ID A0A091S9K5_NESNO Unreviewed; 1026 AA.
AC A0A091S9K5;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE SubName: Full=Atrial natriuretic peptide-converting enzyme {ECO:0000313|EMBL:KFQ53988.1};
DE Flags: Fragment;
GN ORFNames=N333_01618 {ECO:0000313|EMBL:KFQ53988.1};
OS Nestor notabilis (Kea).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Psittaciformes; Psittacidae; Nestor.
OX NCBI_TaxID=176057 {ECO:0000313|EMBL:KFQ53988.1, ECO:0000313|Proteomes:UP000053840};
RN [1] {ECO:0000313|EMBL:KFQ53988.1, ECO:0000313|Proteomes:UP000053840}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N333 {ECO:0000313|EMBL:KFQ53988.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004401};
CC Single-pass type II membrane protein {ECO:0000256|ARBA:ARBA00004401}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00124}.
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DR EMBL; KK945494; KFQ53988.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A091S9K5; -.
DR Proteomes; UP000053840; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0016486; P:peptide hormone processing; IEA:InterPro.
DR GO; GO:0008217; P:regulation of blood pressure; IEA:InterPro.
DR CDD; cd07445; CRD_corin_1; 1.
DR CDD; cd00112; LDLa; 6.
DR CDD; cd00190; Tryp_SPc; 1.
DR Gene3D; 1.10.2000.10; Frizzled cysteine-rich domain; 2.
DR Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 7.
DR Gene3D; 2.40.10.10; Trypsin-like serine proteases; 1.
DR InterPro; IPR017052; Corin.
DR InterPro; IPR041762; Corin_CRD_1.
DR InterPro; IPR020067; Frizzled_dom.
DR InterPro; IPR036790; Frizzled_dom_sf.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR023415; LDLR_class-A_CS.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR InterPro; IPR009003; Peptidase_S1_PA.
DR InterPro; IPR043504; Peptidase_S1_PA_chymotrypsin.
DR InterPro; IPR017448; SRCR-like_dom.
DR InterPro; IPR036772; SRCR-like_dom_sf.
DR InterPro; IPR001254; Trypsin_dom.
DR InterPro; IPR033116; TRYPSIN_SER.
DR PANTHER; PTHR24252; ACROSIN-RELATED; 1.
DR PANTHER; PTHR24252:SF9; ATRIAL NATRIURETIC PEPTIDE-CONVERTING ENZYME ISOFORM X1; 1.
DR Pfam; PF01392; Fz; 2.
DR Pfam; PF00057; Ldl_recept_a; 7.
DR Pfam; PF15494; SRCR_2; 1.
DR Pfam; PF00089; Trypsin; 1.
DR PIRSF; PIRSF036376; Corin; 1.
DR PRINTS; PR00261; LDLRECEPTOR.
DR SMART; SM00063; FRI; 2.
DR SMART; SM00192; LDLa; 7.
DR SMART; SM00020; Tryp_SPc; 1.
DR SUPFAM; SSF63501; Frizzled cysteine-rich domain; 2.
DR SUPFAM; SSF57424; LDL receptor-like module; 7.
DR SUPFAM; SSF56487; SRCR-like; 1.
DR SUPFAM; SSF50494; Trypsin-like serine proteases; 1.
DR PROSITE; PS50038; FZ; 2.
DR PROSITE; PS01209; LDLRA_1; 2.
DR PROSITE; PS50068; LDLRA_2; 7.
DR PROSITE; PS50240; TRYPSIN_DOM; 1.
DR PROSITE; PS00135; TRYPSIN_SER; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00124}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000053840};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 25..51
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 118..244
FT /note="FZ"
FT /evidence="ECO:0000259|PROSITE:PS50038"
FT DOMAIN 432..555
FT /note="FZ"
FT /evidence="ECO:0000259|PROSITE:PS50038"
FT DOMAIN 786..1019
FT /note="Peptidase S1"
FT /evidence="ECO:0000259|PROSITE:PS50240"
FT ACT_SITE 827
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR036376-50"
FT ACT_SITE 876
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR036376-50"
FT ACT_SITE 969
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR036376-50"
FT DISULFID 123..184
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00090"
FT DISULFID 131..177
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00090"
FT DISULFID 201..225
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00090"
FT DISULFID 262..280
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 274..289
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 291..303
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 298..316
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 310..325
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 335..353
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 347..362
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 372..390
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 384..399
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 484..522
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00090"
FT DISULFID 511..552
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00090"
FT DISULFID 515..539
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00090"
FT DISULFID 562..574
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 569..587
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 581..596
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 619..634
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 637..649
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 644..662
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 656..671
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFQ53988.1"
FT NON_TER 1026
FT /evidence="ECO:0000313|EMBL:KFQ53988.1"
SQ SEQUENCE 1026 AA; 114678 MW; 771E3FD6CD6AD680 CRC64;
VLGADEDNMG DGCSQKLASA KFLRLLLLIL IPCICALILL LVILVTFVGV LEKTCFYSNG
SEVLTVNGDI ETSGDLLPNM AENSSKTDPT MDLSTQPSSW TTMPLSHVDQ MNKNSNIFRE
SACINITNSQ CQMLPYNYTT TTSVLSIVKS IEMEKFLKFF SYLSRLGCYQ HIMLFGCSLA
LPECISDGDD SQGLLPCRTF CEEAKEGCEP VLGMVNASWP EFLKCSQFQH KTENDTTTRV
CFSPLQEKGK QSLCGGEESF LCASGICIPG KLQCNGYNDC DDWSDEVHCN CSDDVFRCDT
GKCLNYTFLC DGYDDCGDLS DEQNCDCNPV THHQCGDGRC ITADWVCDGD HDCIDKSDEI
NCSCHSQGLV ECRNGQCIPS AFQCDGDNDC KDGSDEENCS ESQTLCQEGD QRCTFCPDPC
GTSLCEMRNS QTNCSQCEPI TLELCMNLPY NYTYYPNYLG HRTQKEASIS WESSLFPALV
QTNCYKYLMF FACTILVPKC DPYTNQRIPP CRTLCVQSKE RCESVLGIVG LQWPEDTDCT
QFPDENSDNK TCLTPDEGVE ECSPSHFKCR SGRCVLASRR CDGQADCEDD SDEDSCGCIE
RGLWECPLKK LCIKHSMICD GFPDCPDMVD EKNCSFCEES ELECANHECV PRELWCDGQA
DCSDSSDEWD CVTLSKNMNS LMFLTIHRSA AANHVCADEW QENLSQLACN QMGLGGLSKT
EIVIEKEEMQ HQKWLNLHSD WKNKNASTLH ALLVNGQVCR SRSKVALFCT KADCGRRPAA
RMSKRILGGR TSRPGRWPWQ CSLQSEPSGH ICGCVLIAKR WVLTVAHCFE GRENAAVWKV
VFGISNLDHP SVFMQTRLVK AIILHPRYNR AVVDYDISIV ELDEDINETS YVRPVCLPSK
DQLVQPDTYC YITGWGHMGN KMPFKLQEGE VRIISLEQCQ SYFDMKTITS RMLCAGYESG
TVDSCMGDSG GPLVCEQPAG RWTLFGLTSW GSVCFSKVLG PGVYSNVSHF IEWIERQIYI
HTFLLN
//
