ID A0A091S469_NESNO Unreviewed; 1190 AA.
AC A0A091S469;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 51.
DE SubName: Full=Histone-lysine N-methyltransferase NSD2 {ECO:0000313|EMBL:KFQ50641.1};
DE Flags: Fragment;
GN ORFNames=N333_09108 {ECO:0000313|EMBL:KFQ50641.1};
OS Nestor notabilis (Kea).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Psittaciformes; Psittacidae; Nestor.
OX NCBI_TaxID=176057 {ECO:0000313|EMBL:KFQ50641.1, ECO:0000313|Proteomes:UP000053840};
RN [1] {ECO:0000313|EMBL:KFQ50641.1, ECO:0000313|Proteomes:UP000053840}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N333 {ECO:0000313|EMBL:KFQ50641.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; KK941015; KFQ50641.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A091S469; -.
DR Proteomes; UP000053840; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0042054; F:histone methyltransferase activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR CDD; cd21991; HMG-box_NSD2; 1.
DR CDD; cd15651; PHD2_NSD2; 1.
DR CDD; cd15654; PHD3_NSD2; 1.
DR CDD; cd15657; PHD4_NSD2; 1.
DR CDD; cd20162; PWWP_NSD2_rpt1; 1.
DR CDD; cd20165; PWWP_NSD2_rpt2; 1.
DR Gene3D; 2.30.30.140; -; 2.
DR Gene3D; 1.10.30.10; High mobility group box domain; 1.
DR Gene3D; 2.170.270.10; SET domain; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 3.
DR InterPro; IPR006560; AWS_dom.
DR InterPro; IPR047443; HMG-box_NSD2.
DR InterPro; IPR009071; HMG_box_dom.
DR InterPro; IPR036910; HMG_box_dom_sf.
DR InterPro; IPR047439; PHD2_NSD2.
DR InterPro; IPR047441; PHD3_NSD2.
DR InterPro; IPR000313; PWWP_dom.
DR InterPro; IPR047434; PWWP_NSD2_rpt1.
DR InterPro; IPR047435; PWWP_NSD2_rpt2.
DR InterPro; IPR001214; SET_dom.
DR InterPro; IPR046341; SET_dom_sf.
DR InterPro; IPR019786; Zinc_finger_PHD-type_CS.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR001965; Znf_PHD.
DR InterPro; IPR019787; Znf_PHD-finger.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR22884:SF293; HISTONE-LYSINE N-METHYLTRANSFERASE NSD2; 1.
DR PANTHER; PTHR22884; SET DOMAIN PROTEINS; 1.
DR Pfam; PF17907; AWS; 1.
DR Pfam; PF00505; HMG_box; 1.
DR Pfam; PF00628; PHD; 2.
DR Pfam; PF00855; PWWP; 2.
DR Pfam; PF00856; SET; 1.
DR SMART; SM00570; AWS; 1.
DR SMART; SM00398; HMG; 1.
DR SMART; SM00249; PHD; 3.
DR SMART; SM00293; PWWP; 2.
DR SMART; SM00184; RING; 2.
DR SMART; SM00317; SET; 1.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 2.
DR SUPFAM; SSF47095; HMG-box; 1.
DR SUPFAM; SSF82199; SET domain; 1.
DR SUPFAM; SSF63748; Tudor/PWWP/MBT; 2.
DR PROSITE; PS51215; AWS; 1.
DR PROSITE; PS50118; HMG_BOX_2; 1.
DR PROSITE; PS50812; PWWP; 2.
DR PROSITE; PS50280; SET; 1.
DR PROSITE; PS01359; ZF_PHD_1; 1.
DR PROSITE; PS50016; ZF_PHD_2; 2.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 4: Predicted;
KW Chromatin regulator {ECO:0000256|ARBA:ARBA00022853};
KW DNA-binding {ECO:0000256|PROSITE-ProRule:PRU00267};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000313|EMBL:KFQ50641.1};
KW Nucleus {ECO:0000256|PROSITE-ProRule:PRU00267};
KW Reference proteome {ECO:0000313|Proteomes:UP000053840};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transferase {ECO:0000313|EMBL:KFQ50641.1};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT DOMAIN 223..288
FT /note="PWWP"
FT /evidence="ECO:0000259|PROSITE:PS50812"
FT DOMAIN 457..506
FT /note="HMG box"
FT /evidence="ECO:0000259|PROSITE:PS50118"
FT DOMAIN 671..717
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT DOMAIN 734..780
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT DOMAIN 848..892
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT DOMAIN 897..959
FT /note="PWWP"
FT /evidence="ECO:0000259|PROSITE:PS50812"
FT DOMAIN 1028..1078
FT /note="AWS"
FT /evidence="ECO:0000259|PROSITE:PS51215"
FT DOMAIN 1080..1190
FT /note="SET"
FT /evidence="ECO:0000259|PROSITE:PS50280"
FT DNA_BIND 457..506
FT /note="HMG box"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00267"
FT REGION 143..171
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 190..209
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 372..459
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 512..662
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 157..171
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 394..410
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 411..437
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 534..570
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 571..595
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 607..632
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 633..647
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 648..662
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1190
FT /evidence="ECO:0000313|EMBL:KFQ50641.1"
SQ SEQUENCE 1190 AA; 134126 MW; 531B0940EE9F773F CRC64;
MDFSIKRSSQ LLTRKINYIK MKQVPEILGN TNGKTQNCEV NRECSVYLGK AQLSATLQEG
VMQKYNGHEA LPFIPADKLK DLTSRVFNGE SGAQDAKLRF EPQEIKGVGT PPNTTPIKNG
SPEIKLKITK TYMNGKPLFE SSICGDNGAD VSQSEENEQK PANKERRSRK RSIKYDSLLE
QGLVEAALVS KTSSPTEKKA PAKRDPTQST VKEDKVHLLK YNIGDLVWSK VSGFPWWPCM
VSADPVLHAY TKLKGQKKSF RQYHVQFFGD APERAWIFEK SLVPFKEKDQ FEQLCHESAK
QALTKAEKIK MLKPVSGKLR PQWEMGVKQA SEAVGMTVEE RKAKYTFIYV RDRPHLNPRV
AKEVGVAVEP LEEVDESSYS NEETTQNLKS MKESGIPNKR RRRTSKLSTT DDMEESTQSG
TKDTTPQKSS EQAESKRGIG SPLSRKKTPA STPRSRKGDA VSQFLVFCQK HRDEVVAEHP
DASSEEIEEL LESQWNMLSE KQKARYNTKF AIVTSPKSEE DSGNLHGNKR KQKKRTKEPT
EDFEVQEAPR KRLRMDKQNN RKRETSNDKT AKTNSSKVTE TSSSQKNQSA TKNLSDACKP
LKKRNRASAA ESSTLAFSKS SSPSASLTEN EISDGQGDER SESPYESADE TQTEVSISSK
KSERGAGTKK EYVCQLCEKT GDLLLCEGLC YRAFHVSCLG LSGRPAGKFI CSECTSGKSV
TLFSLLLPLG VHTCFVCKER KADVKRCVVS HCGKFYHEAC VKKFHLTVFE NRGFRCPLHS
CLSCHVSNPS HPRISKGKMM RCVRCPVAYH AGDVCIAAGC AVIASNSIVC TNHFTAMKGK
SHHAHVNVSW CFVCSKGGSL LCCESCPAAF HPDCLNIEMP DGSWYCNDCR AGKKLHFQDI
IWVKLGNYRW WPAEVCHPKN VPPNIQKMKH EIGEFPVFFF GSKDYYWTHQ ARVFPYMEGD
RGSRYQGIKG IGKVFKNALQ EAETRFREIK LQREAKETQE SERKPPPYKH IKVNKPCGKV
HIYTADISEI PKCNCKPTDE NPCGFDSECL NRMLMYECHP QVCPAGERCQ NQCFTKRQYP
ETKIIKTDGK GWGLVAKRDI KKGEFVNEYV GELIDEEECM ARIKYAHEND ITHFYMLTID
KDRIIDAGPK GNYSRFMNHS CQPNCETLKW TVNGDTRVGL FAVCDIPAGT
//
