ID A0A091SB28_NESNO Unreviewed; 826 AA.
AC A0A091SB28;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 24-JAN-2024, entry version 46.
DE SubName: Full=Disintegrin and metalloproteinase domain-containing protein 9 {ECO:0000313|EMBL:KFQ55768.1};
DE Flags: Fragment;
GN ORFNames=N333_11013 {ECO:0000313|EMBL:KFQ55768.1};
OS Nestor notabilis (Kea).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Psittaciformes; Psittacidae; Nestor.
OX NCBI_TaxID=176057 {ECO:0000313|EMBL:KFQ55768.1, ECO:0000313|Proteomes:UP000053840};
RN [1] {ECO:0000313|EMBL:KFQ55768.1, ECO:0000313|Proteomes:UP000053840}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N333 {ECO:0000313|EMBL:KFQ55768.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR EMBL; KK947738; KFQ55768.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A091SB28; -.
DR MEROPS; M12.209; -.
DR Proteomes; UP000053840; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR CDD; cd04269; ZnMc_adamalysin_II_like; 1.
DR Gene3D; 3.40.390.10; Collagenase (Catalytic Domain); 1.
DR Gene3D; 4.10.70.10; Disintegrin domain; 1.
DR InterPro; IPR006586; ADAM_Cys-rich.
DR InterPro; IPR018358; Disintegrin_CS.
DR InterPro; IPR001762; Disintegrin_dom.
DR InterPro; IPR036436; Disintegrin_dom_sf.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR013111; EGF_extracell.
DR InterPro; IPR024079; MetalloPept_cat_dom_sf.
DR InterPro; IPR001590; Peptidase_M12B.
DR InterPro; IPR002870; Peptidase_M12B_N.
DR InterPro; IPR034027; Reprolysin_adamalysin.
DR PANTHER; PTHR11905; ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN; 1.
DR PANTHER; PTHR11905:SF136; DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 9; 1.
DR Pfam; PF08516; ADAM_CR; 1.
DR Pfam; PF00200; Disintegrin; 1.
DR Pfam; PF07974; EGF_2; 1.
DR Pfam; PF01562; Pep_M12B_propep; 1.
DR Pfam; PF01421; Reprolysin; 1.
DR SMART; SM00608; ACR; 1.
DR SMART; SM00050; DISIN; 1.
DR SUPFAM; SSF57552; Blood coagulation inhibitor (disintegrin); 1.
DR SUPFAM; SSF55486; Metalloproteases ('zincins'), catalytic domain; 1.
DR PROSITE; PS50215; ADAM_MEPRO; 1.
DR PROSITE; PS00427; DISINTEGRIN_1; 1.
DR PROSITE; PS50214; DISINTEGRIN_2; 1.
DR PROSITE; PS01186; EGF_2; 1.
DR PROSITE; PS50026; EGF_3; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Integrin {ECO:0000313|EMBL:KFQ55768.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00276};
KW Reference proteome {ECO:0000313|Proteomes:UP000053840};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Zinc {ECO:0000256|PROSITE-ProRule:PRU00276}.
FT TRANSMEM 662..681
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 178..372
FT /note="Peptidase M12B"
FT /evidence="ECO:0000259|PROSITE:PS50215"
FT DOMAIN 380..467
FT /note="Disintegrin"
FT /evidence="ECO:0000259|PROSITE:PS50214"
FT DOMAIN 606..640
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REGION 713..762
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 778..826
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 781..807
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 314
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00276"
FT BINDING 313
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00276"
FT BINDING 317
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00276"
FT BINDING 323
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00276"
FT DISULFID 331..336
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00276"
FT DISULFID 439..459
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00068"
FT DISULFID 630..639
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFQ55768.1"
FT NON_TER 826
FT /evidence="ECO:0000313|EMBL:KFQ55768.1"
SQ SEQUENCE 826 AA; 91891 MW; 12018DAF06CCD231 CRC64;
QQVSLLSSYE VVIPQRLGRE RREAFNVSSV QDKVSYAIEI EGKEYTIHLE KNKELLPKDF
TVYTYNKEGK LQSEYPDVQD HCHYQGYVEG SLDSVVALST CSGLRGLVTI GNITYGIEPM
DSSSGSKHIL YRLDNVRKEP TMCGVTAEDH GREHTEENHH PTMTQLLRMK RAVLHQTRYV
ELFIVVDKEK FEDFGKSETE VREHMVQLAN FLDSMYIMLN IRIVLVGLEI WKYENIISTD
GGAGDVLANF VQWREKNLVL RRRHDSAQFV LKKGFGGTAG MAYVGTVCSK SHAGGINVFG
RISIQMFASI MAHELGHNLG MNHDDERVCH CGASSCIMSS GASGSRNFSS CSAEDFEKLT
LNKGGSCLLN VPKPDETYSV PYCGNKLVDA GEECDCGSPK ECESDPCCEP GTCRLRSSAA
CAYGDCCKNC QLLPGGTECR ASSNECDLPE YCNGTSQFCQ PDFTVQNGHP CHNEEAYCYN
GVCQYYDAQC QDIFGSKAKA APNICFAEVN SKGDRFGNCG FHGHDYKKCS SWNAMCGKLQ
CENVKTMPVF GIKPAIIQTP IRGTMCWGVD FQLGSDVPDP GMVNEGTKCD TGKICRHFQC
VSASVLNYDC DVEKQCHGHG VCNNNRNCHC EPGWAPPYCD VKGYGGSVDS GPPYNGKSRN
GLLVFFFLVL PLLVAAALAF VKRDRLKRCY RRAMSRCHSV TCSLHWLGFR SRPSAPPRTE
AEPRDHHHHH HQGFSHGMPY APRGAPMDME PNTFPVPSYP VNQHPQQAYH QSYYPPLQYQ
APQPQKLPTR PPPPQQQRAP QGPPPSQHKC LPQGQYFPSR PAPLPP
//
