ID A0A091S4Y1_NESNO Unreviewed; 1312 AA.
AC A0A091S4Y1;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE SubName: Full=DNA repair protein RAD50 {ECO:0000313|EMBL:KFQ51090.1};
GN ORFNames=N333_07907 {ECO:0000313|EMBL:KFQ51090.1};
OS Nestor notabilis (Kea).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Psittaciformes; Psittacidae; Nestor.
OX NCBI_TaxID=176057 {ECO:0000313|EMBL:KFQ51090.1, ECO:0000313|Proteomes:UP000053840};
RN [1] {ECO:0000313|EMBL:KFQ51090.1, ECO:0000313|Proteomes:UP000053840}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N333 {ECO:0000313|EMBL:KFQ51090.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947};
CC -!- SUBCELLULAR LOCATION: Chromosome, telomere
CC {ECO:0000256|ARBA:ARBA00004574}.
CC -!- SIMILARITY: Belongs to the SMC family. RAD50 subfamily.
CC {ECO:0000256|ARBA:ARBA00009439}.
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DR EMBL; KK941571; KFQ51090.1; -; Genomic_DNA.
DR RefSeq; XP_010014487.1; XM_010016185.1.
DR GeneID; 104407024; -.
DR KEGG; nnt:104407024; -.
DR CTD; 10111; -.
DR OrthoDB; 5477220at2759; -.
DR Proteomes; UP000053840; Unassembled WGS sequence.
DR GO; GO:0000781; C:chromosome, telomeric region; IEA:UniProtKB-SubCell.
DR GO; GO:0030870; C:Mre11 complex; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006302; P:double-strand break repair; IEA:InterPro.
DR GO; GO:0051321; P:meiotic cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0000723; P:telomere maintenance; IEA:InterPro.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR038729; Rad50/SbcC_AAA.
DR InterPro; IPR004584; Rad50_eukaryotes.
DR InterPro; IPR013134; Zn_hook_RAD50.
DR NCBIfam; TIGR00606; rad50; 1.
DR PANTHER; PTHR18867:SF12; DNA REPAIR PROTEIN RAD50; 1.
DR PANTHER; PTHR18867; RAD50; 1.
DR Pfam; PF13476; AAA_23; 1.
DR Pfam; PF04423; Rad50_zn_hook; 1.
DR Pfam; PF13558; SbcC_Walker_B; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF75712; Rad50 coiled-coil Zn hook; 1.
DR PROSITE; PS51131; ZN_HOOK; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Chromosome {ECO:0000256|ARBA:ARBA00022895};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Meiosis {ECO:0000256|ARBA:ARBA00023254};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723, ECO:0000256|PROSITE-
KW ProRule:PRU00471}; Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000053840};
KW Telomere {ECO:0000256|ARBA:ARBA00022895};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|PROSITE-ProRule:PRU00471}.
FT DOMAIN 635..734
FT /note="Zinc-hook"
FT /evidence="ECO:0000259|PROSITE:PS51131"
FT COILED 203..349
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 467..600
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 635..662
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 712..815
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 846..1070
FT /evidence="ECO:0000256|SAM:Coils"
FT BINDING 681
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00471"
FT BINDING 684
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00471"
SQ SEQUENCE 1312 AA; 153302 MW; 299BA7B6B401555B CRC64;
MSRIEKMSIL GVRSFGVEDK DKQIISFFNP LTILVGPNGA GKTTIIECLK YISTGDFPPG
TKGNSFVHDP KVANETDVRA QIRLQFRDVN GELVAVQRSM VCTQKGKKTE FKTLESVITR
TKHGEKFSLS SKCAEIDREM VSALGVSKSV INNVIFCHQE ESNWPLSEGK ALKQKFDEIF
SATRYIKALE TLRQVRLKQS LKVKECQTEL KYLKQNKEKA QEIQDHLSNR EAQLAASKEN
VKSIENQLDP LKSSLATVEQ NLTKVMRIDN DVKALESRRR QMEKDNQDLQ QKMEKVFQGT
DEQLKDRYQS HQRTVKEKEK RLLDCKRELD RATKECQRFN SEKSELLIEQ GRLQLEAGRH
QEHITMRDSL IQSLAAQLEL DGFEQTPFNE WHITSFHTLL KERQRKDTEA AQHLMREFTR
KEAMKQKQID DIRDKKTGLE KTIDLKSDIQ NKKQIELKNA KYELQQLEGF SDRIVELEEE
IVKTEKELEK TERSSSVEKL EREVQTLQNE KINLDKALRK LDQEMEQLNL HTTTITQMEM
LKKDKADKEE QIRKVKARHS DELTSLLGYF PNKNQLEDWL HSKNKNINQT RDNLAGLNKR
LVSVEYHKTY VSNELRNKEE QLSLHEEKLS NVCGSQDFDS DLNKLQDEIE KSSKQRAVLA
GATAVYSQFI TQLTEENQRC CPVCQRAFQT EADLQDVISD LQSKLRLAPD KLKSTESELK
RKEKKRDEMM SLKPLRQTVV ELQARDIPDL RNKIQNANRD LTGLKGEIEE QELLLQTALS
EEESAKACLQ DITLMERYQT DIRDVERKIA QQEAKLLGVD LSRTVLQVSQ EKQEKKHLWD
TVTSKIELNQ KLKQDQQNQV QQLKSTVNEL KAEKLQIFSS MQRRHQLEEQ TGELISEVQD
LCREIKEAKE QVFPLDATLE KLQQEKEDLV NKRTTSNKEA QDKMNGINEK VKDINKYMKE
IENYIQQGRD DYRKQKESEL SEVNSQLADC EKQKEKISKE METIRQDIDT QKVQERWLED
NLTLRKRKEE LKDVEDNIKR LVREMGEMKV PEMKNEQKHL EEKIESLKRN HHLALGRQRG
FEEEIVRFKK ELREPQFKDA EEKYRDMMIV MRTTELVNKD LDLYYKALDK AIMTFHSMKM
EEINKIIREL WRSTYRGQDI EYIEIRSDAD ENVSASDKRR SYNYRVVMVK GDTALDMRGR
CSAGQKVLAS LIIRLALAET FCLNCGILAL DEPTTNLDRE NIESLAHALV EIIKSRSQQR
NFQLLVITHD EDFVELLVRS EYVETFYRIR KNIDQCSEIM KCSASSLGSY VH
//
