSAF PPATFMPPVQ TSIPGLRPYP
GLDQMSFLPH MAYTYPTGAA TFADMQQRRK YQRKQGFQGE LLDGTPDYMS GLDDMTDSDS
CLSRKKIKKT ESGMYACDLC DKTFQKSSSL LRHKYEHTGK RPHQCQICKK AFKHKHHLIE
HSRLHSGEKP YQCDKCGKRF SHSGSYSQHM NHRYSYCKRE AEEREAAERE AREKGHLEPT
ELLMNRAYLQ SITPQGYSDS EERESMPRDG ESEKEHEKEG EDGYEKLGRQ DGDEEFEEEE
EESENKSMDT DPDTIRDEEE TGDHSMDDSS EDGKMETKSD HEEDNMEDGM
//
