ID A0A091S418_NESNO Unreviewed; 3645 AA.
AC A0A091S418;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 50.
DE RecName: Full=non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
DE Flags: Fragment;
GN ORFNames=N333_01047 {ECO:0000313|EMBL:KFQ51285.1};
OS Nestor notabilis (Kea).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Psittaciformes; Psittacidae; Nestor.
OX NCBI_TaxID=176057 {ECO:0000313|EMBL:KFQ51285.1, ECO:0000313|Proteomes:UP000053840};
RN [1] {ECO:0000313|EMBL:KFQ51285.1, ECO:0000313|Proteomes:UP000053840}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N333 {ECO:0000313|EMBL:KFQ51285.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-
CC [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001433};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC EC=2.7.11.1; Evidence={ECO:0000256|ARBA:ARBA00000775};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; KK941791; KFQ51285.1; -; Genomic_DNA.
DR Proteomes; UP000053840; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd05170; PIKKc_SMG1; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR003152; FATC_dom.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR InterPro; IPR018936; PI3/4_kinase_CS.
DR InterPro; IPR014009; PIK_FAT.
DR InterPro; IPR031559; SMG1.
DR InterPro; IPR035175; SMG1_N.
DR InterPro; IPR039414; SMG1_PIKKc.
DR PANTHER; PTHR11139; ATAXIA TELANGIECTASIA MUTATED ATM -RELATED; 1.
DR PANTHER; PTHR11139:SF71; SERINE_THREONINE-PROTEIN KINASE SMG1; 1.
DR Pfam; PF02260; FATC; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR Pfam; PF15785; SMG1; 1.
DR Pfam; PF17229; SMG1_N; 1.
DR SMART; SM01343; FATC; 1.
DR SMART; SM00146; PI3Kc; 1.
DR SMART; SM01345; Rapamycin_bind; 1.
DR SUPFAM; SSF48371; ARM repeat; 2.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS51189; FAT; 1.
DR PROSITE; PS51190; FATC; 1.
DR PROSITE; PS00916; PI3_4_KINASE_2; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:KFQ51285.1};
KW Nonsense-mediated mRNA decay {ECO:0000256|ARBA:ARBA00023161};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000053840};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 1257..1840
FT /note="FAT"
FT /evidence="ECO:0000259|PROSITE:PS51189"
FT DOMAIN 2108..2447
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
FT DOMAIN 3613..3645
FT /note="FATC"
FT /evidence="ECO:0000259|PROSITE:PS51190"
FT REGION 1..71
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3552..3587
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1958..1985
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1..37
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 38..52
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 54..71
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3552..3567
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFQ51285.1"
FT NON_TER 3645
FT /evidence="ECO:0000313|EMBL:KFQ51285.1"
SQ SEQUENCE 3645 AA; 408793 MW; 940E19785EE9941C CRC64;
RTDSASADQD NLKYSSSRDR GSSASYGLQP SNSAVVSRQR HDDIRVHTDI QNEEKGGYSV
NGGSGENTYG RKSLGQELRV NNVTNPDFTS VPHGNRALAT KDMRKSQERS LSYSDESRLS
NLLRRITRED DRDRRLATVK QLKEFIQQPE NKLVLVKQLD NILTAIHDVL NESSKLLQEL
RQEGACCLGL LCASLSYEAE KIFKWIFSKF SSSTKDEVKL LYLCATYKAL ETVGEKKAFS
SLMQLVMTSL QSILENVDTP ELLCKCVKCI LLVSRCYPHI FSTNFRDTVD ILVGWHIDHT
QKPSLTQQVS GWLQSLEPFW VADLTFSTTL LGQFLEDMEA YAEDLSHVAS GESVDEDIPP
PSVSLPKLAA LLRVFSTVVR SIGERFSPIR GPPITEAYVT DVLYRVMRCV TAANQVFFSE
AVLTAANECV GVLLGSLDPS MTIHCDMVIT YGLDQMENCQ TCGTDYIISV LNLLTLIVEQ
INTKLPSSFV EKLFIPESKL LVLRYHKEKE VRVTSIAQAV YQAVLSLKNI PVLETAYRLI
LGEMTCALNS LLYSLHLPEA CSEIQHDSFK KRILNVDNAK FVVIFDLSAL STIGNAKNSL
IGMWALSPTV FALLSKNLMI VHGDIAVHFP AVQYAVLYTL YSHCSRHDHF ISSSLSSSSP
SLFDGAVIST VTTATKKHFS IILNLLGLLL KKDNLTQDTR KLLMTWALEV AVLMKKSETY
APLFSLPSFH KFCKGLLANT LLEDTNTCLQ ACSSLHALSS SLPDDLLQRC VDVCRVQLVH
SGARVRQTFG KLLKSIPLDV VLSNRTHTEI QEISLALRSH MSKAPSNTFH PQDFSDVISF
ILYGNSHRTG KDNWLERLFY SCQRLDKRDQ PTIPRNLLKT DAVLWQWAVW EAAQFTVLSK
LRTPLGRAQD TFQTIEGIIR SLAAHTLNPD QDVSQWTTAD NDEGHGSNQL RLVLLLQYLE
NLEKLMYNAY EGCANALTSP PKVGLTFFYT NRQTCQDWLT RIRLSIMRVG LLAGQPAVTV
RHGFDLLTEM KTSNSLSQGN ELEVTIMMLV EALCELHCPE AIQGIAVWSS AVVGKSLAWI
NSVAQQAEGR FEKATAEYQE HLCSMTGVDC CITGFDKTVL KLANSNSVNN ASPKHSLNGE
ARKTVLTKPS DSSPEVINYL GNKACECYIS IADWSAVQEW QNMVHDLKKS NSNTSINLKA
DFNYIKSLSS FESGQLTECT EQLELLPGEN INLLAGGSKE KIDMKKLLPN MLSPDPRELQ
KAVEVQLLRS SVCLATAVNH IEQEQKWQSI SENVIKYLKQ TSRIAIGPLR LSTLTVSQSL
PVLSTLQLYC SSALENTVSN RLTSEDCLIP LFNDALRSCK QHDVRPWMHA LRYTVYQNQL
MEKLKEPTVP IKSHLMELGL TAAKFARKRG NIALATRLLA QCSEVQLGKT TTAQDLVQHF
KKLSAPGQID EKWGPELDIE KTKLLYTAGQ STHAMEMLSS CAISFCKSAK AEYAVAKSIL
TLAKWIQAEW KEISGQLKQV YRARQQQNHT GLSTLSKNIY NLIDLPAVNT LEEEYPRIES
ESTVNIGVGE PDFILGQLYH LSSVQAPEVA KSWAALASWA YRWGRKVVDN ASQGEGVRLL
PREKSEVQNL LPDNIAEEDK EKIYGILGQA VCRPAGIQDE DMTLQITENE DNEEDDMVDV
IWRQLLTSCP WLSDLDENAT EGLIKVWRKV VDRIFSLYKL SCSAYFTFLK LNAGQVPLDE
DDPRLHLRNT SEQSTDDVIV MATLRLLRLL VKHAGELRQY LEHGLETTPT APWRGIIPQL
FSRLNHPEVY VRQSICNLLC RVAQDSPHLI LYPAIVGTIS LSSESQTSAD ILTSVFNLGN
KLPSAIPTLL GNIQGEELLG GECDGGSPPA SQESTKDDTK VGLNEDQAMM QDCYSKIVEK
LSAANPTMVL QVQMLVAELR RVTVLWDELW LGVLLQQHMY VLRRIQQLED EVKRVQNNNT
LRKEEKIAIM REKHTALMKP IVFALEHVRS ITAAPAETPH EKWFQDNYGE AIENALEKLK
NPLNPAKPGS SWLPFKEVML SLQQRAQKRA SYLLRLEEIS PWLAAMMNTE IALPGEVSTR
DTVTIHSVGS TITILPTKTK PKKLLFLGSD GKNYPYLFKG LEDLHLDERI MQFLSIVNTM
FATINRQETP RFHARHYSVT PLGTRSGLIQ WVDGATPLFG LYKRWQQREA ALQAQKAQDS
YQTPQNPGIV PRPSELYYSK IGPALKAVGL SLDVSRRDWP LNVMRAVLEE LMEATPPNLL
AKELWSSCTT PDEWWRVTQS YARSTAVMSM VGYIIGLGDR HLDNVLIDMT TGEVVHIDYN
VCFEKGKSLR VPEKVPFRMT HNIETALGVT GVEGVFRLSC EQVLHIMRRG RETLLTLLEA
FVYDPLVDWT AGGEAGFAGA VYGGGGQQAE NKQSKREMER DITRSLFSSR VAEIKVNWFK
NRDEMLAVLP KLDSSLEEYL NLQEQLTDVE KLQGKLLEEI EFLEGAEGVD HPSHTLQHRY
SEHTQLQSQQ RAVQEAIQVK LNEFEQWITH YQTAFSNLEA TQLASLLQEI STQMDLGPPS
YVPATAFLQN AGQAHLISQC EQLEGEVGAL LQQRRSVLRG CLEQLHNYAT VALQYPKAVF
QKHRIEQWKT WMEELICNMT IERCQDIFRK YEMQYAPQPP PSMCQFITAT EMTLQRYAAD
INNRLIRQVE RLKQEAVTVP VCEEQLKEIE RCIKVFLHEN GEEGSLSLAS VIISALCTLT
RRNLMMEGAA SSAGEQLVDL TSRDGAWFLE ELCSMSGNVT CLVQLLKQCH LVPQDLDIPN
PIEASEAVHL ANGVYISLQE LNSNFRQIIF PEALRCLMKG EYTLESMLHE LDNLIEQTTD
GVPLQTLVES LQAYLRNAAM GLEEETHTHY IDVARVLHAQ YGELIQPRNG SVDETPKMSA
GQMLLVAFDG MFAQVETAFG LLIEKLNKME IPVAWRKIDI IREARSTQVN FFDDDNNRQV
LEEIFFLKRL QTIKEFFRLC GTFSKTLSGI SSLEEQNAVN GPVQIVNVKA LYRNSCFSED
QMAKPIKAFT ADFVRQLLIG LPNQALGLTL CSFISALGVD IIAQVEAKDF GAESKVSVDD
LCKKAVEHNI QIGKFSQLVM NRATVLASSY DTAWKKHDLV RRLETSISSC KTSLQRVQLH
IAMFQWQHED LLISRPQAIS VTPPPRSAIL ASMKKKLHTL SQIEASIATV QEKLAALEAS
IEQRLKWAGG ANPALAPVLQ DFDATIAERR NLVLKESQRA SQVTFLCSNI IHFESLRTRT
AEALNLDAAL FELLKRCQQM CSFASQFNSS VSELELRLLQ RVGTGLEHPI GSSEWLHSAH
KQLTQEISTQ RTVQTEREQQ IETVCETIQN LVDSIKTVLT GHNRQLGDVK HLLKAMAKDE
EAALADGEDV PYENSVRQFL GEYKSWQDNI QTVLFTLVQV MGQVRSQEHV EMLQEITPTL
KELKTQSQSV YNNLVGFASP LVTDTSNECS SPTSAATYQP TFAAAVRSNT GQKTQPEVMS
QNARKLIQKN LATSADTPPS TVPGTGRSAA CSPKKTARDP KTGKAVQERN SYAVSVWKRV
KAKLEGRDVD PNRRMSVAEQ VDFVIKEATN LDNLAQLYEG WTAWV
//
